ZIC1 (Zic family member 1)

2003-06-01  

Identity

HGNC
LOCATION
3q24
LOCUSID
ALIAS
BAIDCS,CRS6,ZIC,ZNF201
FUSION GENES

Other Information

Locus ID:

NCBI: 7545
MIM: 600470
HGNC: 12872
Ensembl: ENSG00000152977

Variants:

dbSNP: 7545
ClinVar: 7545
TCGA: ENSG00000152977
COSMIC: ZIC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152977ENST00000282928Q15915
ENSG00000152977ENST00000488404H7C5D8

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185155502008Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif.55
153380082004Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.54
127839902003The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.31
237748002013Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers.24
191359842009ZIC1 is downregulated through promoter hypermethylation in gastric cancer.22
213472332011ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.21
227997642012ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer.20
201996892010Expression of ZIC family genes in meningiomas and other brain tumors.19
207135272010ZIC1 overexpression is oncogenic in liposarcoma.18
246844572014ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.17

Citation

Dessen P

ZIC1 (Zic family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42867/zic1