| Nomenclature |
|---|
| HGNC (Hugo) | ZIC2 12873 |
| LRG (Locus Reference Genomic) | LRG_1157 |
| Cards |
|---|
| Entrez_Gene (NCBI) | ZIC2 7546 Zic family member 2 |
| Aliases | HPE5 |
| GeneCards (Weizmann) | ZIC2 |
| Ensembl hg19 (Hinxton) | ENSG00000043355 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000043355 [Gene_View] ENSG00000043355 [Sequence] chr13:99981756-99986773 [Contig_View] ZIC2 [Vega] |
| ICGC DataPortal | ENSG00000043355 |
| TCGA cBioPortal | ZIC2 |
| AceView (NCBI) | ZIC2 |
| Genatlas (Paris) | ZIC2 |
| WikiGenes | 7546 |
| SOURCE (Princeton) | ZIC2 |
| Genetics Home Reference (NIH) | ZIC2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | ZIC2 - chr13:99981756-99986773 + 13q32.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | ZIC2 - 13q32.3 [Description] (hg19-Feb_2009) |
ZIC2 - 13q32.3 [CytoView hg19] ZIC2 - 13q32.3 [CytoView hg38] |
| Mapping of homologs : NCBI | ZIC2 [Mapview hg19] ZIC2 [Mapview hg38] |
| OMIM | 603073 609637 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA491603 AF104902 AF188733 AF193855 AF339806 |
| RefSeq transcript (Entrez) | NM_007129 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | ZIC2 |
| Cluster EST : Unigene | Hs.653700 [ NCBI ] |
| CGAP (NCI) | Hs.653700 |
| Alternative Splicing Gallery | ENSG00000043355 |
| Gene Expression | ZIC2 [ NCBI-GEO ] ZIC2 [ EBI - ARRAY_EXPRESS ]
ZIC2 [ SEEK ] ZIC2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | ZIC2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 7546 |
| GTEX Portal (Tissue expression) | ZIC2 |
| Human Protein Atlas | ENSG00000043355-ZIC2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O95409 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O95409 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O95409 |
| Splice isoforms : SwissVar | O95409 |
| PhosPhoSitePlus | O95409 |
| Domaine pattern : Prosite (Expaxy) | ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157) |
| Domains : Interpro (EBI) | Znf_C2H2_sf Znf_C2H2_type |
| Domain families : Pfam (Sanger) | |
| Domain families : Pfam (NCBI) | |
| Domain families : Smart (EMBL) | ZnF_C2H2 (SM00355) |
| Conserved Domain (NCBI) | ZIC2 |
| DMDM Disease mutations | 7546 |
| Blocks (Seattle) | ZIC2 |
| Superfamily | O95409 |
| Human Protein Atlas [tissue] | ENSG00000043355-ZIC2 [tissue] |
| Peptide Atlas | O95409 |
| HPRD | 04353 |
| IPI | IPI00030652 IPI00908526 IPI00872334 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O95409 |
| IntAct (EBI) | O95409 |
| FunCoup | ENSG00000043355 |
| BioGRID | ZIC2 |
| STRING (EMBL) | ZIC2 |
| ZODIAC | ZIC2 |
| Ontologies - Pathways |
|---|
| QuickGO | O95409 |
| Ontology : AmiGO | RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus nucleus cytoplasm central nervous system development brain development visual perception nuclear body cell differentiation chromatin DNA binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of DNA-binding transcription factor activity |
| Ontology : EGO-EBI | RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity nucleus nucleus nucleus cytoplasm central nervous system development brain development visual perception nuclear body cell differentiation chromatin DNA binding negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of DNA-binding transcription factor activity |
| Pathways : KEGG | Hedgehog signaling pathway |
| NDEx Network | ZIC2 |
| Atlas of Cancer Signalling Network | ZIC2 |
| Wikipedia pathways | ZIC2 |
| Orthology - Evolution |
|---|
| OrthoDB | 7546 |
| GeneTree (enSembl) | ENSG00000043355 |
| Phylogenetic Trees/Animal Genes : TreeFam | ZIC2 |
| HOGENOM | O95409 |
| Homologs : HomoloGene | ZIC2 |
| Homology/Alignments : Family Browser (UCSC) | ZIC2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | ZIC2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | ZIC2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | ZIC2 |
| dbVar | ZIC2 |
| ClinVar | ZIC2 |
| 1000_Genomes | ZIC2 |
| Exome Variant Server | ZIC2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000043355 |
| GNOMAD Browser | ENSG00000043355 |
| Varsome Browser | ZIC2 |
| Genetic variants : HAPMAP | 7546 |
| Genomic Variants (DGV) | ZIC2 [DGVbeta] |
| DECIPHER | ZIC2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | ZIC2 |
| Mutations |
|---|
| ICGC Data Portal | ZIC2 |
| TCGA Data Portal | ZIC2 |
| Broad Tumor Portal | ZIC2 |
| OASIS Portal | ZIC2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | ZIC2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | ZIC2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search ZIC2 |
| DgiDB (Drug Gene Interaction Database) | ZIC2 |
| DoCM (Curated mutations) | ZIC2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | ZIC2 (select a term) |
| intoGen | ZIC2 |
| Cancer3D | ZIC2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 603073 609637 |
| Orphanet | 20436 20435 18904 12486 12484 12485 |
| DisGeNET | ZIC2 |
| Medgen | ZIC2 |
| Genetic Testing Registry | ZIC2
|
| NextProt | O95409 [Medical] |
| TSGene | 7546 |
| GENETests | ZIC2 |
| Target Validation | ZIC2 |
| Huge Navigator |
ZIC2 [HugePedia] |
| snp3D : Map Gene to Disease | 7546 |
| BioCentury BCIQ | ZIC2 |
| ClinGen | ZIC2 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 7546 |
| Chemical/Pharm GKB Gene | PA37462 |
| Clinical trial | ZIC2 |
| Miscellaneous |
|---|
| canSAR (ICR) | ZIC2 (select the gene name) |
| DataMed Index | ZIC2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 56 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | ZIC2 |
| EVEX | ZIC2 |
| GoPubMed | ZIC2 |
| iHOP | ZIC2 |
