Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZHX2 (zinc fingers and homeoboxes 2)

Identity

Alias_nameszinc-fingers and homeoboxes 2
Alias_symbol (synonym)KIAA0854
Other aliasAFR1
RAF
HGNC (Hugo) ZHX2
LocusID (NCBI) 22882
Atlas_Id 47603
Location 8q24.13  [Link to chromosome band 8q24]
Location_base_pair Starts at 123793901 and ends at 123986755 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAB14 (9q33.2) / ZHX2 (8q24.13)STK3 (8q22.2) / ZHX2 (8q24.13)VAV3 (1p13.3) / ZHX2 (8q24.13)
ZHX2 (8q24.13) / DDX52 (17q12)ZHX2 (8q24.13) / LOC401320 (7p14.3)ZHX2 (8q24.13) / SMARCC1 (3p21.31)
ZHX2 (8q24.13) / ZHX2 (8q24.13)STK3 8q22.2 / ZHX2 8q24.13VAV3 1p13.3 / ZHX2 8q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZHX2   18513
Cards
Entrez_Gene (NCBI)ZHX2  22882  zinc fingers and homeoboxes 2
AliasesAFR1; RAF
GeneCards (Weizmann)ZHX2
Ensembl hg19 (Hinxton)ENSG00000178764 [Gene_View]  chr8:123793901-123986755 [Contig_View]  ZHX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178764 [Gene_View]  chr8:123793901-123986755 [Contig_View]  ZHX2 [Vega]
ICGC DataPortalENSG00000178764
TCGA cBioPortalZHX2
AceView (NCBI)ZHX2
Genatlas (Paris)ZHX2
WikiGenes22882
SOURCE (Princeton)ZHX2
Genetics Home Reference (NIH)ZHX2
Genomic and cartography
GoldenPath hg19 (UCSC)ZHX2  -     chr8:123793901-123986755 +  8q24.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZHX2  -     8q24.13   [Description]    (hg38-Dec_2013)
EnsemblZHX2 - 8q24.13 [CytoView hg19]  ZHX2 - 8q24.13 [CytoView hg38]
Mapping of homologs : NCBIZHX2 [Mapview hg19]  ZHX2 [Mapview hg38]
OMIM609185   
Gene and transcription
Genbank (Entrez)AB020661 AB083653 AF075099 AI334237 BC042145
RefSeq transcript (Entrez)NM_014943
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)ZHX2
Cluster EST : UnigeneHs.658443 [ NCBI ]
CGAP (NCI)Hs.658443
Alternative Splicing GalleryENSG00000178764
Gene ExpressionZHX2 [ NCBI-GEO ]   ZHX2 [ EBI - ARRAY_EXPRESS ]   ZHX2 [ SEEK ]   ZHX2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZHX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22882
GTEX Portal (Tissue expression)ZHX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6X8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6X8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6X8
Splice isoforms : SwissVarQ9Y6X8
PhosPhoSitePlusQ9Y6X8
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like    Znf_C2H2    Znf_C2H2-like   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZHX2
DMDM Disease mutations22882
Blocks (Seattle)ZHX2
PDB (SRS)2DMP    3NAU   
PDB (PDBSum)2DMP    3NAU   
PDB (IMB)2DMP    3NAU   
PDB (RSDB)2DMP    3NAU   
Structural Biology KnowledgeBase2DMP    3NAU   
SCOP (Structural Classification of Proteins)2DMP    3NAU   
CATH (Classification of proteins structures)2DMP    3NAU   
SuperfamilyQ9Y6X8
Human Protein AtlasENSG00000178764
Peptide AtlasQ9Y6X8
HPRD16458
IPIIPI00007256   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6X8
IntAct (EBI)Q9Y6X8
FunCoupENSG00000178764
BioGRIDZHX2
STRING (EMBL)ZHX2
ZODIACZHX2
Ontologies - Pathways
QuickGOQ9Y6X8
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  transcription, DNA-templated  mRNA catabolic process  somatic stem cell population maintenance  identical protein binding  protein homodimerization activity  negative regulation of neuron differentiation  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  plasma membrane  transcription, DNA-templated  mRNA catabolic process  somatic stem cell population maintenance  identical protein binding  protein homodimerization activity  negative regulation of neuron differentiation  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  
NDEx NetworkZHX2
Atlas of Cancer Signalling NetworkZHX2
Wikipedia pathwaysZHX2
Orthology - Evolution
OrthoDB22882
GeneTree (enSembl)ENSG00000178764
Phylogenetic Trees/Animal Genes : TreeFamZHX2
HOVERGENQ9Y6X8
HOGENOMQ9Y6X8
Homologs : HomoloGeneZHX2
Homology/Alignments : Family Browser (UCSC)ZHX2
Gene fusions - Rearrangements
Fusion : MitelmanSTK3/ZHX2 [8q22.2/8q24.13]  [t(8;8)(q22;q24)]  
Fusion : MitelmanVAV3/ZHX2 [1p13.3/8q24.13]  [t(1;8)(p13;q24)]  
Fusion: TCGASTK3 8q22.2 ZHX2 8q24.13 LUAD
Fusion: TCGAVAV3 1p13.3 ZHX2 8q24.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZHX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZHX2
dbVarZHX2
ClinVarZHX2
1000_GenomesZHX2 
Exome Variant ServerZHX2
ExAC (Exome Aggregation Consortium)ZHX2 (select the gene name)
Genetic variants : HAPMAP22882
Genomic Variants (DGV)ZHX2 [DGVbeta]
DECIPHER (Syndromes)8:123793901-123986755  ENSG00000178764
CONAN: Copy Number AnalysisZHX2 
Mutations
ICGC Data PortalZHX2 
TCGA Data PortalZHX2 
Broad Tumor PortalZHX2
OASIS PortalZHX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZHX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZHX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZHX2
DgiDB (Drug Gene Interaction Database)ZHX2
DoCM (Curated mutations)ZHX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZHX2 (select a term)
intoGenZHX2
Cancer3DZHX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609185   
Orphanet
MedgenZHX2
Genetic Testing Registry ZHX2
NextProtQ9Y6X8 [Medical]
TSGene22882
GENETestsZHX2
Huge Navigator ZHX2 [HugePedia]
snp3D : Map Gene to Disease22882
BioCentury BCIQZHX2
ClinGenZHX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22882
Chemical/Pharm GKB GenePA128394591
Clinical trialZHX2
Miscellaneous
canSAR (ICR)ZHX2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZHX2
EVEXZHX2
GoPubMedZHX2
iHOPZHX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:34:52 CET 2017

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