ZFYVE16 (zinc finger FYVE-type containing 16)

2014-11-01  

Identity

HGNC
LOCATION
5q14.1
LOCUSID
ALIAS
PPP1R69
FUSION GENES

Other Information

Locus ID:

NCBI: 9765
MIM: 608880
HGNC: 20756
Ensembl: ENSG00000039319

Variants:

dbSNP: 9765
ClinVar: 9765
TCGA: ENSG00000039319
COSMIC: ZFYVE16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000039319ENST00000338008Q7Z3T8
ENSG00000039319ENST00000505560Q7Z3T8
ENSG00000039319ENST00000507548H0Y8R0
ENSG00000039319ENST00000509558H0YAB1
ENSG00000039319ENST00000509562D6RC80
ENSG00000039319ENST00000510158Q7Z3T8
ENSG00000039319ENST00000513789H0YAA4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167750102006Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.32
172722732007Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.25
146139302004Endofin recruits TOM1 to endosomes.10
175705162007Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.7
198871072010EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.1
269441982016Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study.0

Citation

Dessen P

ZFYVE16 (zinc finger FYVE-type containing 16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75952/zfyve16