Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZFYVE27 (zinc finger FYVE-type containing 27)

Identity

Alias (NCBI)PROTRUDIN
SPG33
HGNC (Hugo) ZFYVE27
HGNC Alias symbFLJ32919
SPG33
HGNC Alias nameprotrudin
HGNC Previous namezinc finger, FYVE domain containing 27
LocusID (NCBI) 118813
Atlas_Id 75954
Location 10q24.2  [Link to chromosome band 10q24]
Location_base_pair Starts at 97737121 and ends at 97760907 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SAMD11 (1p36.33) / ZFYVE27 (10q24.2)ZFYVE27 (10q24.2) / LOC100507412 (-)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ZFYVE27   26559
Cards
Entrez_Gene (NCBI)ZFYVE27  118813  zinc finger FYVE-type containing 27
AliasesPROTRUDIN; SPG33
GeneCards (Weizmann)ZFYVE27
Ensembl hg19 (Hinxton)ENSG00000155256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155256 [Gene_View]  ENSG00000155256 [Sequence]  chr10:97737121-97760907 [Contig_View]  ZFYVE27 [Vega]
ICGC DataPortalENSG00000155256
TCGA cBioPortalZFYVE27
AceView (NCBI)ZFYVE27
Genatlas (Paris)ZFYVE27
WikiGenes118813
SOURCE (Princeton)ZFYVE27
Genetics Home Reference (NIH)ZFYVE27
Genomic and cartography
GoldenPath hg38 (UCSC)ZFYVE27  -     chr10:97737121-97760907 +  10q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFYVE27  -     10q24.2   [Description]    (hg19-Feb_2009)
GoldenPathZFYVE27 - 10q24.2 [CytoView hg19]  ZFYVE27 - 10q24.2 [CytoView hg38]
ImmunoBaseENSG00000155256
genome Data Viewer NCBIZFYVE27 [Mapview hg19]  
OMIM610243   610244   
Gene and transcription
Genbank (Entrez)AK057481 AK074876 AK097945 AK296295 AK296588
RefSeq transcript (Entrez)NM_001002261 NM_001002262 NM_001174119 NM_001174120 NM_001174121 NM_001174122 NM_144588
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFYVE27
Alternative Splicing GalleryENSG00000155256
Gene ExpressionZFYVE27 [ NCBI-GEO ]   ZFYVE27 [ EBI - ARRAY_EXPRESS ]   ZFYVE27 [ SEEK ]   ZFYVE27 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFYVE27 [ Firebrowse - Broad ]
GenevisibleExpression of ZFYVE27 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)118813
GTEX Portal (Tissue expression)ZFYVE27
Human Protein AtlasENSG00000155256-ZFYVE27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T4F4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T4F4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T4F4
Splice isoforms : SwissVarQ5T4F4
PhosPhoSitePlusQ5T4F4
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)   
Domains : Interpro (EBI)Protrudin    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)   
Domain families : Pfam (NCBI)pfam01363   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)ZFYVE27
DMDM Disease mutations118813
Blocks (Seattle)ZFYVE27
PDB (RSDB)1X4U   
PDB Europe1X4U   
PDB (PDBSum)1X4U   
PDB (IMB)1X4U   
Structural Biology KnowledgeBase1X4U   
SCOP (Structural Classification of Proteins)1X4U   
CATH (Classification of proteins structures)1X4U   
SuperfamilyQ5T4F4
Human Protein Atlas [tissue]ENSG00000155256-ZFYVE27 [tissue]
Peptide AtlasQ5T4F4
HPRD15735
IPIIPI00332094   IPI00301446   IPI00434983   IPI00166179   IPI00927269   IPI00956753   IPI00956653   IPI00922790   
Protein Interaction databases
DIP (DOE-UCLA)Q5T4F4
IntAct (EBI)Q5T4F4
FunCoupENSG00000155256
BioGRIDZFYVE27
STRING (EMBL)ZFYVE27
ZODIACZFYVE27
Ontologies - Pathways
QuickGOQ5T4F4
Ontology : AmiGOprotein binding  nucleoplasm  endoplasmic reticulum  cytosol  vesicle-mediated transport  vesicle-mediated transport  integral component of endoplasmic reticulum membrane  axon  dendrite  neuron projection development  neuron projection development  growth cone membrane  growth cone membrane  intracellular membrane-bounded organelle  protein self-association  protein self-association  positive regulation of axon extension  positive regulation of axon extension  metal ion binding  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  recycling endosome membrane  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network formation  endoplasmic reticulum tubular network formation  protein localization to plasma membrane  protein localization to plasma membrane  
Ontology : EGO-EBIprotein binding  nucleoplasm  endoplasmic reticulum  cytosol  vesicle-mediated transport  vesicle-mediated transport  integral component of endoplasmic reticulum membrane  axon  dendrite  neuron projection development  neuron projection development  growth cone membrane  growth cone membrane  intracellular membrane-bounded organelle  protein self-association  protein self-association  positive regulation of axon extension  positive regulation of axon extension  metal ion binding  neurotrophin TRK receptor signaling pathway  neurotrophin TRK receptor signaling pathway  recycling endosome membrane  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network formation  endoplasmic reticulum tubular network formation  protein localization to plasma membrane  protein localization to plasma membrane  
NDEx NetworkZFYVE27
Atlas of Cancer Signalling NetworkZFYVE27
Wikipedia pathwaysZFYVE27
Orthology - Evolution
OrthoDB118813
GeneTree (enSembl)ENSG00000155256
Phylogenetic Trees/Animal Genes : TreeFamZFYVE27
HOGENOMQ5T4F4
Homologs : HomoloGeneZFYVE27
Homology/Alignments : Family Browser (UCSC)ZFYVE27
Gene fusions - Rearrangements
Fusion : QuiverZFYVE27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFYVE27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFYVE27
dbVarZFYVE27
ClinVarZFYVE27
1000_GenomesZFYVE27 
Exome Variant ServerZFYVE27
GNOMAD BrowserENSG00000155256
Varsome BrowserZFYVE27
Genetic variants : HAPMAP118813
Genomic Variants (DGV)ZFYVE27 [DGVbeta]
DECIPHERZFYVE27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFYVE27 
Mutations
ICGC Data PortalZFYVE27 
TCGA Data PortalZFYVE27 
Broad Tumor PortalZFYVE27
OASIS PortalZFYVE27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFYVE27  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZFYVE27
Mutations and Diseases : HGMDZFYVE27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFYVE27
DgiDB (Drug Gene Interaction Database)ZFYVE27
DoCM (Curated mutations)ZFYVE27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFYVE27 (select a term)
intoGenZFYVE27
Cancer3DZFYVE27(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610243    610244   
Orphanet
DisGeNETZFYVE27
MedgenZFYVE27
Genetic Testing Registry ZFYVE27
NextProtQ5T4F4 [Medical]
TSGene118813
GENETestsZFYVE27
Target ValidationZFYVE27
Huge Navigator ZFYVE27 [HugePedia]
snp3D : Map Gene to Disease118813
BioCentury BCIQZFYVE27
ClinGenZFYVE27
Clinical trials, drugs, therapy
Protein Interactions : CTD118813
Pharm GKB GenePA134863310
Clinical trialZFYVE27
Miscellaneous
canSAR (ICR)ZFYVE27 (select the gene name)
HarmonizomeZFYVE27
DataMed IndexZFYVE27
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFYVE27
EVEXZFYVE27
GoPubMedZFYVE27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:36:07 CEST 2020
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