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ZFP36L2 (ZFP36 ring finger protein like 2)

Identity

Alias_namesBRF2
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 2
Alias_symbol (synonym)ERF2
RNF162C
TIS11D
Other aliasERF-2
HGNC (Hugo) ZFP36L2
LocusID (NCBI) 678
Atlas_Id 52165
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 43222402 and ends at 43226606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY2 (5p15.31) / ZFP36L2 (2p21)LOC284889 () / ZFP36L2 (2p21)NFYA (6p21.1) / ZFP36L2 (2p21)
SOX11 (2p25.2) / ZFP36L2 (2p21)U2AF2 (19q13.42) / ZFP36L2 (2p21)ZFP36L2 (2p21) / LRRC6 (8q24.22)
ZFP36L2 (2p21) / RPL36 (19p13.3)ZFP36L2 (2p21) / SLAIN2 (4p11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZFP36L2   1108
Cards
Entrez_Gene (NCBI)ZFP36L2  678  ZFP36 ring finger protein like 2
AliasesBRF2; ERF-2; ERF2; RNF162C; 
TIS11D
GeneCards (Weizmann)ZFP36L2
Ensembl hg19 (Hinxton)ENSG00000152518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152518 [Gene_View]  chr2:43222402-43226606 [Contig_View]  ZFP36L2 [Vega]
ICGC DataPortalENSG00000152518
TCGA cBioPortalZFP36L2
AceView (NCBI)ZFP36L2
Genatlas (Paris)ZFP36L2
WikiGenes678
SOURCE (Princeton)ZFP36L2
Genetics Home Reference (NIH)ZFP36L2
Genomic and cartography
GoldenPath hg38 (UCSC)ZFP36L2  -     chr2:43222402-43226606 -  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFP36L2  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblZFP36L2 - 2p21 [CytoView hg19]  ZFP36L2 - 2p21 [CytoView hg38]
Mapping of homologs : NCBIZFP36L2 [Mapview hg19]  ZFP36L2 [Mapview hg38]
OMIM612053   
Gene and transcription
Genbank (Entrez)BC005010 BC020369 BE222042 BI489986 BI548620
RefSeq transcript (Entrez)NM_006887
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFP36L2
Cluster EST : UnigeneHs.503093 [ NCBI ]
CGAP (NCI)Hs.503093
Alternative Splicing GalleryENSG00000152518
Gene ExpressionZFP36L2 [ NCBI-GEO ]   ZFP36L2 [ EBI - ARRAY_EXPRESS ]   ZFP36L2 [ SEEK ]   ZFP36L2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFP36L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)678
GTEX Portal (Tissue expression)ZFP36L2
Human Protein AtlasENSG00000152518-ZFP36L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47974   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47974  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47974
Splice isoforms : SwissVarP47974
PhosPhoSitePlusP47974
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Tis11B_N    Znf_CCCH   
Domain families : Pfam (Sanger)Tis11B_N (PF04553)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam04553    pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)ZFP36L2
DMDM Disease mutations678
Blocks (Seattle)ZFP36L2
PDB (SRS)1RGO   
PDB (PDBSum)1RGO   
PDB (IMB)1RGO   
PDB (RSDB)1RGO   
Structural Biology KnowledgeBase1RGO   
SCOP (Structural Classification of Proteins)1RGO   
CATH (Classification of proteins structures)1RGO   
SuperfamilyP47974
Human Protein Atlas [tissue]ENSG00000152518-ZFP36L2 [tissue]
Peptide AtlasP47974
HPRD18319
IPIIPI00604786   IPI00977845   
Protein Interaction databases
DIP (DOE-UCLA)P47974
IntAct (EBI)P47974
FunCoupENSG00000152518
BioGRIDZFP36L2
STRING (EMBL)ZFP36L2
ZODIACZFP36L2
Ontologies - Pathways
QuickGOP47974
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  DNA binding  transcription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  cytoplasm  cytosol  regulation of transcription, DNA-templated  mRNA catabolic process  cell proliferation  response to wounding  AU-rich element binding  hemopoiesis  intracellular ribonucleoprotein complex  T cell differentiation in thymus  somatic stem cell population maintenance  mRNA 3'-UTR AU-rich region binding  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  regulation of B cell differentiation  negative regulation of fat cell differentiation  metal ion binding  somatic stem cell division  definitive hemopoiesis  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  ERK1 and ERK2 cascade  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to transforming growth factor beta stimulus  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of mitotic cell cycle phase transition  cellular response to phorbol 13-acetate 12-myristate  negative regulation of stem cell differentiation  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  DNA binding  transcription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  cytoplasm  cytosol  regulation of transcription, DNA-templated  mRNA catabolic process  cell proliferation  response to wounding  AU-rich element binding  hemopoiesis  intracellular ribonucleoprotein complex  T cell differentiation in thymus  somatic stem cell population maintenance  mRNA 3'-UTR AU-rich region binding  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  regulation of B cell differentiation  negative regulation of fat cell differentiation  metal ion binding  somatic stem cell division  definitive hemopoiesis  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  ERK1 and ERK2 cascade  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to transforming growth factor beta stimulus  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of mitotic cell cycle phase transition  cellular response to phorbol 13-acetate 12-myristate  negative regulation of stem cell differentiation  
NDEx NetworkZFP36L2
Atlas of Cancer Signalling NetworkZFP36L2
Wikipedia pathwaysZFP36L2
Orthology - Evolution
OrthoDB678
GeneTree (enSembl)ENSG00000152518
Phylogenetic Trees/Animal Genes : TreeFamZFP36L2
HOVERGENP47974
HOGENOMP47974
Homologs : HomoloGeneZFP36L2
Homology/Alignments : Family Browser (UCSC)ZFP36L2
Gene fusions - Rearrangements
Tumor Fusion PortalZFP36L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFP36L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFP36L2
dbVarZFP36L2
ClinVarZFP36L2
1000_GenomesZFP36L2 
Exome Variant ServerZFP36L2
ExAC (Exome Aggregation Consortium)ENSG00000152518
GNOMAD BrowserENSG00000152518
Genetic variants : HAPMAP678
Genomic Variants (DGV)ZFP36L2 [DGVbeta]
DECIPHERZFP36L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFP36L2 
Mutations
ICGC Data PortalZFP36L2 
TCGA Data PortalZFP36L2 
Broad Tumor PortalZFP36L2
OASIS PortalZFP36L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFP36L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFP36L2
intOGen PortalZFP36L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFP36L2
DgiDB (Drug Gene Interaction Database)ZFP36L2
DoCM (Curated mutations)ZFP36L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFP36L2 (select a term)
intoGenZFP36L2
Cancer3DZFP36L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612053   
Orphanet
DisGeNETZFP36L2
MedgenZFP36L2
Genetic Testing Registry ZFP36L2
NextProtP47974 [Medical]
TSGene678
GENETestsZFP36L2
Target ValidationZFP36L2
Huge Navigator ZFP36L2 [HugePedia]
snp3D : Map Gene to Disease678
BioCentury BCIQZFP36L2
ClinGenZFP36L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD678
Chemical/Pharm GKB GenePA35028
Clinical trialZFP36L2
Miscellaneous
canSAR (ICR)ZFP36L2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFP36L2
EVEXZFP36L2
GoPubMedZFP36L2
iHOPZFP36L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:42:16 CET 2017

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