Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZFHX4 (zinc finger homeobox 4)

Identity

Alias_nameszinc finger homeodomain 4
Alias_symbol (synonym)ZFH4
FLJ20980
Other aliasZHF4
HGNC (Hugo) ZFHX4
LocusID (NCBI) 79776
Atlas_Id 43935
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 76681280 and ends at 76867285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMBRA1 (11p11.2) / ZFHX4 (8q21.11)GRHL2 (8q22.3) / ZFHX4 (8q21.11)H2AFY (5q31.1) / ZFHX4 (8q21.11)
ZFHX4 (8q21.11) / AMBRA1 (11p11.2)ZFHX4 (8q21.11) / GRM7 (3p26.1)ZFHX4 (8q21.11) / VRK1 (14q32.2)
GRHL2 8q22.3 / ZFHX4 8q21.11ZFHX4 8q21.11 / VRK1 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(8;8)(q21;q22) GRHL2/ZFHX4
t(8;14)(q21;q32) ZFHX4/VRK1


External links

Nomenclature
HGNC (Hugo)ZFHX4   30939
Cards
Entrez_Gene (NCBI)ZFHX4  79776  zinc finger homeobox 4
AliasesZFH4; ZHF4
GeneCards (Weizmann)ZFHX4
Ensembl hg19 (Hinxton)ENSG00000091656 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091656 [Gene_View]  ENSG00000091656 [Sequence]  chr8:76681280-76867285 [Contig_View]  ZFHX4 [Vega]
ICGC DataPortalENSG00000091656
TCGA cBioPortalZFHX4
AceView (NCBI)ZFHX4
Genatlas (Paris)ZFHX4
WikiGenes79776
SOURCE (Princeton)ZFHX4
Genetics Home Reference (NIH)ZFHX4
Genomic and cartography
GoldenPath hg38 (UCSC)ZFHX4  -     chr8:76681280-76867285 +  16q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFHX4  -     16q22.2   [Description]    (hg19-Feb_2009)
EnsemblZFHX4 - 16q22.2 [CytoView hg19]  ZFHX4 - 16q22.2 [CytoView hg38]
Mapping of homologs : NCBIZFHX4 [Mapview hg19]  ZFHX4 [Mapview hg38]
OMIM178300   606940   
Gene and transcription
Genbank (Entrez)AB083343 AF086273 AK024633 AK095274 AK131399
RefSeq transcript (Entrez)NM_024721
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFHX4
Cluster EST : UnigeneHs.458973 [ NCBI ]
CGAP (NCI)Hs.458973
Alternative Splicing GalleryENSG00000091656
Gene ExpressionZFHX4 [ NCBI-GEO ]   ZFHX4 [ EBI - ARRAY_EXPRESS ]   ZFHX4 [ SEEK ]   ZFHX4 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFHX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79776
GTEX Portal (Tissue expression)ZFHX4
Human Protein AtlasENSG00000091656-ZFHX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UP3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UP3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UP3
Splice isoforms : SwissVarQ86UP3
PhosPhoSitePlusQ86UP3
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Matrin/U1-like-C_Znf_C2H2    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  ZnF_U1 (SM00451)  
Conserved Domain (NCBI)ZFHX4
DMDM Disease mutations79776
Blocks (Seattle)ZFHX4
SuperfamilyQ86UP3
Human Protein Atlas [tissue]ENSG00000091656-ZFHX4 [tissue]
Peptide AtlasQ86UP3
HPRD09503
IPIIPI00941659   IPI00827871   IPI00973446   IPI00982042   IPI00976668   IPI00978044   IPI00984133   IPI00979795   
Protein Interaction databases
DIP (DOE-UCLA)Q86UP3
IntAct (EBI)Q86UP3
FunCoupENSG00000091656
BioGRIDZFHX4
STRING (EMBL)ZFHX4
ZODIACZFHX4
Ontologies - Pathways
QuickGOQ86UP3
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription, DNA-templated  regulation of transcription by RNA polymerase II  zinc ion binding  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription, DNA-templated  regulation of transcription by RNA polymerase II  zinc ion binding  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  
NDEx NetworkZFHX4
Atlas of Cancer Signalling NetworkZFHX4
Wikipedia pathwaysZFHX4
Orthology - Evolution
OrthoDB79776
GeneTree (enSembl)ENSG00000091656
Phylogenetic Trees/Animal Genes : TreeFamZFHX4
HOVERGENQ86UP3
HOGENOMQ86UP3
Homologs : HomoloGeneZFHX4
Homology/Alignments : Family Browser (UCSC)ZFHX4
Gene fusions - Rearrangements
Fusion : MitelmanGRHL2/ZFHX4 [8q22.3/8q21.11]  [t(8;8)(q21;q22)]  
Fusion : MitelmanZFHX4/VRK1 [8q21.11/14q32.2]  [t(8;14)(q21;q32)]  
Fusion PortalGRHL2 8q22.3 ZFHX4 8q21.11 BRCA
Fusion PortalZFHX4 8q21.11 VRK1 14q32.2 LUSC
Fusion : QuiverZFHX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFHX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFHX4
dbVarZFHX4
ClinVarZFHX4
1000_GenomesZFHX4 
Exome Variant ServerZFHX4
ExAC (Exome Aggregation Consortium)ENSG00000091656
GNOMAD BrowserENSG00000091656
Varsome BrowserZFHX4
Genetic variants : HAPMAP79776
Genomic Variants (DGV)ZFHX4 [DGVbeta]
DECIPHERZFHX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFHX4 
Mutations
ICGC Data PortalZFHX4 
TCGA Data PortalZFHX4 
Broad Tumor PortalZFHX4
OASIS PortalZFHX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFHX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFHX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFHX4
DgiDB (Drug Gene Interaction Database)ZFHX4
DoCM (Curated mutations)ZFHX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFHX4 (select a term)
intoGenZFHX4
Cancer3DZFHX4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178300    606940   
Orphanet
DisGeNETZFHX4
MedgenZFHX4
Genetic Testing Registry ZFHX4
NextProtQ86UP3 [Medical]
TSGene79776
GENETestsZFHX4
Target ValidationZFHX4
Huge Navigator ZFHX4 [HugePedia]
snp3D : Map Gene to Disease79776
BioCentury BCIQZFHX4
ClinGenZFHX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79776
Chemical/Pharm GKB GenePA134986366
Clinical trialZFHX4
Miscellaneous
canSAR (ICR)ZFHX4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFHX4
EVEXZFHX4
GoPubMedZFHX4
iHOPZFHX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:42:32 CEST 2018

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