Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ZEB2 (zinc finger E-box binding homeobox 2)

Identity

Other namesHSPC082
SIP-1
SIP1
SMADIP1
ZFHX1B
HGNC (Hugo) ZEB2
LocusID (NCBI) 9839
Location 2q22.3
Location_base_pair Starts at 145141942 and ends at 145277958 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ZEB2   14881
Cards
Entrez_Gene (NCBI)ZEB2  9839  zinc finger E-box binding homeobox 2
GeneCards (Weizmann)ZEB2
Ensembl (Hinxton)ENSG00000169554 [Gene_View]  chr2:145141942-145277958 [Contig_View]  ZEB2 [Vega]
ICGC DataPortalENSG00000169554
AceView (NCBI)ZEB2
Genatlas (Paris)ZEB2
WikiGenes9839
SOURCE (Princeton)NM_001171653 NM_014795
Genomic and cartography
GoldenPath (UCSC)ZEB2  -  2q22.3   chr2:145141942-145277958 -  2q22.3   [Description]    (hg19-Feb_2009)
EnsemblZEB2 - 2q22.3 [CytoView]
Mapping of homologs : NCBIZEB2 [Mapview]
OMIM235730   605802   
Gene and transcription
Genbank (Entrez)AB011141 AB015341 AB056507 AB193095 AB193096
RefSeq transcript (Entrez)NM_001171653 NM_014795
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_016431 NT_005403 NW_001838859 NW_004929304
Consensus coding sequences : CCDS (NCBI)ZEB2
Cluster EST : UnigeneHs.34871 [ NCBI ]
CGAP (NCI)Hs.34871
Alternative Splicing : Fast-db (Paris)GSHG0045821
Alternative Splicing GalleryENSG00000169554
Gene ExpressionZEB2 [ NCBI-GEO ]     ZEB2 [ SEEK ]   ZEB2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60315 (Uniprot)
NextProtO60315  [Medical]
With graphics : InterProO60315
Splice isoforms : SwissVarO60315 (Swissvar)
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Di19_Zn_binding    Homeobox_dom    Homeodomain-like    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrO60315
Domain families : Pfam (Sanger)zf-Di19 (PF05605)   
Domain families : Pfam (NCBI)pfam05605   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
DMDM Disease mutations9839
Blocks (Seattle)O60315
PDB (SRS)2DA7   
PDB (PDBSum)2DA7   
PDB (IMB)2DA7   
PDB (RSDB)2DA7   
Human Protein AtlasENSG00000169554
Peptide AtlasO60315
HPRD05780
IPIIPI00872002   IPI00917827   IPI00783017   IPI00917377   IPI00916300   IPI00916584   IPI01018916   IPI00917381   IPI01018011   IPI01008972   IPI00917970   
Protein Interaction databases
DIP (DOE-UCLA)O60315
IntAct (EBI)O60315
FunCoupENSG00000169554
BioGRIDZEB2
IntegromeDBZEB2
STRING (EMBL)ZEB2
Ontologies - Pathways
QuickGOO60315
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  neural crest cell migration  somitogenesis  neural tube closure  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  nervous system development  phosphatase regulator activity  hippocampus development  cell proliferation in forebrain  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  sequence-specific DNA binding  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  R-SMAD binding  melanocyte migration  regulation of melanosome organization  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  neural crest cell migration  somitogenesis  neural tube closure  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  nervous system development  phosphatase regulator activity  hippocampus development  cell proliferation in forebrain  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  sequence-specific DNA binding  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  R-SMAD binding  melanocyte migration  regulation of melanosome organization  
Pathways : KEGGMicroRNAs in cancer   
Protein Interaction DatabaseZEB2
Wikipedia pathwaysZEB2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ZEB2
SNP (GeneSNP Utah)ZEB2
SNP : HGBaseZEB2
Genetic variants : HAPMAPZEB2
1000_GenomesZEB2 
ICGC programENSG00000169554 
CONAN: Copy Number AnalysisZEB2 
Somatic Mutations in Cancer : COSMICZEB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
DECIPHER (Syndromes)2:145141942-145277958
Mutations and Diseases : HGMDZEB2
OMIM235730    605802   
MedgenZEB2
GENETestsZEB2
Disease Genetic AssociationZEB2
Huge Navigator ZEB2 [HugePedia]  ZEB2 [HugeCancerGEM]
Genomic VariantsZEB2  ZEB2 [DGVbeta]
Exome VariantZEB2
dbVarZEB2
ClinVarZEB2
snp3D : Map Gene to Disease9839
General knowledge
Homologs : HomoloGeneZEB2
Homology/Alignments : Family Browser (UCSC)ZEB2
Phylogenetic Trees/Animal Genes : TreeFamZEB2
Chemical/Protein Interactions : CTD9839
Chemical/Pharm GKB GenePA162409612
Clinical trialZEB2
Cancer Resource (Charite)ENSG00000169554
Other databases
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
CoreMineZEB2
GoPubMedZEB2
iHOPZEB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 18:06:30 CET 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.