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ZFP36L2 (ZFP36 ring finger protein like 2)

Identity

Alias (NCBI)BRF2
ERF-2
ERF2
RNF162C
TIS11D
HGNC (Hugo) ZFP36L2
HGNC Alias symbERF2
RNF162C
TIS11D
HGNC Previous nameBRF2
HGNC Previous namebutyrate response factor 2 (EGF-response factor 2)
 zinc finger protein 36, C3H type-like 2
LocusID (NCBI) 678
Atlas_Id 52165
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 43222402 and ends at 43226606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY2 (5p15.31) / ZFP36L2 (2p21)LOC284889 () / ZFP36L2 (2p21)NFYA (6p21.1) / ZFP36L2 (2p21)
SOX11 (2p25.2) / ZFP36L2 (2p21)U2AF2 (19q13.42) / ZFP36L2 (2p21)ZFP36L2 (2p21) / LRRC6 (8q24.22)
ZFP36L2 (2p21) / RPL36 (19p13.3)ZFP36L2 (2p21) / SLAIN2 (4p11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;2)(p34;p21) SFPQ/ZFP36L2
t(2;14)(p21;q11) ZFP36L2/TRA
t(X;2)(q13;p21) NONO/ZFP36L2


External links

 

Nomenclature
HGNC (Hugo)ZFP36L2   1108
Cards
Entrez_Gene (NCBI)ZFP36L2    ZFP36 ring finger protein like 2
AliasesBRF2; ERF-2; ERF2; RNF162C; 
TIS11D
GeneCards (Weizmann)ZFP36L2
Ensembl hg19 (Hinxton)ENSG00000152518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152518 [Gene_View]  ENSG00000152518 [Sequence]  chr2:43222402-43226606 [Contig_View]  ZFP36L2 [Vega]
ICGC DataPortalENSG00000152518
TCGA cBioPortalZFP36L2
AceView (NCBI)ZFP36L2
Genatlas (Paris)ZFP36L2
SOURCE (Princeton)ZFP36L2
Genetics Home Reference (NIH)ZFP36L2
Genomic and cartography
GoldenPath hg38 (UCSC)ZFP36L2  -     chr2:43222402-43226606 -  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFP36L2  -     2p21   [Description]    (hg19-Feb_2009)
GoldenPathZFP36L2 - 2p21 [CytoView hg19]  ZFP36L2 - 2p21 [CytoView hg38]
ImmunoBaseENSG00000152518
Genome Data Viewer NCBIZFP36L2 [Mapview hg19]  
OMIM612053   
Gene and transcription
Genbank (Entrez)BC005010 BC020369 BE222042 BI489986 BI548620
RefSeq transcript (Entrez)NM_006887
Consensus coding sequences : CCDS (NCBI)ZFP36L2
Gene ExpressionZFP36L2 [ NCBI-GEO ]   ZFP36L2 [ EBI - ARRAY_EXPRESS ]   ZFP36L2 [ SEEK ]   ZFP36L2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFP36L2 [ Firebrowse - Broad ]
GenevisibleExpression of ZFP36L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)678
GTEX Portal (Tissue expression)ZFP36L2
Human Protein AtlasENSG00000152518-ZFP36L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47974   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47974  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47974
PhosPhoSitePlusP47974
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Tis11B_N    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)Tis11B_N (PF04553)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam04553    pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)ZFP36L2
PDB (RSDB)1RGO   
PDB Europe1RGO   
PDB (PDBSum)1RGO   
PDB (IMB)1RGO   
Structural Biology KnowledgeBase1RGO   
SCOP (Structural Classification of Proteins)1RGO   
CATH (Classification of proteins structures)1RGO   
SuperfamilyP47974
AlphaFold pdb e-kbP47974   
Human Protein Atlas [tissue]ENSG00000152518-ZFP36L2 [tissue]
HPRD18319
Protein Interaction databases
DIP (DOE-UCLA)P47974
IntAct (EBI)P47974
BioGRIDZFP36L2
STRING (EMBL)ZFP36L2
ZODIACZFP36L2
Ontologies - Pathways
QuickGOP47974
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  RNA binding  protein binding  nucleus  cytoplasm  mRNA catabolic process  response to wounding  hemopoiesis  T cell differentiation in thymus  somatic stem cell population maintenance  mRNA 3'-UTR AU-rich region binding  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  regulation of B cell differentiation  negative regulation of fat cell differentiation  metal ion binding  somatic stem cell division  definitive hemopoiesis  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  ERK1 and ERK2 cascade  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to transforming growth factor beta stimulus  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of mitotic cell cycle phase transition  negative regulation of stem cell differentiation  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  RNA binding  protein binding  nucleus  cytoplasm  mRNA catabolic process  response to wounding  hemopoiesis  T cell differentiation in thymus  somatic stem cell population maintenance  mRNA 3'-UTR AU-rich region binding  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  regulation of B cell differentiation  negative regulation of fat cell differentiation  metal ion binding  somatic stem cell division  definitive hemopoiesis  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  ERK1 and ERK2 cascade  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to transforming growth factor beta stimulus  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of mitotic cell cycle phase transition  negative regulation of stem cell differentiation  
NDEx NetworkZFP36L2
Atlas of Cancer Signalling NetworkZFP36L2
Wikipedia pathwaysZFP36L2
Orthology - Evolution
OrthoDB678
GeneTree (enSembl)ENSG00000152518
Phylogenetic Trees/Animal Genes : TreeFamZFP36L2
Homologs : HomoloGeneZFP36L2
Homology/Alignments : Family Browser (UCSC)ZFP36L2
Gene fusions - Rearrangements
Fusion : QuiverZFP36L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFP36L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFP36L2
dbVarZFP36L2
ClinVarZFP36L2
MonarchZFP36L2
1000_GenomesZFP36L2 
Exome Variant ServerZFP36L2
GNOMAD BrowserENSG00000152518
Varsome BrowserZFP36L2
ACMGZFP36L2 variants
VarityP47974
Genomic Variants (DGV)ZFP36L2 [DGVbeta]
DECIPHERZFP36L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFP36L2 
Mutations
ICGC Data PortalZFP36L2 
TCGA Data PortalZFP36L2 
Broad Tumor PortalZFP36L2
OASIS PortalZFP36L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFP36L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZFP36L2
Mutations and Diseases : HGMDZFP36L2
intOGen PortalZFP36L2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZFP36L2
DgiDB (Drug Gene Interaction Database)ZFP36L2
DoCM (Curated mutations)ZFP36L2
CIViC (Clinical Interpretations of Variants in Cancer)ZFP36L2
Cancer3DZFP36L2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612053   
Orphanet
DisGeNETZFP36L2
MedgenZFP36L2
Genetic Testing Registry ZFP36L2
NextProtP47974 [Medical]
GENETestsZFP36L2
Target ValidationZFP36L2
Huge Navigator ZFP36L2 [HugePedia]
ClinGenZFP36L2
Clinical trials, drugs, therapy
MyCancerGenomeZFP36L2
Protein Interactions : CTDZFP36L2
Pharm GKB GenePA35028
PharosP47974
Clinical trialZFP36L2
Miscellaneous
canSAR (ICR)ZFP36L2
HarmonizomeZFP36L2
DataMed IndexZFP36L2
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZFP36L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:38:57 CEST 2021

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