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ZFPM2 (zinc finger protein, FOG family member 2)

Identity

Alias (NCBI)DIH3
FOG2
SRXY9
ZC2HC11B
ZNF89B
hFOG-2
HGNC (Hugo) ZFPM2
HGNC Alias symbFOG2
hFOG-2
ZNF89B
ZC2HC11B
HGNC Previous namezinc finger protein, multitype 2
LocusID (NCBI) 23414
Atlas_Id 431
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 105318438 and ends at 105804539 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RRM2B (8q22.3) / ZFPM2 (8q23.1)RUNX1 (21q22.12) / ZFPM2 (8q23.1)TRAM1 (8q13.3) / ZFPM2 (8q23.1)
ZFPM2 (8q23.1) / BOLA2 (16p11.2)ZFPM2 (8q23.1) / ELF5 (11p13)ZFPM2 (8q23.1) / ZFPM2 (8q23.1)
RRM2B 8q22.3 / ZFPM2 8q23.1TRAM1 8q13.3 / ZFPM2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 11 ]
  inv(3)(p12q26) ?/MECOM
inv(3)(q23q26) ?/MECOM
t(3;3)(p24;q26) ?/MECOM
t(3;5)(q26;q34) ?/MECOM
t(3;6)(q25;q26) ?/MECOM
t(3;9)(q26;p23) ?/MECOM
t(3;11)(q26;p15) ?/MECOM
t(3;12)(q26;q21) ?/MECOM
t(3;17)(q26;q22) ?/MECOM
t(3;18)(q26;q11) ?/MECOM
t(8;21)(q23;q22) RUNX1/ZFPM2


External links

 

Nomenclature
HGNC (Hugo)ZFPM2   16700
Cards
Entrez_Gene (NCBI)ZFPM2    zinc finger protein, FOG family member 2
AliasesDIH3; FOG2; SRXY9; ZC2HC11B; 
ZNF89B; hFOG-2
GeneCards (Weizmann)ZFPM2
Ensembl hg19 (Hinxton)ENSG00000169946 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169946 [Gene_View]  ENSG00000169946 [Sequence]  chr8:105318438-105804539 [Contig_View]  ZFPM2 [Vega]
ICGC DataPortalENSG00000169946
TCGA cBioPortalZFPM2
AceView (NCBI)ZFPM2
Genatlas (Paris)ZFPM2
SOURCE (Princeton)ZFPM2
Genetics Home Reference (NIH)ZFPM2
Genomic and cartography
GoldenPath hg38 (UCSC)ZFPM2  -     chr8:105318438-105804539 +  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFPM2  -     8q23.1   [Description]    (hg19-Feb_2009)
GoldenPathZFPM2 - 8q23.1 [CytoView hg19]  ZFPM2 - 8q23.1 [CytoView hg38]
ImmunoBaseENSG00000169946
Genome Data Viewer NCBIZFPM2 [Mapview hg19]  
OMIM187500   603693   610187   616067   
Gene and transcription
Genbank (Entrez)AB073894 AF119334 AK296997 AK303058 AK316426
RefSeq transcript (Entrez)NM_001362836 NM_001362837 NM_012082
Consensus coding sequences : CCDS (NCBI)ZFPM2
Gene ExpressionZFPM2 [ NCBI-GEO ]   ZFPM2 [ EBI - ARRAY_EXPRESS ]   ZFPM2 [ SEEK ]   ZFPM2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFPM2 [ Firebrowse - Broad ]
GenevisibleExpression of ZFPM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23414
GTEX Portal (Tissue expression)ZFPM2
Human Protein AtlasENSG00000169946-ZFPM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WW38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WW38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WW38
PhosPhoSitePlusQ8WW38
Domaine pattern : Prosite (Expaxy)ZF_CCHC_FOG (PS51810)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)FOG    ZF_CCHC_FOG    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZFPM2
SuperfamilyQ8WW38
AlphaFold pdb e-kbQ8WW38   
Human Protein Atlas [tissue]ENSG00000169946-ZFPM2 [tissue]
HPRD04737
Protein Interaction databases
DIP (DOE-UCLA)Q8WW38
IntAct (EBI)Q8WW38
BioGRIDZFPM2
STRING (EMBL)ZFPM2
ZODIACZFPM2
Ontologies - Pathways
QuickGOQ8WW38
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  vasculogenesis  in utero embryonic development  outflow tract septum morphogenesis  right ventricular cardiac muscle tissue morphogenesis  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  gonadal mesoderm development  heart development  blood coagulation  transcription factor binding  zinc ion binding  cell differentiation  lung development  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  embryonic organ development  positive regulation of cardiac muscle cell proliferation  ventricular septum morphogenesis  negative regulation of cell death  RNA polymerase II-specific DNA-binding transcription factor binding  positive regulation of male gonad development  negative regulation of female gonad development  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  vasculogenesis  in utero embryonic development  outflow tract septum morphogenesis  right ventricular cardiac muscle tissue morphogenesis  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  gonadal mesoderm development  heart development  blood coagulation  transcription factor binding  zinc ion binding  cell differentiation  lung development  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  embryonic organ development  positive regulation of cardiac muscle cell proliferation  ventricular septum morphogenesis  negative regulation of cell death  RNA polymerase II-specific DNA-binding transcription factor binding  positive regulation of male gonad development  negative regulation of female gonad development  
Pathways : KEGGMicroRNAs in cancer   
NDEx NetworkZFPM2
Atlas of Cancer Signalling NetworkZFPM2
Wikipedia pathwaysZFPM2
Orthology - Evolution
OrthoDB23414
GeneTree (enSembl)ENSG00000169946
Phylogenetic Trees/Animal Genes : TreeFamZFPM2
Homologs : HomoloGeneZFPM2
Homology/Alignments : Family Browser (UCSC)ZFPM2
Gene fusions - Rearrangements
Fusion : MitelmanRRM2B/ZFPM2 [8q22.3/8q23.1]  
Fusion : MitelmanRUNX1/ZFPM2 [21q22.12/8q23.1]  
Fusion : MitelmanTRAM1/ZFPM2 [8q13.3/8q23.1]  
Fusion : MitelmanZFPM2/ELF5 [8q23.1/11p13]  
Fusion : QuiverZFPM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFPM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFPM2
dbVarZFPM2
ClinVarZFPM2
MonarchZFPM2
1000_GenomesZFPM2 
Exome Variant ServerZFPM2
GNOMAD BrowserENSG00000169946
Varsome BrowserZFPM2
ACMGZFPM2 variants
VarityQ8WW38
Genomic Variants (DGV)ZFPM2 [DGVbeta]
DECIPHERZFPM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFPM2 
Mutations
ICGC Data PortalZFPM2 
TCGA Data PortalZFPM2 
Broad Tumor PortalZFPM2
OASIS PortalZFPM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFPM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZFPM2
Mutations and Diseases : HGMDZFPM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZFPM2
DgiDB (Drug Gene Interaction Database)ZFPM2
DoCM (Curated mutations)ZFPM2
CIViC (Clinical Interpretations of Variants in Cancer)ZFPM2
Cancer3DZFPM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187500    603693    610187    616067   
Orphanet506    820    19642   
DisGeNETZFPM2
MedgenZFPM2
Genetic Testing Registry ZFPM2
NextProtQ8WW38 [Medical]
GENETestsZFPM2
Target ValidationZFPM2
Huge Navigator ZFPM2 [HugePedia]
ClinGenZFPM2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeZFPM2
Protein Interactions : CTDZFPM2
Pharm GKB GenePA134947303
PharosQ8WW38
Clinical trialZFPM2
Miscellaneous
canSAR (ICR)ZFPM2
HarmonizomeZFPM2
DataMed IndexZFPM2
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZFPM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:38:59 CEST 2021

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