Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZIC2 (Zic family member 2)

Identity

Alias_namesZic family member 2 (odd-paired Drosophila homolog)
Zic family member 2 (odd-paired homolog, Drosophila)
Alias_symbol (synonym)HPE5
Other alias
HGNC (Hugo) ZIC2
LocusID (NCBI) 7546
Atlas_Id 51523
Location 13q32.3  [Link to chromosome band 13q32]
Location_base_pair Starts at 99981756 and ends at 99986773 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ZIC2   12873
Cards
Entrez_Gene (NCBI)ZIC2  7546  Zic family member 2
AliasesHPE5
GeneCards (Weizmann)ZIC2
Ensembl hg19 (Hinxton)ENSG00000043355 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000043355 [Gene_View]  chr13:99981756-99986773 [Contig_View]  ZIC2 [Vega]
ICGC DataPortalENSG00000043355
TCGA cBioPortalZIC2
AceView (NCBI)ZIC2
Genatlas (Paris)ZIC2
WikiGenes7546
SOURCE (Princeton)ZIC2
Genetics Home Reference (NIH)ZIC2
Genomic and cartography
GoldenPath hg38 (UCSC)ZIC2  -     chr13:99981756-99986773 +  13q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZIC2  -     13q32.3   [Description]    (hg19-Feb_2009)
EnsemblZIC2 - 13q32.3 [CytoView hg19]  ZIC2 - 13q32.3 [CytoView hg38]
Mapping of homologs : NCBIZIC2 [Mapview hg19]  ZIC2 [Mapview hg38]
OMIM603073   609637   
Gene and transcription
Genbank (Entrez)AA491603 AF104902 AF188733 AF193855 AF339806
RefSeq transcript (Entrez)NM_007129
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZIC2
Cluster EST : UnigeneHs.653700 [ NCBI ]
CGAP (NCI)Hs.653700
Alternative Splicing GalleryENSG00000043355
Gene ExpressionZIC2 [ NCBI-GEO ]   ZIC2 [ EBI - ARRAY_EXPRESS ]   ZIC2 [ SEEK ]   ZIC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZIC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7546
GTEX Portal (Tissue expression)ZIC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95409   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95409  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95409
Splice isoforms : SwissVarO95409
PhosPhoSitePlusO95409
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZIC2
DMDM Disease mutations7546
Blocks (Seattle)ZIC2
SuperfamilyO95409
Human Protein AtlasENSG00000043355
Peptide AtlasO95409
HPRD04353
IPIIPI00030652   IPI00908526   IPI00872334   
Protein Interaction databases
DIP (DOE-UCLA)O95409
IntAct (EBI)O95409
FunCoupENSG00000043355
BioGRIDZIC2
STRING (EMBL)ZIC2
ZODIACZIC2
Ontologies - Pathways
QuickGOO95409
Ontology : AmiGODNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  brain development  visual perception  nuclear body  cell differentiation  chromatin DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  metal ion binding  positive regulation of sequence-specific DNA binding transcription factor activity  
Ontology : EGO-EBIDNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  brain development  visual perception  nuclear body  cell differentiation  chromatin DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  metal ion binding  positive regulation of sequence-specific DNA binding transcription factor activity  
Pathways : KEGGHedgehog signaling pathway   
NDEx NetworkZIC2
Atlas of Cancer Signalling NetworkZIC2
Wikipedia pathwaysZIC2
Orthology - Evolution
OrthoDB7546
GeneTree (enSembl)ENSG00000043355
Phylogenetic Trees/Animal Genes : TreeFamZIC2
HOVERGENO95409
HOGENOMO95409
Homologs : HomoloGeneZIC2
Homology/Alignments : Family Browser (UCSC)ZIC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZIC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZIC2
dbVarZIC2
ClinVarZIC2
1000_GenomesZIC2 
Exome Variant ServerZIC2
ExAC (Exome Aggregation Consortium)ZIC2 (select the gene name)
Genetic variants : HAPMAP7546
Genomic Variants (DGV)ZIC2 [DGVbeta]
DECIPHERZIC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZIC2 
Mutations
ICGC Data PortalZIC2 
TCGA Data PortalZIC2 
Broad Tumor PortalZIC2
OASIS PortalZIC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZIC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZIC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZIC2
DgiDB (Drug Gene Interaction Database)ZIC2
DoCM (Curated mutations)ZIC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZIC2 (select a term)
intoGenZIC2
Cancer3DZIC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603073    609637   
Orphanet20436    20435    18904    12486    12484    12485   
MedgenZIC2
Genetic Testing Registry ZIC2
NextProtO95409 [Medical]
TSGene7546
GENETestsZIC2
Target ValidationZIC2
Huge Navigator ZIC2 [HugePedia]
snp3D : Map Gene to Disease7546
BioCentury BCIQZIC2
ClinGenZIC2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7546
Chemical/Pharm GKB GenePA37462
Clinical trialZIC2
Miscellaneous
canSAR (ICR)ZIC2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZIC2
EVEXZIC2
GoPubMedZIC2
iHOPZIC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:39:01 CEST 2017
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