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ZEB2 (zinc finger E-box binding homeobox 2)

Identity

Other namesHSPC082
SIP-1
SIP1
SMADIP1
ZFHX1B
HGNC (Hugo) ZEB2
LocusID (NCBI) 9839
Atlas_Id 45746
Location 2q22.3  [Link to chromosome band 2q22]
Location_base_pair Starts at 145141942 and ends at 145277958 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FXYD6 (11q23.3) / ZEB2 (2q22.3)HBG2 (11p15.4) / ZEB2 (2q22.3)NSMCE2 (8q24.13) / ZEB2 (2q22.3)
RNPS1 (16p13.3) / ZEB2 (2q22.3)ZEB2 (2q22.3) / GPD1L (3p22.3)ZEB2 (2q22.3) / JCHAIN (4q13.3)
ZEB2 (2q22.3) / PAFAH2 (1p36.11)ZEB2 (2q22.3) / PLCG1 (20q12)ZEB2 (2q22.3) / RBFOX1 (16p13.3)
FXYD6 11q23.3 / ZEB2 2q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZEB2   14881
Cards
Entrez_Gene (NCBI)ZEB2  9839  zinc finger E-box binding homeobox 2
AliasesHSPC082; SIP-1; SIP1; SMADIP1; 
ZFHX1B
GeneCards (Weizmann)ZEB2
Ensembl hg19 (Hinxton)ENSG00000169554 [Gene_View]  chr2:145141942-145277958 [Contig_View]  ZEB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169554 [Gene_View]  chr2:145141942-145277958 [Contig_View]  ZEB2 [Vega]
ICGC DataPortalENSG00000169554
TCGA cBioPortalZEB2
AceView (NCBI)ZEB2
Genatlas (Paris)ZEB2
WikiGenes9839
SOURCE (Princeton)ZEB2
Genomic and cartography
GoldenPath hg19 (UCSC)ZEB2  -     chr2:145141942-145277958 -  2q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZEB2  -     2q22.3   [Description]    (hg38-Dec_2013)
EnsemblZEB2 - 2q22.3 [CytoView hg19]  ZEB2 - 2q22.3 [CytoView hg38]
Mapping of homologs : NCBIZEB2 [Mapview hg19]  ZEB2 [Mapview hg38]
OMIM235730   605802   
Gene and transcription
Genbank (Entrez)AB011141 AB015341 AB056507 AB193095 AB193096
RefSeq transcript (Entrez)NM_001171653 NM_014795
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_016431 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)ZEB2
Cluster EST : UnigeneHs.34871 [ NCBI ]
CGAP (NCI)Hs.34871
Alternative Splicing GalleryENSG00000169554
Gene ExpressionZEB2 [ NCBI-GEO ]   ZEB2 [ EBI - ARRAY_EXPRESS ]   ZEB2 [ SEEK ]   ZEB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZEB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9839
GTEX Portal (Tissue expression)ZEB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60315 (Uniprot)
NextProtO60315  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60315
Splice isoforms : SwissVarO60315 (Swissvar)
PhosPhoSitePlusO60315
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Di19_Zn_binding_dom    Homeobox_dom    Homeodomain-like    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-Di19 (PF05605)   
Domain families : Pfam (NCBI)pfam05605   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
DMDM Disease mutations9839
Blocks (Seattle)ZEB2
PDB (SRS)2DA7   
PDB (PDBSum)2DA7   
PDB (IMB)2DA7   
PDB (RSDB)2DA7   
Structural Biology KnowledgeBase2DA7   
SCOP (Structural Classification of Proteins)2DA7   
CATH (Classification of proteins structures)2DA7   
SuperfamilyO60315
Human Protein AtlasENSG00000169554
Peptide AtlasO60315
HPRD05780
IPIIPI00872002   IPI00917827   IPI00783017   IPI00917377   IPI00916300   IPI00916584   IPI01018916   IPI00917381   IPI01018011   IPI01008972   IPI00917970   
Protein Interaction databases
DIP (DOE-UCLA)O60315
IntAct (EBI)O60315
FunCoupENSG00000169554
BioGRIDZEB2
STRING (EMBL)ZEB2
ZODIACZEB2
Ontologies - Pathways
QuickGOO60315
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  neural crest cell migration  somitogenesis  neural tube closure  DNA binding  protein binding  nucleus  transcription from RNA polymerase II promoter  nervous system development  phosphatase regulator activity  corpus callosum morphogenesis  hippocampus development  cell proliferation in forebrain  corticospinal tract morphogenesis  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  collateral sprouting  positive regulation of axonogenesis  mammillary axonal complex development  R-SMAD binding  melanocyte migration  positive regulation of lens fiber cell differentiation  regulation of melanosome organization  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  neural crest cell migration  somitogenesis  neural tube closure  DNA binding  protein binding  nucleus  transcription from RNA polymerase II promoter  nervous system development  phosphatase regulator activity  corpus callosum morphogenesis  hippocampus development  cell proliferation in forebrain  corticospinal tract morphogenesis  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  collateral sprouting  positive regulation of axonogenesis  mammillary axonal complex development  R-SMAD binding  melanocyte migration  positive regulation of lens fiber cell differentiation  regulation of melanosome organization  
Pathways : KEGGMicroRNAs in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkZEB2
Wikipedia pathwaysZEB2
Orthology - Evolution
OrthoDB9839
GeneTree (enSembl)ENSG00000169554
Phylogenetic Trees/Animal Genes : TreeFamZEB2
Homologs : HomoloGeneZEB2
Homology/Alignments : Family Browser (UCSC)ZEB2
Gene fusions - Rearrangements
Fusion: TCGAFXYD6 11q23.3 ZEB2 2q22.3 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerZEB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZEB2
dbVarZEB2
ClinVarZEB2
1000_GenomesZEB2 
Exome Variant ServerZEB2
ExAC (Exome Aggregation Consortium)ZEB2 (select the gene name)
Genetic variants : HAPMAP9839
Genomic Variants (DGV)ZEB2 [DGVbeta]
Mutations
ICGC Data PortalZEB2 
TCGA Data PortalZEB2 
Broad Tumor PortalZEB2
OASIS PortalZEB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZEB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch ZEB2
DgiDB (Drug Gene Interaction Database)ZEB2
DoCM (Curated mutations)ZEB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZEB2 (select a term)
intoGenZEB2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:145141942-145277958  ENSG00000169554
CONAN: Copy Number AnalysisZEB2 
Mutations and Diseases : HGMDZEB2
OMIM235730    605802   
MedgenZEB2
Genetic Testing Registry ZEB2
NextProtO60315 [Medical]
TSGene9839
GENETestsZEB2
Huge Navigator ZEB2 [HugePedia]
snp3D : Map Gene to Disease9839
BioCentury BCIQZEB2
ClinGenZEB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9839
Chemical/Pharm GKB GenePA162409612
Clinical trialZEB2
Miscellaneous
canSAR (ICR)ZEB2 (select the gene name)
Probes
Litterature
PubMed160 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZEB2
EVEXZEB2
GoPubMedZEB2
iHOPZEB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:14:44 CEST 2016

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