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ZFYVE9 (zinc finger FYVE-type containing 9)

Identity

Alias (NCBI)MADHIP
NSP
PPP1R173
SARA
SMADIP
HGNC (Hugo) ZFYVE9
HGNC Alias symbSMADIP
SARA
PPP1R173
HGNC Alias nameprotein phosphatase 1, regulatory subunit 173
HGNC Previous nameMADHIP
HGNC Previous nameMAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor
 zinc finger, FYVE domain containing 9
LocusID (NCBI) 9372
Atlas_Id 41233
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 52142089 and ends at 52346686 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FOXJ3 (1p34.2) / ZFYVE9 (1p32.3)KIRREL (1q23.1) / ZFYVE9 (1p32.3)ZFYVE9 (1p32.3) / CGA (6q14.3)
ZFYVE9 (1p32.3) / SPAG16 (2q34)ZFYVE9 (1p32.3) / USP33 (1p31.1)FOXJ3 1p34.2 / ZFYVE9 1p32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ZFYVE9   6775
Cards
Entrez_Gene (NCBI)ZFYVE9    zinc finger FYVE-type containing 9
AliasesMADHIP; NSP; PPP1R173; SARA; 
SMADIP
GeneCards (Weizmann)ZFYVE9
Ensembl hg19 (Hinxton)ENSG00000157077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157077 [Gene_View]  ENSG00000157077 [Sequence]  chr1:52142089-52346686 [Contig_View]  ZFYVE9 [Vega]
ICGC DataPortalENSG00000157077
TCGA cBioPortalZFYVE9
AceView (NCBI)ZFYVE9
Genatlas (Paris)ZFYVE9
SOURCE (Princeton)ZFYVE9
Genetics Home Reference (NIH)ZFYVE9
Genomic and cartography
GoldenPath hg38 (UCSC)ZFYVE9  -     chr1:52142089-52346686 +  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFYVE9  -     1p32.3   [Description]    (hg19-Feb_2009)
GoldenPathZFYVE9 - 1p32.3 [CytoView hg19]  ZFYVE9 - 1p32.3 [CytoView hg38]
ImmunoBaseENSG00000157077
Genome Data Viewer NCBIZFYVE9 [Mapview hg19]  
OMIM603755   
Gene and transcription
Genbank (Entrez)AB209125 AF104304 AF130419 AF130420 BC032680
RefSeq transcript (Entrez)NM_004799 NM_007323 NM_007324
Consensus coding sequences : CCDS (NCBI)ZFYVE9
Gene ExpressionZFYVE9 [ NCBI-GEO ]   ZFYVE9 [ EBI - ARRAY_EXPRESS ]   ZFYVE9 [ SEEK ]   ZFYVE9 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFYVE9 [ Firebrowse - Broad ]
GenevisibleExpression of ZFYVE9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9372
GTEX Portal (Tissue expression)ZFYVE9
Human Protein AtlasENSG00000157077-ZFYVE9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95405
PhosPhoSitePlusO95405
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DUF3480    SARA/endofin    SARA_Smad-bd    SARA_Smad-bd_sf    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)DUF3480 (PF11979)    FYVE (PF01363)    SARA (PF11409)   
Domain families : Pfam (NCBI)pfam11979    pfam01363    pfam11409   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)ZFYVE9
PDB (RSDB)1DEV    1MK2    4BKW    5MJY   
PDB Europe1DEV    1MK2    4BKW    5MJY   
PDB (PDBSum)1DEV    1MK2    4BKW    5MJY   
PDB (IMB)1DEV    1MK2    4BKW    5MJY   
Structural Biology KnowledgeBase1DEV    1MK2    4BKW    5MJY   
SCOP (Structural Classification of Proteins)1DEV    1MK2    4BKW    5MJY   
CATH (Classification of proteins structures)1DEV    1MK2    4BKW    5MJY   
SuperfamilyO95405
AlphaFold pdb e-kbO95405   
Human Protein Atlas [tissue]ENSG00000157077-ZFYVE9 [tissue]
HPRD04782
Protein Interaction databases
DIP (DOE-UCLA)O95405
IntAct (EBI)O95405
BioGRIDZFYVE9
STRING (EMBL)ZFYVE9
ZODIACZFYVE9
Ontologies - Pathways
QuickGOO95405
Ontology : AmiGOprotein binding  1-phosphatidylinositol binding  early endosome  cytosol  endocytosis  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  endosomal transport  protein domain specific binding  early endosome membrane  early endosome membrane  early endosome membrane  protein-containing complex  intracellular membrane-bounded organelle  metal ion binding  
Ontology : EGO-EBIprotein binding  1-phosphatidylinositol binding  early endosome  cytosol  endocytosis  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  endosomal transport  protein domain specific binding  early endosome membrane  early endosome membrane  early endosome membrane  protein-containing complex  intracellular membrane-bounded organelle  metal ion binding  
Pathways : BIOCARTATGF beta signaling pathway [Genes]   
Pathways : KEGGEndocytosis    TGF-beta signaling pathway   
NDEx NetworkZFYVE9
Atlas of Cancer Signalling NetworkZFYVE9
Wikipedia pathwaysZFYVE9
Orthology - Evolution
OrthoDB9372
GeneTree (enSembl)ENSG00000157077
Phylogenetic Trees/Animal Genes : TreeFamZFYVE9
Homologs : HomoloGeneZFYVE9
Homology/Alignments : Family Browser (UCSC)ZFYVE9
Gene fusions - Rearrangements
Fusion : MitelmanFOXJ3/ZFYVE9 [1p34.2/1p32.3]  
Fusion : MitelmanZFYVE9/CGA [1p32.3/6q14.3]  
Fusion : QuiverZFYVE9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFYVE9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFYVE9
dbVarZFYVE9
ClinVarZFYVE9
MonarchZFYVE9
1000_GenomesZFYVE9 
Exome Variant ServerZFYVE9
GNOMAD BrowserENSG00000157077
Varsome BrowserZFYVE9
ACMGZFYVE9 variants
VarityO95405
Genomic Variants (DGV)ZFYVE9 [DGVbeta]
DECIPHERZFYVE9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFYVE9 
Mutations
ICGC Data PortalZFYVE9 
TCGA Data PortalZFYVE9 
Broad Tumor PortalZFYVE9
OASIS PortalZFYVE9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFYVE9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZFYVE9
Mutations and Diseases : HGMDZFYVE9
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZFYVE9
DgiDB (Drug Gene Interaction Database)ZFYVE9
DoCM (Curated mutations)ZFYVE9
CIViC (Clinical Interpretations of Variants in Cancer)ZFYVE9
Cancer3DZFYVE9
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603755   
Orphanet
DisGeNETZFYVE9
MedgenZFYVE9
Genetic Testing Registry ZFYVE9
NextProtO95405 [Medical]
GENETestsZFYVE9
Target ValidationZFYVE9
Huge Navigator ZFYVE9 [HugePedia]
ClinGenZFYVE9
Clinical trials, drugs, therapy
MyCancerGenomeZFYVE9
Protein Interactions : CTDZFYVE9
Pharm GKB GenePA30532
PharosO95405
Clinical trialZFYVE9
Miscellaneous
canSAR (ICR)ZFYVE9
HarmonizomeZFYVE9
DataMed IndexZFYVE9
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZFYVE9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:39:00 CEST 2021

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