| ACBD5 (10p12.1) / ZEB1 (10p11.22) | ECT2L (6q24.1) / ZEB1 (10p11.22) | EPC1 (10p11.22) / ZEB1 (10p11.22) |
|
MIR548N (2q31.2) / ZEB1 (10p11.22) | RAB31 (18p11.22) / ZEB1 (10p11.22) | ZEB1 (10p11.22) / BMI1 (10p12.2) |
|
ZEB1 (10p11.22) / SIK1 (21q22.3) | ZEB1 (10p11.22) / WAC (10p12.1) | ZEB1 (10p11.22) / ZEB1 (10p11.22) |
|
ZEB1 (10p11.22) / ZNF438 (10p11.23) |
| Nomenclature |
HGNC (Hugo) | ZEB1 11642 |
| Cards |
Entrez_Gene (NCBI) | ZEB1 zinc finger E-box binding homeobox 1 |
Aliases | AREB6; BZP; DELTAEF1; FECD6; |
| NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A |
GeneCards (Weizmann) | ZEB1 |
Ensembl hg19 (Hinxton) | ENSG00000148516 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000148516 [Gene_View]  ENSG00000148516 [Sequence] chr10:31319216-31529804 [Contig_View] ZEB1 [Vega] |
ICGC DataPortal | ENSG00000148516 |
TCGA cBioPortal | ZEB1 |
AceView (NCBI) | ZEB1 |
Genatlas (Paris) | ZEB1 |
SOURCE (Princeton) | ZEB1 |
Genetics Home Reference (NIH) | ZEB1 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | ZEB1 - chr10:31319216-31529804 + 10p11.22 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | ZEB1 - 10p11.22 [Description] (hg19-Feb_2009) |
GoldenPath | ZEB1 - 10p11.22 [CytoView hg19] ZEB1 - 10p11.22 [CytoView hg38] |
ImmunoBase | ENSG00000148516 |
genome Data Viewer NCBI | ZEB1 [Mapview hg19] |
OMIM | 189909 609141 613270 |
| Gene and transcription |
Genbank (Entrez) | AI086650 AK091478 AK294775 AK296244 AK299541 |
RefSeq transcript (Entrez) | NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678 NM_030751 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | ZEB1 |
Alternative Splicing Gallery | ENSG00000148516 |
Gene Expression | ZEB1 [ NCBI-GEO ] ZEB1 [ EBI - ARRAY_EXPRESS ]
ZEB1 [ SEEK ] ZEB1 [ MEM ] |
Gene Expression Viewer (FireBrowse) | ZEB1 [ Firebrowse - Broad ] |
Genevisible | Expression of ZEB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6935 |
GTEX Portal (Tissue expression) | ZEB1 |
Human Protein Atlas | ENSG00000148516-ZEB1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P37275 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P37275 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P37275 |
Splice isoforms : SwissVar | P37275 |
PhosPhoSitePlus | P37275 |
Domaine pattern : Prosite (Expaxy) | ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157) |
Domains : Interpro (EBI) | Di19_Zn_binding_dom Homeobox-like_sf Homeobox_dom Znf_C2H2_sf Znf_C2H2_type |
Domain families : Pfam (Sanger) | zf-C2H2 (PF00096) zf-Di19 (PF05605) |
Domain families : Pfam (NCBI) | pfam00096 pfam05605 |
Domain families : Smart (EMBL) | HOX (SM00389) ZnF_C2H2 (SM00355) |
Conserved Domain (NCBI) | ZEB1 |
Blocks (Seattle) | ZEB1 |
PDB (RSDB) | 2.00E+19 |
PDB Europe | 2.00E+19 |
PDB (PDBSum) | 2.00E+19 |
PDB (IMB) | 2.00E+19 |
Structural Biology KnowledgeBase | 2.00E+19 |
SCOP (Structural Classification of Proteins) | 2.00E+19 |
CATH (Classification of proteins structures) | 2.00E+19 |
Superfamily | P37275 |
Human Protein Atlas [tissue] | ENSG00000148516-ZEB1 [tissue] |
Peptide Atlas | P37275 |
HPRD | 01798 |
IPI | IPI00375505 IPI00909527 IPI01015365 IPI01009961 IPI01014891 IPI01009478 IPI00942556 IPI00956719 IPI00956700 IPI00477152 IPI00514481 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P37275 |
IntAct (EBI) | P37275 |
BioGRID | ZEB1 |
STRING (EMBL) | ZEB1 |
ZODIAC | ZEB1 |
| Ontologies - Pathways |
QuickGO | P37275 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding DNA-binding transcription factor activity transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm cytosol regulation of transcription by RNA polymerase II pattern specification process central nervous system development zinc ion binding negative regulation of cell proliferation regulation of mesenchymal cell proliferation regulation of transforming growth factor beta receptor signaling pathway cytokine-mediated signaling pathway regulation of T cell differentiation in thymus negative regulation of endothelial cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic camera-type eye morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis regulation of smooth muscle cell differentiation cartilage development E-box binding cellular response to amino acid stimulus cochlea morphogenesis |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding DNA-binding transcription factor activity transcription coactivator activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm cytosol regulation of transcription by RNA polymerase II pattern specification process central nervous system development zinc ion binding negative regulation of cell proliferation regulation of mesenchymal cell proliferation regulation of transforming growth factor beta receptor signaling pathway cytokine-mediated signaling pathway regulation of T cell differentiation in thymus negative regulation of endothelial cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic camera-type eye morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis regulation of smooth muscle cell differentiation cartilage development E-box binding cellular response to amino acid stimulus cochlea morphogenesis |
Pathways : KEGG | Transcriptional misregulation in cancer MicroRNAs in cancer |
NDEx Network | ZEB1 |
Atlas of Cancer Signalling Network | ZEB1 |
Wikipedia pathways | ZEB1 |
| Orthology - Evolution |
OrthoDB | 6935 |
GeneTree (enSembl) | ENSG00000148516 |
Phylogenetic Trees/Animal Genes : TreeFam | ZEB1 |
HOGENOM | P37275 |
Homologs : HomoloGene | ZEB1 |
Homology/Alignments : Family Browser (UCSC) | ZEB1 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | ZEB1/BMI1 [10p11.22/10p12.2]   |
Fusion : Quiver | ZEB1 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | ZEB1 [hg38] |
dbVar | ZEB1 |
ClinVar | ZEB1 |
Monarch | ZEB1 |
1000_Genomes | ZEB1 |
Exome Variant Server | ZEB1 |
GNOMAD Browser | ENSG00000148516 |
Varsome Browser | ZEB1 |
Genomic Variants (DGV) | ZEB1 [DGVbeta] |
DECIPHER | ZEB1 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | ZEB1 |
| Mutations |
ICGC Data Portal | ZEB1 |
TCGA Data Portal | ZEB1 |
Broad Tumor Portal | ZEB1 |
OASIS Portal | ZEB1 [ Somatic mutations - Copy number] |
Cancer Gene: Census | ZEB1 |
Somatic Mutations in Cancer : COSMIC | ZEB1 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | ZEB1 |
Mutations and Diseases : HGMD | ZEB1 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search ZEB1 |
DgiDB (Drug Gene Interaction Database) | ZEB1 |
DoCM (Curated mutations) | ZEB1 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | ZEB1 (select a term) |
intoGen | ZEB1 |
Cancer3D | ZEB1(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 189909 609141 613270 |
Orphanet | 13990 13991 |
DisGeNET | ZEB1 |
Medgen | ZEB1 |
Genetic Testing Registry | ZEB1
|
NextProt | P37275 [Medical] |
GENETests | ZEB1 |
Target Validation | ZEB1 |
Huge Navigator |
ZEB1 [HugePedia] |
ClinGen | ZEB1 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | ZEB1 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA162409589 |
Pharm GKB Pathways | PA165984799 |
Pharos | P37275 |
Clinical trial | ZEB1 |
| Miscellaneous |
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canSAR (ICR) | ZEB1 (select the gene name) |
Harmonizome | ZEB1 |
DataMed Index | ZEB1 |
| Probes |
---|
| Litterature |
---|
PubMed | 464 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | ZEB1 |