ZFYVE9 (zinc finger FYVE-type containing 9)

2003-06-01 Affiliation

Identity

HGNC

ZFYVE9

LOCATION

1p32.3

LOCUSID

9372

ALIAS

MADHIP,NSP,PPP1R173,SARA,SMADIP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9372
MIM: 603755
HGNC: 6775
Ensembl: ENSG00000157077

Variants:

dbSNP: 9372
ClinVar: 9372
TCGA: ENSG00000157077
COSMIC: ZFYVE9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157077	ENST00000287727	O95405
ENSG00000157077	ENST00000357206	O95405
ENSG00000157077	ENST00000371591	O95405

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
TGF-beta signaling pathway	KEGG	hsa04350
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by TGF-beta Receptor Complex in Cancer	REACTOME	R-HSA-3304351
Loss of Function of SMAD2/3 in Cancer	REACTOME	R-HSA-3304349
SMAD2/3 Phosphorylation Motif Mutants in Cancer	REACTOME	R-HSA-3304356
SMAD2/3 MH2 Domain Mutants in Cancer	REACTOME	R-HSA-3315487
Loss of Function of TGFBR1 in Cancer	REACTOME	R-HSA-3656534
TGFBR1 KD Mutants in Cancer	REACTOME	R-HSA-3656532
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling activates SMADs	REACTOME	R-HSA-2173789
Downregulation of TGF-beta receptor signaling	REACTOME	R-HSA-2173788

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17693260	2007	SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.	80
15613484	2005	The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells.	46
11877415	2002	Early endosomal regulation of Smad-dependent signaling in endothelial cells.	42
17356069	2007	Endofin acts as a Smad anchor for receptor activation in BMP signaling.	31
12432064	2002	SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.	27
19620243	2009	Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype.	17
23222715	2013	SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.	14
22819827	2012	SARA is dispensable for functional TGF-β signaling.	13
15231848	2004	Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.	9
25614622	2015	Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.	9

Citation

Dessen P

ZFYVE9 (zinc finger FYVE-type containing 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41233/zfyve9