Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZFYVE1 (zinc finger FYVE-type containing 1)

Identity

Alias_namesZNFN2A1
zinc finger protein, subfamily 2A (FYVE domain containing), 1
zinc finger, FYVE domain containing 1
Alias_symbol (synonym)DFCP1
KIAA1589
TAFF1
PPP1R172
Other aliasSR3
HGNC (Hugo) ZFYVE1
LocusID (NCBI) 53349
Atlas_Id 75951
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 72969445 and ends at 73027212 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKAP13 (15q25.3) / ZFYVE1 (14q24.2)ZFYVE1 (14q24.2) / MBP (18q23)ZFYVE1 (14q24.2) / UBTD1 (10q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZFYVE1   13180
Cards
Entrez_Gene (NCBI)ZFYVE1  53349  zinc finger FYVE-type containing 1
AliasesDFCP1; PPP1R172; SR3; TAFF1; 
ZNFN2A1
GeneCards (Weizmann)ZFYVE1
Ensembl hg19 (Hinxton)ENSG00000165861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165861 [Gene_View]  chr14:72969445-73027212 [Contig_View]  ZFYVE1 [Vega]
ICGC DataPortalENSG00000165861
TCGA cBioPortalZFYVE1
AceView (NCBI)ZFYVE1
Genatlas (Paris)ZFYVE1
WikiGenes53349
SOURCE (Princeton)ZFYVE1
Genetics Home Reference (NIH)ZFYVE1
Genomic and cartography
GoldenPath hg38 (UCSC)ZFYVE1  -     chr14:72969445-73027212 -  14q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFYVE1  -     14q24.2   [Description]    (hg19-Feb_2009)
EnsemblZFYVE1 - 14q24.2 [CytoView hg19]  ZFYVE1 - 14q24.2 [CytoView hg38]
Mapping of homologs : NCBIZFYVE1 [Mapview hg19]  ZFYVE1 [Mapview hg38]
OMIM605471   
Gene and transcription
Genbank (Entrez)AB046809 AF251025 AF311602 AF318319 AI073571
RefSeq transcript (Entrez)NM_001281734 NM_001281735 NM_021260 NM_178441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFYVE1
Cluster EST : UnigeneHs.335106 [ NCBI ]
CGAP (NCI)Hs.335106
Alternative Splicing GalleryENSG00000165861
Gene ExpressionZFYVE1 [ NCBI-GEO ]   ZFYVE1 [ EBI - ARRAY_EXPRESS ]   ZFYVE1 [ SEEK ]   ZFYVE1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFYVE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53349
GTEX Portal (Tissue expression)ZFYVE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBF4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBF4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBF4
Splice isoforms : SwissVarQ9HBF4
PhosPhoSitePlusQ9HBF4
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)   
Domains : Interpro (EBI)P-loop_NTPase    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)   
Domain families : Pfam (NCBI)pfam01363   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)ZFYVE1
DMDM Disease mutations53349
Blocks (Seattle)ZFYVE1
SuperfamilyQ9HBF4
Human Protein AtlasENSG00000165861
Peptide AtlasQ9HBF4
HPRD12017
IPIIPI00103874   IPI00186917   IPI01025293   IPI01025624   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBF4
IntAct (EBI)Q9HBF4
FunCoupENSG00000165861
BioGRIDZFYVE1
STRING (EMBL)ZFYVE1
ZODIACZFYVE1
Ontologies - Pathways
QuickGOQ9HBF4
Ontology : AmiGOpre-autophagosomal structure  protein binding  1-phosphatidylinositol binding  phosphatidylinositol-3,4,5-trisphosphate binding  autophagosome  endoplasmic reticulum  Golgi stack  zinc ion binding  cellular response to starvation  negative regulation of phosphatase activity  membrane  macroautophagy  phosphatidylinositol-3,4-bisphosphate binding  ER-mitochondrion membrane contact site  perinuclear region of cytoplasm  extrinsic component of omegasome membrane  
Ontology : EGO-EBIpre-autophagosomal structure  protein binding  1-phosphatidylinositol binding  phosphatidylinositol-3,4,5-trisphosphate binding  autophagosome  endoplasmic reticulum  Golgi stack  zinc ion binding  cellular response to starvation  negative regulation of phosphatase activity  membrane  macroautophagy  phosphatidylinositol-3,4-bisphosphate binding  ER-mitochondrion membrane contact site  perinuclear region of cytoplasm  extrinsic component of omegasome membrane  
NDEx NetworkZFYVE1
Atlas of Cancer Signalling NetworkZFYVE1
Wikipedia pathwaysZFYVE1
Orthology - Evolution
OrthoDB53349
GeneTree (enSembl)ENSG00000165861
Phylogenetic Trees/Animal Genes : TreeFamZFYVE1
HOVERGENQ9HBF4
HOGENOMQ9HBF4
Homologs : HomoloGeneZFYVE1
Homology/Alignments : Family Browser (UCSC)ZFYVE1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFYVE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFYVE1
dbVarZFYVE1
ClinVarZFYVE1
1000_GenomesZFYVE1 
Exome Variant ServerZFYVE1
ExAC (Exome Aggregation Consortium)ZFYVE1 (select the gene name)
Genetic variants : HAPMAP53349
Genomic Variants (DGV)ZFYVE1 [DGVbeta]
DECIPHERZFYVE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFYVE1 
Mutations
ICGC Data PortalZFYVE1 
TCGA Data PortalZFYVE1 
Broad Tumor PortalZFYVE1
OASIS PortalZFYVE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFYVE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFYVE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFYVE1
DgiDB (Drug Gene Interaction Database)ZFYVE1
DoCM (Curated mutations)ZFYVE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFYVE1 (select a term)
intoGenZFYVE1
Cancer3DZFYVE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605471   
Orphanet
MedgenZFYVE1
Genetic Testing Registry ZFYVE1
NextProtQ9HBF4 [Medical]
TSGene53349
GENETestsZFYVE1
Huge Navigator ZFYVE1 [HugePedia]
snp3D : Map Gene to Disease53349
BioCentury BCIQZFYVE1
ClinGenZFYVE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53349
Chemical/Pharm GKB GenePA37752
Clinical trialZFYVE1
Miscellaneous
canSAR (ICR)ZFYVE1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFYVE1
EVEXZFYVE1
GoPubMedZFYVE1
iHOPZFYVE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:02:19 CEST 2017

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