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ZEB2 (zinc finger E-box binding homeobox 2)

Identity

Alias_namesZFHX1B
zinc finger homeobox 1b
Alias_symbol (synonym)KIAA0569
SIP-1
SIP1
Other aliasHSPC082
SMADIP1
HGNC (Hugo) ZEB2
LocusID (NCBI) 9839
Atlas_Id 45746
Location 2q22.3  [Link to chromosome band 2q22]
Location_base_pair Starts at 144384375 and ends at 144520391 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FXYD6 (11q23.3) / ZEB2 (2q22.3)HBG2 (11p15.4) / ZEB2 (2q22.3)NSMCE2 (8q24.13) / ZEB2 (2q22.3)
RNPS1 (16p13.3) / ZEB2 (2q22.3)ZEB2 (2q22.3) / GPD1L (3p22.3)ZEB2 (2q22.3) / JCHAIN (4q13.3)
ZEB2 (2q22.3) / PAFAH2 (1p36.11)ZEB2 (2q22.3) / PLCG1 (20q12)ZEB2 (2q22.3) / RBFOX1 (16p13.3)
FXYD6 11q23.3 / ZEB2 2q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)


External links

Nomenclature
HGNC (Hugo)ZEB2   14881
Cards
Entrez_Gene (NCBI)ZEB2  9839  zinc finger E-box binding homeobox 2
AliasesHSPC082; SIP-1; SIP1; SMADIP1; 
ZFHX1B
GeneCards (Weizmann)ZEB2
Ensembl hg19 (Hinxton)ENSG00000169554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169554 [Gene_View]  chr2:144384375-144520391 [Contig_View]  ZEB2 [Vega]
ICGC DataPortalENSG00000169554
TCGA cBioPortalZEB2
AceView (NCBI)ZEB2
Genatlas (Paris)ZEB2
WikiGenes9839
SOURCE (Princeton)ZEB2
Genetics Home Reference (NIH)ZEB2
Genomic and cartography
GoldenPath hg38 (UCSC)ZEB2  -     chr2:144384375-144520391 -  2q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZEB2  -     2q22.3   [Description]    (hg19-Feb_2009)
EnsemblZEB2 - 2q22.3 [CytoView hg19]  ZEB2 - 2q22.3 [CytoView hg38]
Mapping of homologs : NCBIZEB2 [Mapview hg19]  ZEB2 [Mapview hg38]
OMIM235730   605802   
Gene and transcription
Genbank (Entrez)AB011141 AB015341 AB056507 AB193095 AB193096
RefSeq transcript (Entrez)NM_001171653 NM_014795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZEB2
Cluster EST : UnigeneHs.34871 [ NCBI ]
CGAP (NCI)Hs.34871
Alternative Splicing GalleryENSG00000169554
Gene ExpressionZEB2 [ NCBI-GEO ]   ZEB2 [ EBI - ARRAY_EXPRESS ]   ZEB2 [ SEEK ]   ZEB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZEB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9839
GTEX Portal (Tissue expression)ZEB2
Human Protein AtlasENSG00000169554-ZEB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60315   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60315  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60315
Splice isoforms : SwissVarO60315
PhosPhoSitePlusO60315
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Di19_Zn_binding_dom    Homeobox-like    Homeobox_dom    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-Di19 (PF05605)   
Domain families : Pfam (NCBI)pfam05605   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZEB2
DMDM Disease mutations9839
Blocks (Seattle)ZEB2
PDB (SRS)2DA7   
PDB (PDBSum)2DA7   
PDB (IMB)2DA7   
PDB (RSDB)2DA7   
Structural Biology KnowledgeBase2DA7   
SCOP (Structural Classification of Proteins)2DA7   
CATH (Classification of proteins structures)2DA7   
SuperfamilyO60315
Human Protein Atlas [tissue]ENSG00000169554-ZEB2 [tissue]
Peptide AtlasO60315
HPRD05780
IPIIPI00872002   IPI00917827   IPI00783017   IPI00917377   IPI00916300   IPI00916584   IPI01018916   IPI00917381   IPI01018011   IPI01008972   IPI00917970   
Protein Interaction databases
DIP (DOE-UCLA)O60315
IntAct (EBI)O60315
FunCoupENSG00000169554
BioGRIDZEB2
STRING (EMBL)ZEB2
ZODIACZEB2
Ontologies - Pathways
QuickGOO60315
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  neural crest cell migration  somitogenesis  neural tube closure  DNA binding  protein binding  nucleus  nucleolus  cytosol  transcription from RNA polymerase II promoter  nervous system development  phosphatase regulator activity  corpus callosum morphogenesis  hippocampus development  cell proliferation in forebrain  corticospinal tract morphogenesis  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  collateral sprouting  positive regulation of axonogenesis  mammillary axonal complex development  R-SMAD binding  melanocyte migration  positive regulation of lens fiber cell differentiation  regulation of melanosome organization  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  neural crest cell migration  somitogenesis  neural tube closure  DNA binding  protein binding  nucleus  nucleolus  cytosol  transcription from RNA polymerase II promoter  nervous system development  phosphatase regulator activity  corpus callosum morphogenesis  hippocampus development  cell proliferation in forebrain  corticospinal tract morphogenesis  positive regulation of Wnt signaling pathway  positive regulation of JUN kinase activity  positive regulation of melanocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of melanin biosynthetic process  developmental pigmentation  collateral sprouting  positive regulation of axonogenesis  mammillary axonal complex development  R-SMAD binding  melanocyte migration  positive regulation of lens fiber cell differentiation  regulation of melanosome organization  
Pathways : KEGGMicroRNAs in cancer   
NDEx NetworkZEB2
Atlas of Cancer Signalling NetworkZEB2
Wikipedia pathwaysZEB2
Orthology - Evolution
OrthoDB9839
GeneTree (enSembl)ENSG00000169554
Phylogenetic Trees/Animal Genes : TreeFamZEB2
HOVERGENO60315
HOGENOMO60315
Homologs : HomoloGeneZEB2
Homology/Alignments : Family Browser (UCSC)ZEB2
Gene fusions - Rearrangements
Fusion : MitelmanFXYD6/ZEB2 [11q23.3/2q22.3]  [t(2;11)(q22;q23)]  
Fusion: TCGA_MDACCFXYD6 11q23.3 ZEB2 2q22.3 LGG
Tumor Fusion PortalZEB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZEB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZEB2
dbVarZEB2
ClinVarZEB2
1000_GenomesZEB2 
Exome Variant ServerZEB2
ExAC (Exome Aggregation Consortium)ENSG00000169554
GNOMAD BrowserENSG00000169554
Genetic variants : HAPMAP9839
Genomic Variants (DGV)ZEB2 [DGVbeta]
DECIPHERZEB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZEB2 
Mutations
ICGC Data PortalZEB2 
TCGA Data PortalZEB2 
Broad Tumor PortalZEB2
OASIS PortalZEB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZEB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZEB2
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch ZEB2
DgiDB (Drug Gene Interaction Database)ZEB2
DoCM (Curated mutations)ZEB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZEB2 (select a term)
intoGenZEB2
Cancer3DZEB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM235730    605802   
Orphanet19888    19889   
DisGeNETZEB2
MedgenZEB2
Genetic Testing Registry ZEB2
NextProtO60315 [Medical]
TSGene9839
GENETestsZEB2
Target ValidationZEB2
Huge Navigator ZEB2 [HugePedia]
snp3D : Map Gene to Disease9839
BioCentury BCIQZEB2
ClinGenZEB2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9839
Chemical/Pharm GKB GenePA162409612
Clinical trialZEB2
Miscellaneous
canSAR (ICR)ZEB2 (select the gene name)
Probes
Litterature
PubMed180 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZEB2
EVEXZEB2
GoPubMedZEB2
iHOPZEB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:42:14 CET 2017

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