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ZFPM2 (zinc finger protein, FOG family member 2)

Identity

Other namesDIH3
FOG2
SRXY9
ZC2HC11B
ZNF89B
hFOG-2
HGNC (Hugo) ZFPM2
LocusID (NCBI) 23414
Atlas_Id 431
Location 8q23.1
Location_base_pair Starts at 106331147 and ends at 106816767 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RRM2B (8q22.3) / ZFPM2 (8q23.1)RUNX1 (21q22.12) / ZFPM2 (8q23.1)TRAM1 (8q13.3) / ZFPM2 (8q23.1)
ZFPM2 (8q23.1) / BOLA2 (16p11.2)ZFPM2 (8q23.1) / ELF5 (11p13)ZFPM2 (8q23.1) / ZFPM2 (8q23.1)
RRM2B 8q22.3 / ZFPM2 8q23.1TRAM1 8q13.3 / ZFPM2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 11 ]
  inv(3)(p12q26) ?/MECOM
inv(3)(q23q26) ?/MECOM
t(3;3)(p24;q26) ?/MECOM
t(3;5)(q26;q34) ?/MECOM
t(3;6)(q25;q26) ?/MECOM
t(3;9)(q26;p23) ?/MECOM
t(3;11)(q26;p15) ?/MECOM
t(3;12)(q26;q21) ?/MECOM
t(3;17)(q26;q22) ?/MECOM
t(3;18)(q26;q11) ?/MECOM
t(8;21)(q23;q22) RUNX1/ZFPM2

External links

Nomenclature
HGNC (Hugo)ZFPM2   16700
Cards
Entrez_Gene (NCBI)ZFPM2  23414  zinc finger protein, FOG family member 2
GeneCards (Weizmann)ZFPM2
Ensembl hg19 (Hinxton)ENSG00000169946 [Gene_View]  chr8:106331147-106816767 [Contig_View]  ZFPM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169946 [Gene_View]  chr8:106331147-106816767 [Contig_View]  ZFPM2 [Vega]
ICGC DataPortalENSG00000169946
TCGA cBioPortalZFPM2
AceView (NCBI)ZFPM2
Genatlas (Paris)ZFPM2
WikiGenes23414
SOURCE (Princeton)ZFPM2
Genomic and cartography
GoldenPath hg19 (UCSC)ZFPM2  -     chr8:106331147-106816767 +  8q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZFPM2  -     8q23.1   [Description]    (hg38-Dec_2013)
EnsemblZFPM2 - 8q23.1 [CytoView hg19]  ZFPM2 - 8q23.1 [CytoView hg38]
Mapping of homologs : NCBIZFPM2 [Mapview hg19]  ZFPM2 [Mapview hg38]
OMIM187500   603693   610187   616067   
Gene and transcription
Genbank (Entrez)AB073894 AF119334 AK296997 AK303058 AK316426
RefSeq transcript (Entrez)NM_012082
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_011723 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)ZFPM2
Cluster EST : UnigeneHs.431009 [ NCBI ]
CGAP (NCI)Hs.431009
Alternative Splicing : Fast-db (Paris)GSHG0029195
Alternative Splicing GalleryENSG00000169946
Gene ExpressionZFPM2 [ NCBI-GEO ]   ZFPM2 [ EBI - ARRAY_EXPRESS ]   ZFPM2 [ SEEK ]   ZFPM2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFPM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)23414
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WW38 (Uniprot)
NextProtQ8WW38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WW38
Splice isoforms : SwissVarQ8WW38 (Swissvar)
PhosPhoSitePlusQ8WW38
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations23414
Blocks (Seattle)ZFPM2
SuperfamilyQ8WW38
Human Protein AtlasENSG00000169946
Peptide AtlasQ8WW38
HPRD04737
IPIIPI00015802   IPI00410662   IPI01013613   IPI00978516   IPI00977707   
Protein Interaction databases
DIP (DOE-UCLA)Q8WW38
IntAct (EBI)Q8WW38
FunCoupENSG00000169946
BioGRIDZFPM2
STRING (EMBL)ZFPM2
ZODIACZFPM2
Ontologies - Pathways
QuickGOQ8WW38
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II transcription factor binding  RNA polymerase II transcription coactivator activity  vasculogenesis  in utero embryonic development  outflow tract septum morphogenesis  right ventricular cardiac muscle tissue morphogenesis  DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  transcription, DNA-templated  gonadal mesoderm development  blood coagulation  transcription factor binding  zinc ion binding  lung development  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic organ development  ventricular septum morphogenesis  negative regulation of cell death  positive regulation of male gonad development  negative regulation of female gonad development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II transcription factor binding  RNA polymerase II transcription coactivator activity  vasculogenesis  in utero embryonic development  outflow tract septum morphogenesis  right ventricular cardiac muscle tissue morphogenesis  DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  transcription, DNA-templated  gonadal mesoderm development  blood coagulation  transcription factor binding  zinc ion binding  lung development  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic organ development  ventricular septum morphogenesis  negative regulation of cell death  positive regulation of male gonad development  negative regulation of female gonad development  
Pathways : KEGGMicroRNAs in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkZFPM2
Wikipedia pathwaysZFPM2
Orthology - Evolution
OrthoDB23414
GeneTree (enSembl)ENSG00000169946
Phylogenetic Trees/Animal Genes : TreeFamZFPM2
Homologs : HomoloGeneZFPM2
Homology/Alignments : Family Browser (UCSC)ZFPM2
Gene fusions - Rearrangements
Fusion: TCGARRM2B 8q22.3 ZFPM2 8q23.1 BRCA
Fusion: TCGATRAM1 8q13.3 ZFPM2 8q23.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerZFPM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFPM2
dbVarZFPM2
ClinVarZFPM2
1000_GenomesZFPM2 
Exome Variant ServerZFPM2
ExAC (Exome Aggregation Consortium)ZFPM2 (select the gene name)
SNP (GeneSNP Utah)ZFPM2
SNP : HGBaseZFPM2
Genetic variants : HAPMAPZFPM2
Genomic Variants (DGV)ZFPM2 [DGVbeta]
Mutations
ICGC Data PortalZFPM2 
TCGA Data PortalZFPM2 
Broad Tumor PortalZFPM2
OASIS PortalZFPM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFPM2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFPM2
DgiDB (Drug Gene Interaction Database)ZFPM2
DoCM (Curated mutations)ZFPM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFPM2 (select a term)
intoGenZFPM2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:106331147-106816767
CONAN: Copy Number AnalysisZFPM2 
Mutations and Diseases : HGMDZFPM2
OMIM187500    603693    610187    616067   
MedgenZFPM2
Genetic Testing Registry ZFPM2
NextProtQ8WW38 [Medical]
TSGene23414
GENETestsZFPM2
Huge Navigator ZFPM2 [HugePedia]  ZFPM2 [HugeCancerGEM]
snp3D : Map Gene to Disease23414
BioCentury BCIQZFPM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23414
Chemical/Pharm GKB GenePA134947303
Clinical trialZFPM2
Miscellaneous
canSAR (ICR)ZFPM2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFPM2
GoPubMedZFPM2
iHOPZFPM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:10:34 CEST 2016

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