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ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)

Identity

Alias (NCBI)ARTD13
FLB6421
PARP13
ZAP
ZC3H2
ZC3HDC2
HGNC (Hugo) ZC3HAV1
HGNC Alias symbZAP
FLB6421
FLJ13288
MGC48898
ZC3HDC2
ZC3H2
PARP13
ARTD13
HGNC Alias namezinc finger antiviral protein
  CCCH-type zinc finger antiviral protein
LocusID (NCBI) 56829
Atlas_Id 57769
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 139060340 and ends at 139109720 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABL2 (1q25.2) / ZC3HAV1 (7q34)ITPKB (1q42.12) / ZC3HAV1 (7q34)MGEA5 (10q24.32) / ZC3HAV1 (7q34)
TNPO3 (7q32.1) / ZC3HAV1 (7q34)ZC3HAV1 (7q34) / ABL2 (1q25.2)ZC3HAV1 (7q34) / BRAF (7q34)
ZC3HAV1 (7q34) / CTSS (1q21.3)ZC3HAV1 (7q34) / ITPKB (1q42.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;7)(q25;q34) ZC3HAV1/ABL2
t(7;13)(q34;q14) ZC3HAV1/AKAP11


External links

Nomenclature
HGNC (Hugo)ZC3HAV1   23721
Cards
Entrez_Gene (NCBI)ZC3HAV1    zinc finger CCCH-type containing, antiviral 1
AliasesARTD13; FLB6421; PARP13; ZAP; 
ZC3H2; ZC3HDC2
GeneCards (Weizmann)ZC3HAV1
Ensembl hg19 (Hinxton)ENSG00000105939 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105939 [Gene_View]  ENSG00000105939 [Sequence]  chr7:139060340-139109720 [Contig_View]  ZC3HAV1 [Vega]
ICGC DataPortalENSG00000105939
TCGA cBioPortalZC3HAV1
AceView (NCBI)ZC3HAV1
Genatlas (Paris)ZC3HAV1
SOURCE (Princeton)ZC3HAV1
Genetics Home Reference (NIH)ZC3HAV1
Genomic and cartography
GoldenPath hg38 (UCSC)ZC3HAV1  -     chr7:139060340-139109720 -  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZC3HAV1  -     7q34   [Description]    (hg19-Feb_2009)
GoldenPathZC3HAV1 - 7q34 [CytoView hg19]  ZC3HAV1 - 7q34 [CytoView hg38]
ImmunoBaseENSG00000105939
genome Data Viewer NCBIZC3HAV1 [Mapview hg19]  
OMIM607312   
Gene and transcription
Genbank (Entrez)AF138863 AI133088 AK023350 AK055851 AK098308
RefSeq transcript (Entrez)NM_001363491 NM_020119 NM_024625
Consensus coding sequences : CCDS (NCBI)ZC3HAV1
Alternative Splicing GalleryENSG00000105939
Gene ExpressionZC3HAV1 [ NCBI-GEO ]   ZC3HAV1 [ EBI - ARRAY_EXPRESS ]   ZC3HAV1 [ SEEK ]   ZC3HAV1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZC3HAV1 [ Firebrowse - Broad ]
GenevisibleExpression of ZC3HAV1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56829
GTEX Portal (Tissue expression)ZC3HAV1
Human Protein AtlasENSG00000105939-ZC3HAV1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2W4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2W4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2W4
PhosPhoSitePlusQ7Z2W4
Domaine pattern : Prosite (Expaxy)PARP_CATALYTIC (PS51059)    WWE (PS50918)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Poly(ADP-ribose)pol_cat_dom    WH-like_DNA-bd_sf    WWE-dom    WWE_dom_sf    ZAP_HTH    Znf-CCCH_8    Znf_CCCH   
Domain families : Pfam (Sanger)HTH_53 (PF18606)    PARP (PF00644)    WWE (PF02825)    zf-CCCH_8 (PF18633)   
Domain families : Pfam (NCBI)pfam18606    pfam00644    pfam02825    pfam18633   
Conserved Domain (NCBI)ZC3HAV1
PDB (RSDB)2X5Y    4X52    6UEI    6UEJ   
PDB Europe2X5Y    4X52    6UEI    6UEJ   
PDB (PDBSum)2X5Y    4X52    6UEI    6UEJ   
PDB (IMB)2X5Y    4X52    6UEI    6UEJ   
Structural Biology KnowledgeBase2X5Y    4X52    6UEI    6UEJ   
SCOP (Structural Classification of Proteins)2X5Y    4X52    6UEI    6UEJ   
CATH (Classification of proteins structures)2X5Y    4X52    6UEI    6UEJ   
SuperfamilyQ7Z2W4
AlphaFold pdb e-kbQ7Z2W4   
Human Protein Atlas [tissue]ENSG00000105939-ZC3HAV1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2W4
IntAct (EBI)Q7Z2W4
BioGRIDZC3HAV1
STRING (EMBL)ZC3HAV1
ZODIACZC3HAV1
Ontologies - Pathways
QuickGOQ7Z2W4
Ontology : AmiGORNA binding  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytosol  protein ADP-ribosylation  response to virus  negative regulation of viral genome replication  innate immune response  cadherin binding  metal ion binding  defense response to virus  positive regulation of mRNA catabolic process  protein poly-ADP-ribosylation  NAD+ binding  protein ADP-ribosylase activity  
Ontology : EGO-EBIRNA binding  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytosol  protein ADP-ribosylation  response to virus  negative regulation of viral genome replication  innate immune response  cadherin binding  metal ion binding  defense response to virus  positive regulation of mRNA catabolic process  protein poly-ADP-ribosylation  NAD+ binding  protein ADP-ribosylase activity  
NDEx NetworkZC3HAV1
Atlas of Cancer Signalling NetworkZC3HAV1
Wikipedia pathwaysZC3HAV1
Orthology - Evolution
OrthoDB56829
GeneTree (enSembl)ENSG00000105939
Phylogenetic Trees/Animal Genes : TreeFamZC3HAV1
Homologs : HomoloGeneZC3HAV1
Homology/Alignments : Family Browser (UCSC)ZC3HAV1
Gene fusions - Rearrangements
Fusion : QuiverZC3HAV1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZC3HAV1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZC3HAV1
dbVarZC3HAV1
ClinVarZC3HAV1
MonarchZC3HAV1
1000_GenomesZC3HAV1 
Exome Variant ServerZC3HAV1
GNOMAD BrowserENSG00000105939
Varsome BrowserZC3HAV1
Genomic Variants (DGV)ZC3HAV1 [DGVbeta]
DECIPHERZC3HAV1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZC3HAV1 
Mutations
ICGC Data PortalZC3HAV1 
TCGA Data PortalZC3HAV1 
Broad Tumor PortalZC3HAV1
OASIS PortalZC3HAV1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZC3HAV1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZC3HAV1
Mutations and Diseases : HGMDZC3HAV1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch ZC3HAV1
DgiDB (Drug Gene Interaction Database)ZC3HAV1
DoCM (Curated mutations)ZC3HAV1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZC3HAV1 (select a term)
Cancer3DZC3HAV1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607312   
Orphanet
DisGeNETZC3HAV1
MedgenZC3HAV1
Genetic Testing Registry ZC3HAV1
NextProtQ7Z2W4 [Medical]
GENETestsZC3HAV1
Target ValidationZC3HAV1
Huge Navigator ZC3HAV1 [HugePedia]
ClinGenZC3HAV1
Clinical trials, drugs, therapy
MyCancerGenomeZC3HAV1
Protein Interactions : CTDZC3HAV1
Pharm GKB GenePA134944289
PharosQ7Z2W4
Clinical trialZC3HAV1
Miscellaneous
canSAR (ICR)ZC3HAV1
HarmonizomeZC3HAV1
DataMed IndexZC3HAV1
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZC3HAV1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:44:30 CEST 2021

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