ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8)

2014-11-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
DHHC8,ZDHHCL1,ZNF378
FUSION GENES

Other Information

Locus ID:

NCBI: 29801
MIM: 608784
HGNC: 18474
Ensembl: ENSG00000099904

Variants:

dbSNP: 29801
ClinVar: 29801
TCGA: ENSG00000099904
COSMIC: ZDHHC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099904ENST00000320602Q9ULC8
ENSG00000099904ENST00000334554Q9ULC8
ENSG00000099904ENST00000405930Q9ULC8
ENSG00000099904ENST00000436518C9JVM2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
198013772010Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.127
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
204680642010Association study of 182 candidate genes in anorexia nervosa.30
154892192004Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.21
154892192004Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.21
206619372010Testing for genetic association between the ZDHHC8 gene locus and susceptibility to schizophrenia: An integrated analysis of multiple datasets.13
206619372010Testing for genetic association between the ZDHHC8 gene locus and susceptibility to schizophrenia: An integrated analysis of multiple datasets.13
162256752005ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies.11
168605412006Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility.11

Citation

Dessen P

ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75918/zdhhc8