ZFPM1 (zinc finger protein, FOG family member 1)

2016-05-01  

Identity

HGNC
LOCATION
16q24.2
LOCUSID
ALIAS
FOG,FOG1,ZC2HC11A,ZNF408,ZNF89A
FUSION GENES

Other Information

Locus ID:

NCBI: 161882
MIM: 601950
HGNC: 19762
Ensembl: ENSG00000179588

Variants:

dbSNP: 161882
ClinVar: 161882
TCGA: ENSG00000179588
COSMIC: ZFPM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179588ENST00000319555Q8IX07
ENSG00000179588ENST00000562437A0A087WWQ0
ENSG00000179588ENST00000563351A0A087X1H8
ENSG00000179588ENST00000569086A0A087WZP1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
122003642002X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.45
210477982011Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.45
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
161271622005Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis.28
156444352005Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
180637542008Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation.14
265035842015Identification of four new susceptibility loci for testicular germ cell tumour.14
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
124832982003Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.11

Citation

Dessen P

ZFPM1 (zinc finger protein, FOG family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55763/zfpm1