ZC3HC1 (zinc finger C3HC-type containing 1)

2003-10-01  

Identity

HGNC
ZC3HC1
LOCATION
7q32.2
LOCUSID
51530
ALIAS
HSPC216,NIPA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51530
HGNC: 29913
Ensembl: ENSG00000091732

Variants:

dbSNP: 51530
ClinVar: 51530
TCGA: ENSG00000091732
COSMIC: ZC3HC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091732ENST00000311873Q86WB0
ENSG00000091732ENST00000358303Q86WB0
ENSG00000091732ENST00000360708Q86WB0
ENSG00000091732ENST00000467642F8WF13
ENSG00000091732ENST00000470651F8WDK5
ENSG00000091732ENST00000481503C9J0I9
ENSG00000091732ENST00000483827F8WBD7
ENSG00000091732ENST00000484432F8WAU5
ENSG00000091732ENST00000648450F8WAU5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
160091322005NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.32
127481722003Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).18
242862972013The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis.11
222059872011APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.8
229552832012Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.7
272266292016The Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle Regulation.4
281154892017Functional Validation of a Common Nonsynonymous Coding Variant in ZC3HC1 Associated With Protection From Coronary Artery Disease.2
262663512015Association of Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) rs11556924 Genetic Variant With Hypertension in a Finnish Population, the TAMRISK Study.1
315070942019The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension risk.1

Citation

Dessen P

ZC3HC1 (zinc finger C3HC-type containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/482/zc3hc1