Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZFAT (zinc finger and AT-hook domain containing)

Identity

Alias_namesZNF406
ZFAT1
zinc finger protein 406
zinc finger and AT hook domain containing
Alias_symbol (synonym)KIAA1485
Other aliasAITD3
HGNC (Hugo) ZFAT
LocusID (NCBI) 57623
Atlas_Id 54797
Location 8q24.22  [Link to chromosome band 8q24]
Location_base_pair Starts at 135490031 and ends at 135708801 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COX18 (4q13.3) / ZFAT (8q24.22)EFR3A (8q24.22) / ZFAT (8q24.22)LIG3 (17q12) / ZFAT (8q24.22)
SPIDR (8q11.21) / ZFAT (8q24.22)ZFAT (8q24.22) / GSTO2 (10q25.1)ZFAT (8q24.22) / LOC148413 (1p36.33)
ZFAT (8q24.22) / S100A13 (1q21.3)EFR3A 8q24.22 / ZFAT 8q24.22LIG3 17q12 / ZFAT 8q24.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ZFAT   19899
Cards
Entrez_Gene (NCBI)ZFAT  57623  zinc finger and AT-hook domain containing
AliasesAITD3; ZFAT1; ZNF406
GeneCards (Weizmann)ZFAT
Ensembl hg19 (Hinxton)ENSG00000066827 [Gene_View]  chr8:135490031-135708801 [Contig_View]  ZFAT [Vega]
Ensembl hg38 (Hinxton)ENSG00000066827 [Gene_View]  chr8:135490031-135708801 [Contig_View]  ZFAT [Vega]
ICGC DataPortalENSG00000066827
TCGA cBioPortalZFAT
AceView (NCBI)ZFAT
Genatlas (Paris)ZFAT
WikiGenes57623
SOURCE (Princeton)ZFAT
Genetics Home Reference (NIH)ZFAT
Genomic and cartography
GoldenPath hg19 (UCSC)ZFAT  -     chr8:135490031-135708801 -  8q24.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZFAT  -     8q24.22   [Description]    (hg38-Dec_2013)
EnsemblZFAT - 8q24.22 [CytoView hg19]  ZFAT - 8q24.22 [CytoView hg38]
Mapping of homologs : NCBIZFAT [Mapview hg19]  ZFAT [Mapview hg38]
OMIM608175   610931   
Gene and transcription
Genbank (Entrez)AB040918 AB167738 AB167739 AB167740 AB167741
RefSeq transcript (Entrez)NM_001029939 NM_001167583 NM_001174157 NM_001174158 NM_001289394 NM_020863
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_016356 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)ZFAT
Cluster EST : UnigeneHs.446172 [ NCBI ]
CGAP (NCI)Hs.446172
Alternative Splicing GalleryENSG00000066827
Gene ExpressionZFAT [ NCBI-GEO ]   ZFAT [ EBI - ARRAY_EXPRESS ]   ZFAT [ SEEK ]   ZFAT [ MEM ]
Gene Expression Viewer (FireBrowse)ZFAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57623
GTEX Portal (Tissue expression)ZFAT
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P243   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P243  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P243
Splice isoforms : SwissVarQ9P243
PhosPhoSitePlusQ9P243
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZFAT
DMDM Disease mutations57623
Blocks (Seattle)ZFAT
PDB (SRS)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
PDB (PDBSum)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
PDB (IMB)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
PDB (RSDB)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
Structural Biology KnowledgeBase2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
SCOP (Structural Classification of Proteins)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
CATH (Classification of proteins structures)2ELM    2ELN    2ELO    2ELP    2ELQ    2ELR    2ELS    2ELT    2ELU    2ELV    2RSH    2RSI    2RSJ    2RUT    2RUU    2RUV    2RUW    2RUX    2RUY    2RUZ    2RV0    2RV1    2RV2    2RV3    2RV6    2RV7   
SuperfamilyQ9P243
Human Protein AtlasENSG00000066827
Peptide AtlasQ9P243
HPRD11712
IPIIPI00418220   IPI00657655   IPI00984760   IPI00646745   IPI00981710   IPI00973755   IPI00982757   IPI00980868   IPI00956293   IPI00979158   IPI01015141   IPI00978098   
Protein Interaction databases
DIP (DOE-UCLA)Q9P243
IntAct (EBI)Q9P243
FunCoupENSG00000066827
BioGRIDZFAT
STRING (EMBL)ZFAT
ZODIACZFAT
Ontologies - Pathways
QuickGOQ9P243
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  hematopoietic progenitor cell differentiation  transcription factor activity, sequence-specific DNA binding  nucleus  cytosol  transcription from RNA polymerase II promoter  multicellular organism development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  spongiotrophoblast layer development  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  hematopoietic progenitor cell differentiation  transcription factor activity, sequence-specific DNA binding  nucleus  cytosol  transcription from RNA polymerase II promoter  multicellular organism development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  spongiotrophoblast layer development  
NDEx NetworkZFAT
Atlas of Cancer Signalling NetworkZFAT
Wikipedia pathwaysZFAT
Orthology - Evolution
OrthoDB57623
GeneTree (enSembl)ENSG00000066827
Phylogenetic Trees/Animal Genes : TreeFamZFAT
HOVERGENQ9P243
HOGENOMQ9P243
Homologs : HomoloGeneZFAT
Homology/Alignments : Family Browser (UCSC)ZFAT
Gene fusions - Rearrangements
Fusion : MitelmanCOX18/ZFAT [4q13.3/8q24.22]  [t(4;8)(q13;q24)]  
Fusion : MitelmanEFR3A/ZFAT [8q24.22/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanLIG3/ZFAT [17q12/8q24.22]  [t(8;17)(q24;q12)]  
Fusion: TCGAEFR3A 8q24.22 ZFAT 8q24.22 LUAD
Fusion: TCGALIG3 17q12 ZFAT 8q24.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFAT
dbVarZFAT
ClinVarZFAT
1000_GenomesZFAT 
Exome Variant ServerZFAT
ExAC (Exome Aggregation Consortium)ZFAT (select the gene name)
Genetic variants : HAPMAP57623
Genomic Variants (DGV)ZFAT [DGVbeta]
DECIPHER (Syndromes)8:135490031-135708801  ENSG00000066827
CONAN: Copy Number AnalysisZFAT 
Mutations
ICGC Data PortalZFAT 
TCGA Data PortalZFAT 
Broad Tumor PortalZFAT
OASIS PortalZFAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFAT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFAT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFAT
DgiDB (Drug Gene Interaction Database)ZFAT
DoCM (Curated mutations)ZFAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFAT (select a term)
intoGenZFAT
Cancer3DZFAT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608175    610931   
Orphanet
MedgenZFAT
Genetic Testing Registry ZFAT
NextProtQ9P243 [Medical]
TSGene57623
GENETestsZFAT
Huge Navigator ZFAT [HugePedia]
snp3D : Map Gene to Disease57623
BioCentury BCIQZFAT
ClinGenZFAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57623
Chemical/Pharm GKB GenePA162409638
Clinical trialZFAT
Miscellaneous
canSAR (ICR)ZFAT (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFAT
EVEXZFAT
GoPubMedZFAT
iHOPZFAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:34:47 CET 2017

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