ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase)

2015-10-01  

Identity

HGNC
ZFP91
LOCATION
11q12.1
LOCUSID
80829
ALIAS
DMS-8,DSM-8,DSM8,FKSG11,PZF,ZFP-91,ZNF757
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80829
HGNC: 14983
Ensembl: ENSG00000186660

Variants:

dbSNP: 80829
ClinVar: 80829
TCGA: ENSG00000186660
COSMIC: ZFP91

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186660ENST00000316059Q96JP5
ENSG00000186660ENST00000316059A0A024R4Z1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206827672010An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination.28
285302362017pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.22
127389862003Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia.16
271445162016Zinc finger protein 91 (ZFP91) activates HIF-1α via NF-κB/p65 to promote proliferation and tumorigenesis of colon cancer.11
208047342010Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway.10
242726752014ZFP91-a newly described gene potentially involved in prostate pathology.7
294718912018miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91.6
279750572016ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer.3
301823662018Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome.1

Citation

Dessen P

ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55499/zfp91