| Nomenclature |
|---|
| HGNC (Hugo) | ZIC2 12873 |
| LRG (Locus Reference Genomic) | LRG_1157 |
| Cards |
|---|
| Entrez_Gene (NCBI) | ZIC2 7546 Zic family member 2 |
| Aliases | HPE5 |
| GeneCards (Weizmann) | ZIC2 |
| Ensembl hg19 (Hinxton) | ENSG00000043355 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000043355 [Gene_View] ENSG00000043355 [Sequence] chr13:99981784-99986765 [Contig_View] ZIC2 [Vega] |
| ICGC DataPortal | ENSG00000043355 |
| TCGA cBioPortal | ZIC2 |
| AceView (NCBI) | ZIC2 |
| Genatlas (Paris) | ZIC2 |
| WikiGenes | 7546 |
| SOURCE (Princeton) | ZIC2 |
| Genetics Home Reference (NIH) | ZIC2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | ZIC2 - chr13:99981784-99986765 + 13q32.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | ZIC2 - 13q32.3 [Description] (hg19-Feb_2009) |
| GoldenPath | ZIC2 - 13q32.3 [CytoView hg19] ZIC2 - 13q32.3 [CytoView hg38] |
| ImmunoBase | ENSG00000043355 |
| genome Data Viewer NCBI | ZIC2 [Mapview hg19] |
| OMIM | 603073 609637 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA491603 AF104902 AF188733 AF193855 AF339806 |
| RefSeq transcript (Entrez) | NM_007129 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | ZIC2 |
| Alternative Splicing Gallery | ENSG00000043355 |
| Gene Expression | ZIC2 [ NCBI-GEO ] ZIC2 [ EBI - ARRAY_EXPRESS ]
ZIC2 [ SEEK ] ZIC2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | ZIC2 [ Firebrowse - Broad ] |
| Genevisible | Expression of ZIC2 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 7546 |
| GTEX Portal (Tissue expression) | ZIC2 |
| Human Protein Atlas | ENSG00000043355-ZIC2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O95409 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O95409 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O95409 |
| Splice isoforms : SwissVar | O95409 |
| PhosPhoSitePlus | O95409 |
| Domaine pattern : Prosite (Expaxy) | ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157) |
| Domains : Interpro (EBI) | Znf_C2H2_sf Znf_C2H2_type Znf_ZIC |
| Domain families : Pfam (Sanger) | zf-C2H2 (PF00096) zf_ZIC (PF18366) |
| Domain families : Pfam (NCBI) | pfam00096 pfam18366 |
| Domain families : Smart (EMBL) | ZnF_C2H2 (SM00355) |
| Conserved Domain (NCBI) | ZIC2 |
| DMDM Disease mutations | 7546 |
| Blocks (Seattle) | ZIC2 |
| Superfamily | O95409 |
| Human Protein Atlas [tissue] | ENSG00000043355-ZIC2 [tissue] |
| Peptide Atlas | O95409 |
| HPRD | 04353 |
| IPI | IPI00030652 IPI00908526 IPI00872334 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O95409 |
| IntAct (EBI) | O95409 |
| FunCoup | ENSG00000043355 |
| BioGRID | ZIC2 |
| STRING (EMBL) | ZIC2 |
| ZODIAC | ZIC2 |
| Ontologies - Pathways |
|---|
| QuickGO | O95409 |
| Ontology : AmiGO | RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus nucleoplasm cytoplasm regulation of transcription by RNA polymerase II central nervous system development brain development visual perception nuclear body cell differentiation chromatin DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding positive regulation of DNA-binding transcription factor activity |
| Ontology : EGO-EBI | RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus nucleoplasm cytoplasm regulation of transcription by RNA polymerase II central nervous system development brain development visual perception nuclear body cell differentiation chromatin DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated metal ion binding positive regulation of DNA-binding transcription factor activity |
| Pathways : KEGG | Hedgehog signaling pathway |
| NDEx Network | ZIC2 |
| Atlas of Cancer Signalling Network | ZIC2 |
| Wikipedia pathways | ZIC2 |
| Orthology - Evolution |
|---|
| OrthoDB | 7546 |
| GeneTree (enSembl) | ENSG00000043355 |
| Phylogenetic Trees/Animal Genes : TreeFam | ZIC2 |
| HOGENOM | O95409 |
| Homologs : HomoloGene | ZIC2 |
| Homology/Alignments : Family Browser (UCSC) | ZIC2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | ZIC2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | ZIC2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | ZIC2 |
| dbVar | ZIC2 |
| ClinVar | ZIC2 |
| 1000_Genomes | ZIC2 |
| Exome Variant Server | ZIC2 |
| GNOMAD Browser | ENSG00000043355 |
| Varsome Browser | ZIC2 |
| Genetic variants : HAPMAP | 7546 |
| Genomic Variants (DGV) | ZIC2 [DGVbeta] |
| DECIPHER | ZIC2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | ZIC2 |
| Mutations |
|---|
| ICGC Data Portal | ZIC2 |
| TCGA Data Portal | ZIC2 |
| Broad Tumor Portal | ZIC2 |
| OASIS Portal | ZIC2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | ZIC2 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | ZIC2 |
| Mutations and Diseases : HGMD | ZIC2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search ZIC2 |
| DgiDB (Drug Gene Interaction Database) | ZIC2 |
| DoCM (Curated mutations) | ZIC2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | ZIC2 (select a term) |
| intoGen | ZIC2 |
| Cancer3D | ZIC2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 603073 609637 |
| Orphanet | 20436 20435 18904 12486 12484 12485 |
| DisGeNET | ZIC2 |
| Medgen | ZIC2 |
| Genetic Testing Registry | ZIC2
|
| NextProt | O95409 [Medical] |
| TSGene | 7546 |
| GENETests | ZIC2 |
| Target Validation | ZIC2 |
| Huge Navigator |
ZIC2 [HugePedia] |
| snp3D : Map Gene to Disease | 7546 |
| BioCentury BCIQ | ZIC2 |
| ClinGen | ZIC2 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 7546 |
| Pharm GKB Gene | PA37462 |
| Clinical trial | ZIC2 |
| Miscellaneous |
|---|
| canSAR (ICR) | ZIC2 (select the gene name) |
| Harmonizome | ZIC2 |
| DataMed Index | ZIC2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 59 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | ZIC2 |
| EVEX | ZIC2 |
| GoPubMed | ZIC2 |
