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ZC3HAV1 (zinc finger CCCH-type, antiviral 1)

Identity

Alias_symbol (synonym)ZAP
FLB6421
FLJ13288
MGC48898
ZC3HDC2
ZC3H2
PARP13
Other aliasARTD13
HGNC (Hugo) ZC3HAV1
LocusID (NCBI) 56829
Atlas_Id 75888
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 138728266 and ends at 138794465 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABL2 (1q25.2) / ZC3HAV1 (7q34)ITPKB (1q42.12) / ZC3HAV1 (7q34)MGEA5 (10q24.32) / ZC3HAV1 (7q34)
TNPO3 (7q32.1) / ZC3HAV1 (7q34)ZC3HAV1 (7q34) / ABL2 (1q25.2)ZC3HAV1 (7q34) / BRAF (7q34)
ZC3HAV1 (7q34) / CTSS (1q21.3)ZC3HAV1 (7q34) / ITPKB (1q42.12)ZC3HAV1 ITPKB
ZC3HAV1 BRAF

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZC3HAV1   23721
Cards
Entrez_Gene (NCBI)ZC3HAV1  56829  zinc finger CCCH-type, antiviral 1
AliasesARTD13; FLB6421; PARP13; ZAP; 
ZC3H2; ZC3HDC2
GeneCards (Weizmann)ZC3HAV1
Ensembl hg19 (Hinxton)ENSG00000105939 [Gene_View]  chr7:138728266-138794465 [Contig_View]  ZC3HAV1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000105939 [Gene_View]  chr7:138728266-138794465 [Contig_View]  ZC3HAV1 [Vega]
ICGC DataPortalENSG00000105939
TCGA cBioPortalZC3HAV1
AceView (NCBI)ZC3HAV1
Genatlas (Paris)ZC3HAV1
WikiGenes56829
SOURCE (Princeton)ZC3HAV1
Genetics Home Reference (NIH)ZC3HAV1
Genomic and cartography
GoldenPath hg19 (UCSC)ZC3HAV1  -     chr7:138728266-138794465 -  7q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZC3HAV1  -     7q34   [Description]    (hg38-Dec_2013)
EnsemblZC3HAV1 - 7q34 [CytoView hg19]  ZC3HAV1 - 7q34 [CytoView hg38]
Mapping of homologs : NCBIZC3HAV1 [Mapview hg19]  ZC3HAV1 [Mapview hg38]
OMIM607312   
Gene and transcription
Genbank (Entrez)AF138863 AK023350 AK055851 AK098308 AK292811
RefSeq transcript (Entrez)NM_020119 NM_024625
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029457 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ZC3HAV1
Cluster EST : UnigeneHs.133512 [ NCBI ]
CGAP (NCI)Hs.133512
Alternative Splicing GalleryENSG00000105939
Gene ExpressionZC3HAV1 [ NCBI-GEO ]   ZC3HAV1 [ EBI - ARRAY_EXPRESS ]   ZC3HAV1 [ SEEK ]   ZC3HAV1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZC3HAV1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56829
GTEX Portal (Tissue expression)ZC3HAV1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2W4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2W4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2W4
Splice isoforms : SwissVarQ7Z2W4
PhosPhoSitePlusQ7Z2W4
Domaine pattern : Prosite (Expaxy)PARP_CATALYTIC (PS51059)    WWE (PS50918)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Poly(ADP-ribose)pol_cat_dom    WWE-dom    Znf_CCCH   
Domain families : Pfam (Sanger)PARP (PF00644)   
Domain families : Pfam (NCBI)pfam00644   
Conserved Domain (NCBI)ZC3HAV1
DMDM Disease mutations56829
Blocks (Seattle)ZC3HAV1
PDB (SRS)2X5Y    4X52   
PDB (PDBSum)2X5Y    4X52   
PDB (IMB)2X5Y    4X52   
PDB (RSDB)2X5Y    4X52   
Structural Biology KnowledgeBase2X5Y    4X52   
SCOP (Structural Classification of Proteins)2X5Y    4X52   
CATH (Classification of proteins structures)2X5Y    4X52   
SuperfamilyQ7Z2W4
Human Protein AtlasENSG00000105939
Peptide AtlasQ7Z2W4
HPRD09534
IPIIPI00410067   IPI00332936   IPI00410070   IPI00410071   IPI00981976   IPI00410069   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2W4
IntAct (EBI)Q7Z2W4
FunCoupENSG00000105939
BioGRIDZC3HAV1
STRING (EMBL)ZC3HAV1
ZODIACZC3HAV1
Ontologies - Pathways
QuickGOQ7Z2W4
Ontology : AmiGONAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytoplasm  Golgi apparatus  metabolic process  response to virus  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of I-kappaB kinase/NF-kappaB signaling  poly(A) RNA binding  negative regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  positive regulation of mRNA catabolic process  positive regulation of RIG-I signaling pathway  
Ontology : EGO-EBINAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytoplasm  Golgi apparatus  metabolic process  response to virus  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of I-kappaB kinase/NF-kappaB signaling  poly(A) RNA binding  negative regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  positive regulation of mRNA catabolic process  positive regulation of RIG-I signaling pathway  
NDEx NetworkZC3HAV1
Atlas of Cancer Signalling NetworkZC3HAV1
Wikipedia pathwaysZC3HAV1
Orthology - Evolution
OrthoDB56829
GeneTree (enSembl)ENSG00000105939
Phylogenetic Trees/Animal Genes : TreeFamZC3HAV1
HOVERGENQ7Z2W4
HOGENOMQ7Z2W4
Homologs : HomoloGeneZC3HAV1
Homology/Alignments : Family Browser (UCSC)ZC3HAV1
Gene fusions - Rearrangements
Fusion: TCGAZC3HAV1 ITPKB
Fusion: TCGAZC3HAV1 BRAF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZC3HAV1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZC3HAV1
dbVarZC3HAV1
ClinVarZC3HAV1
1000_GenomesZC3HAV1 
Exome Variant ServerZC3HAV1
ExAC (Exome Aggregation Consortium)ZC3HAV1 (select the gene name)
Genetic variants : HAPMAP56829
Genomic Variants (DGV)ZC3HAV1 [DGVbeta]
DECIPHER (Syndromes)7:138728266-138794465  ENSG00000105939
CONAN: Copy Number AnalysisZC3HAV1 
Mutations
ICGC Data PortalZC3HAV1 
TCGA Data PortalZC3HAV1 
Broad Tumor PortalZC3HAV1
OASIS PortalZC3HAV1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZC3HAV1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZC3HAV1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZC3HAV1
DgiDB (Drug Gene Interaction Database)ZC3HAV1
DoCM (Curated mutations)ZC3HAV1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZC3HAV1 (select a term)
intoGenZC3HAV1
Cancer3DZC3HAV1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607312   
Orphanet
MedgenZC3HAV1
Genetic Testing Registry ZC3HAV1
NextProtQ7Z2W4 [Medical]
TSGene56829
GENETestsZC3HAV1
Huge Navigator ZC3HAV1 [HugePedia]
snp3D : Map Gene to Disease56829
BioCentury BCIQZC3HAV1
ClinGenZC3HAV1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56829
Chemical/Pharm GKB GenePA134944289
Clinical trialZC3HAV1
Miscellaneous
canSAR (ICR)ZC3HAV1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZC3HAV1
EVEXZC3HAV1
GoPubMedZC3HAV1
iHOPZC3HAV1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:52:11 CET 2017

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