Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ZFYVE26 (zinc finger FYVE-type containing 26)

Identity

Alias_namesSPG15
spastic paraplegia 15 (complicated, autosomal recessive)
zinc finger, FYVE domain containing 26
Alias_symbol (synonym)KIAA0321
Other aliasFYVE-CENT
HGNC (Hugo) ZFYVE26
LocusID (NCBI) 23503
Atlas_Id 51489
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 67746520 and ends at 67816589 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP155 (5p13.2) / ZFYVE26 (14q24.1)TIA1 (2p13.3) / ZFYVE26 (14q24.1)ZFYVE26 (14q24.1) / MFSD2A (1p34.2)
ZFYVE26 (14q24.1) / RAD51B (14q24.1)NUP155 5p13.2 / ZFYVE26 14q24.1ZFYVE26 14q24.1 / RAD51B 14q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;14)(p13;q24) NUP155/ZFYVE26
ZFYVE26/RAD51B (14q24)


External links

Nomenclature
HGNC (Hugo)ZFYVE26   20761
Cards
Entrez_Gene (NCBI)ZFYVE26  23503  zinc finger FYVE-type containing 26
AliasesFYVE-CENT; SPG15
GeneCards (Weizmann)ZFYVE26
Ensembl hg19 (Hinxton)ENSG00000072121 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072121 [Gene_View]  ENSG00000072121 [Sequence]  chr14:67746520-67816589 [Contig_View]  ZFYVE26 [Vega]
ICGC DataPortalENSG00000072121
TCGA cBioPortalZFYVE26
AceView (NCBI)ZFYVE26
Genatlas (Paris)ZFYVE26
WikiGenes23503
SOURCE (Princeton)ZFYVE26
Genetics Home Reference (NIH)ZFYVE26
Genomic and cartography
GoldenPath hg38 (UCSC)ZFYVE26  -     chr14:67746520-67816589 -  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFYVE26  -     14q24.1   [Description]    (hg19-Feb_2009)
ZFYVE26 - 14q24.1 [CytoView hg19]  ZFYVE26 - 14q24.1 [CytoView hg38]
Mapping of homologs : NCBIZFYVE26 [Mapview hg19]  ZFYVE26 [Mapview hg38]
OMIM270700   612012   
Gene and transcription
Genbank (Entrez)AB002319 AB425197 AK024743 AK304428 AK308233
RefSeq transcript (Entrez)NM_015346
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFYVE26
Cluster EST : UnigeneHs.98041 [ NCBI ]
CGAP (NCI)Hs.98041
Alternative Splicing GalleryENSG00000072121
Gene ExpressionZFYVE26 [ NCBI-GEO ]   ZFYVE26 [ EBI - ARRAY_EXPRESS ]   ZFYVE26 [ SEEK ]   ZFYVE26 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFYVE26 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23503
GTEX Portal (Tissue expression)ZFYVE26
Human Protein AtlasENSG00000072121-ZFYVE26 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68DK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68DK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68DK2
Splice isoforms : SwissVarQ68DK2
PhosPhoSitePlusQ68DK2
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)   
Domains : Interpro (EBI)ZFYVE26    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)   
Domain families : Pfam (NCBI)pfam01363   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)ZFYVE26
DMDM Disease mutations23503
Blocks (Seattle)ZFYVE26
SuperfamilyQ68DK2
Human Protein Atlas [tissue]ENSG00000072121-ZFYVE26 [tissue]
Peptide AtlasQ68DK2
HPRD15734
IPIIPI00879253   IPI00470896   IPI00796956   IPI01010491   IPI00985431   IPI01025947   
Protein Interaction databases
DIP (DOE-UCLA)Q68DK2
IntAct (EBI)Q68DK2
FunCoupENSG00000072121
BioGRIDZFYVE26
STRING (EMBL)ZFYVE26
ZODIACZFYVE26
Ontologies - Pathways
QuickGOQ68DK2
Ontology : AmiGOmitotic cytokinesis  double-strand break repair via homologous recombination  protein binding  lysosomal membrane  centrosome  centrosome  midbody  midbody  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  regulation of cytokinesis  regulation of cytokinesis  metal ion binding  
Ontology : EGO-EBImitotic cytokinesis  double-strand break repair via homologous recombination  protein binding  lysosomal membrane  centrosome  centrosome  midbody  midbody  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  regulation of cytokinesis  regulation of cytokinesis  metal ion binding  
NDEx NetworkZFYVE26
Atlas of Cancer Signalling NetworkZFYVE26
Wikipedia pathwaysZFYVE26
Orthology - Evolution
OrthoDB23503
GeneTree (enSembl)ENSG00000072121
Phylogenetic Trees/Animal Genes : TreeFamZFYVE26
HOGENOMQ68DK2
Homologs : HomoloGeneZFYVE26
Homology/Alignments : Family Browser (UCSC)ZFYVE26
Gene fusions - Rearrangements
Fusion : MitelmanNUP155/ZFYVE26 [5p13.2/14q24.1]  [t(5;14)(p13;q24)]  
Fusion : MitelmanZFYVE26/RAD51B [14q24.1/14q24.1]  [t(14;14)(q24;q24)]  
Fusion PortalNUP155 5p13.2 ZFYVE26 14q24.1 BRCA
Fusion PortalZFYVE26 14q24.1 RAD51B 14q24.1 BRCA
Fusion : QuiverZFYVE26
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFYVE26 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFYVE26
dbVarZFYVE26
ClinVarZFYVE26
1000_GenomesZFYVE26 
Exome Variant ServerZFYVE26
ExAC (Exome Aggregation Consortium)ENSG00000072121
GNOMAD BrowserENSG00000072121
Varsome BrowserZFYVE26
Genetic variants : HAPMAP23503
Genomic Variants (DGV)ZFYVE26 [DGVbeta]
DECIPHERZFYVE26 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFYVE26 
Mutations
ICGC Data PortalZFYVE26 
TCGA Data PortalZFYVE26 
Broad Tumor PortalZFYVE26
OASIS PortalZFYVE26 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFYVE26  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFYVE26
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ZFYVE26
DgiDB (Drug Gene Interaction Database)ZFYVE26
DoCM (Curated mutations)ZFYVE26 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFYVE26 (select a term)
intoGenZFYVE26
Cancer3DZFYVE26(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM270700    612012   
Orphanet14707   
DisGeNETZFYVE26
MedgenZFYVE26
Genetic Testing Registry ZFYVE26
NextProtQ68DK2 [Medical]
TSGene23503
GENETestsZFYVE26
Target ValidationZFYVE26
Huge Navigator ZFYVE26 [HugePedia]
snp3D : Map Gene to Disease23503
BioCentury BCIQZFYVE26
ClinGenZFYVE26
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23503
Chemical/Pharm GKB GenePA134904455
Clinical trialZFYVE26
Miscellaneous
canSAR (ICR)ZFYVE26 (select the gene name)
DataMed IndexZFYVE26
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFYVE26
EVEXZFYVE26
GoPubMedZFYVE26
iHOPZFYVE26
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu May 2 13:17:54 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.