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ZFYVE9 (zinc finger FYVE-type containing 9)

Identity

Alias_namesregulatory subunit 173
MADHIP
Alias_symbol (synonym)SMADIP
SARA
PPP1R173
Other aliasNSP
HGNC (Hugo) ZFYVE9
LocusID (NCBI) 9372
Atlas_Id 41233
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 52142094 and ends at 52346686 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FOXJ3 (1p34.2) / ZFYVE9 (1p32.3)KIRREL (1q23.1) / ZFYVE9 (1p32.3)ZFYVE9 (1p32.3) / CGA (6q14.3)
ZFYVE9 (1p32.3) / SPAG16 (2q34)ZFYVE9 (1p32.3) / USP33 (1p31.1)FOXJ3 1p34.2 / ZFYVE9 1p32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)ZFYVE9   6775
Cards
Entrez_Gene (NCBI)ZFYVE9  9372  zinc finger FYVE-type containing 9
AliasesMADHIP; NSP; PPP1R173; SARA; 
SMADIP
GeneCards (Weizmann)ZFYVE9
Ensembl hg19 (Hinxton)ENSG00000157077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157077 [Gene_View]  chr1:52142094-52346686 [Contig_View]  ZFYVE9 [Vega]
ICGC DataPortalENSG00000157077
TCGA cBioPortalZFYVE9
AceView (NCBI)ZFYVE9
Genatlas (Paris)ZFYVE9
WikiGenes9372
SOURCE (Princeton)ZFYVE9
Genetics Home Reference (NIH)ZFYVE9
Genomic and cartography
GoldenPath hg38 (UCSC)ZFYVE9  -     chr1:52142094-52346686 +  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFYVE9  -     1p32.3   [Description]    (hg19-Feb_2009)
EnsemblZFYVE9 - 1p32.3 [CytoView hg19]  ZFYVE9 - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBIZFYVE9 [Mapview hg19]  ZFYVE9 [Mapview hg38]
OMIM603755   
Gene and transcription
Genbank (Entrez)AB209125 AF104304 AF130419 AF130420 BC032680
RefSeq transcript (Entrez)NM_004799 NM_007323 NM_007324
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFYVE9
Cluster EST : UnigeneHs.532345 [ NCBI ]
CGAP (NCI)Hs.532345
Alternative Splicing GalleryENSG00000157077
Gene ExpressionZFYVE9 [ NCBI-GEO ]   ZFYVE9 [ EBI - ARRAY_EXPRESS ]   ZFYVE9 [ SEEK ]   ZFYVE9 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFYVE9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9372
GTEX Portal (Tissue expression)ZFYVE9
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95405
Splice isoforms : SwissVarO95405
PhosPhoSitePlusO95405
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DUF3480    SARA_Smad-bd    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)DUF3480 (PF11979)    FYVE (PF01363)    SARA (PF11409)   
Domain families : Pfam (NCBI)pfam11979    pfam01363    pfam11409   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)ZFYVE9
DMDM Disease mutations9372
Blocks (Seattle)ZFYVE9
PDB (SRS)1DEV    1MK2    4BKW   
PDB (PDBSum)1DEV    1MK2    4BKW   
PDB (IMB)1DEV    1MK2    4BKW   
PDB (RSDB)1DEV    1MK2    4BKW   
Structural Biology KnowledgeBase1DEV    1MK2    4BKW   
SCOP (Structural Classification of Proteins)1DEV    1MK2    4BKW   
CATH (Classification of proteins structures)1DEV    1MK2    4BKW   
SuperfamilyO95405
Human Protein AtlasENSG00000157077
Peptide AtlasO95405
HPRD04782
IPIIPI00030648   IPI00480079   IPI00026338   
Protein Interaction databases
DIP (DOE-UCLA)O95405
IntAct (EBI)O95405
FunCoupENSG00000157077
BioGRIDZFYVE9
STRING (EMBL)ZFYVE9
ZODIACZFYVE9
Ontologies - Pathways
QuickGOO95405
Ontology : AmiGOprotein binding  1-phosphatidylinositol binding  early endosome  cytosol  proteolysis  endocytosis  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  SMAD protein import into nucleus  serine-type peptidase activity  protein domain specific binding  early endosome membrane  early endosome membrane  intracellular membrane-bounded organelle  protein complex  metal ion binding  
Ontology : EGO-EBIprotein binding  1-phosphatidylinositol binding  early endosome  cytosol  proteolysis  endocytosis  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  SMAD protein import into nucleus  serine-type peptidase activity  protein domain specific binding  early endosome membrane  early endosome membrane  intracellular membrane-bounded organelle  protein complex  metal ion binding  
Pathways : BIOCARTATGF beta signaling pathway [Genes]   
Pathways : KEGGEndocytosis    TGF-beta signaling pathway   
NDEx NetworkZFYVE9
Atlas of Cancer Signalling NetworkZFYVE9
Wikipedia pathwaysZFYVE9
Orthology - Evolution
OrthoDB9372
GeneTree (enSembl)ENSG00000157077
Phylogenetic Trees/Animal Genes : TreeFamZFYVE9
HOVERGENO95405
HOGENOMO95405
Homologs : HomoloGeneZFYVE9
Homology/Alignments : Family Browser (UCSC)ZFYVE9
Gene fusions - Rearrangements
Fusion : MitelmanFOXJ3/ZFYVE9 [1p34.2/1p32.3]  [t(1;1)(p32;p34)]  
Fusion : MitelmanZFYVE9/CGA [1p32.3/6q14.3]  [t(1;6)(p32;q14)]  
Fusion: TCGAFOXJ3 1p34.2 ZFYVE9 1p32.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFYVE9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFYVE9
dbVarZFYVE9
ClinVarZFYVE9
1000_GenomesZFYVE9 
Exome Variant ServerZFYVE9
ExAC (Exome Aggregation Consortium)ZFYVE9 (select the gene name)
Genetic variants : HAPMAP9372
Genomic Variants (DGV)ZFYVE9 [DGVbeta]
DECIPHERZFYVE9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFYVE9 
Mutations
ICGC Data PortalZFYVE9 
TCGA Data PortalZFYVE9 
Broad Tumor PortalZFYVE9
OASIS PortalZFYVE9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFYVE9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFYVE9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFYVE9
DgiDB (Drug Gene Interaction Database)ZFYVE9
DoCM (Curated mutations)ZFYVE9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFYVE9 (select a term)
intoGenZFYVE9
Cancer3DZFYVE9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603755   
Orphanet
MedgenZFYVE9
Genetic Testing Registry ZFYVE9
NextProtO95405 [Medical]
TSGene9372
GENETestsZFYVE9
Target ValidationZFYVE9
Huge Navigator ZFYVE9 [HugePedia]
snp3D : Map Gene to Disease9372
BioCentury BCIQZFYVE9
ClinGenZFYVE9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9372
Chemical/Pharm GKB GenePA30532
Clinical trialZFYVE9
Miscellaneous
canSAR (ICR)ZFYVE9 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFYVE9
EVEXZFYVE9
GoPubMedZFYVE9
iHOPZFYVE9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:19:20 CEST 2017

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