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ZIC3 (Zic family member 3)

Identity

Other namesHTX
HTX1
VACTERLX
ZNF203
HGNC (Hugo) ZIC3
LocusID (NCBI) 7547
Atlas_Id 45673
Location Xq26.3
Location_base_pair Starts at 136648346 and ends at 136654259 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ZIC3   12874
Cards
Entrez_Gene (NCBI)ZIC3  7547  Zic family member 3
GeneCards (Weizmann)ZIC3
Ensembl hg19 (Hinxton)ENSG00000156925 [Gene_View]  chrX:136648346-136654259 [Contig_View]  ZIC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000156925 [Gene_View]  chrX:136648346-136654259 [Contig_View]  ZIC3 [Vega]
ICGC DataPortalENSG00000156925
TCGA cBioPortalZIC3
AceView (NCBI)ZIC3
Genatlas (Paris)ZIC3
WikiGenes7547
SOURCE (Princeton)ZIC3
Genomic and cartography
GoldenPath hg19 (UCSC)ZIC3  -     chrX:136648346-136654259 +  Xq26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZIC3  -     Xq26.3   [Description]    (hg38-Dec_2013)
EnsemblZIC3 - Xq26.3 [CytoView hg19]  ZIC3 - Xq26.3 [CytoView hg38]
Mapping of homologs : NCBIZIC3 [Mapview hg19]  ZIC3 [Mapview hg38]
OMIM300265   306955   314390   
Gene and transcription
Genbank (Entrez)AF028706 BC111854 BC113393 BC113395 BM667189
RefSeq transcript (Entrez)NM_003413
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_008115 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)ZIC3
Cluster EST : UnigeneHs.111227 [ NCBI ]
CGAP (NCI)Hs.111227
Alternative Splicing : Fast-db (Paris)GSHG0031845
Alternative Splicing GalleryENSG00000156925
Gene ExpressionZIC3 [ NCBI-GEO ]     ZIC3 [ SEEK ]   ZIC3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60481 (Uniprot)
NextProtO60481  [Medical]
With graphics : InterProO60481
Splice isoforms : SwissVarO60481 (Swissvar)
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrO60481
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations7547
Blocks (Seattle)O60481
PDB (SRS)2EJ4    2RPC   
PDB (PDBSum)2EJ4    2RPC   
PDB (IMB)2EJ4    2RPC   
PDB (RSDB)2EJ4    2RPC   
Human Protein AtlasENSG00000156925
Peptide AtlasO60481
HPRD02225
IPIIPI00029724   IPI00552994   
Protein Interaction databases
DIP (DOE-UCLA)O60481
IntAct (EBI)O60481
FunCoupENSG00000156925
BioGRIDZIC3
IntegromeDBZIC3
STRING (EMBL)ZIC3
Ontologies - Pathways
QuickGOO60481
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  heart looping  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  determination of left/right symmetry  anterior/posterior pattern specification  lung development  somatic stem cell maintenance  determination of pancreatic left/right asymmetry  determination of left/right asymmetry in nervous system  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  determination of digestive tract left/right asymmetry  determination of liver left/right asymmetry  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  heart looping  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  determination of left/right symmetry  anterior/posterior pattern specification  lung development  somatic stem cell maintenance  determination of pancreatic left/right asymmetry  determination of left/right asymmetry in nervous system  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  determination of digestive tract left/right asymmetry  determination of liver left/right asymmetry  
Protein Interaction DatabaseZIC3
DoCM (Curated mutations)ZIC3
Wikipedia pathwaysZIC3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerZIC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZIC3
dbVarZIC3
ClinVarZIC3
1000_GenomesZIC3 
Exome Variant ServerZIC3
SNP (GeneSNP Utah)ZIC3
SNP : HGBaseZIC3
Genetic variants : HAPMAPZIC3
Genomic Variants (DGV)ZIC3 [DGVbeta]
Mutations
ICGC Data PortalZIC3 
TCGA Data PortalZIC3 
Tumor PortalZIC3
Somatic Mutations in Cancer : COSMICZIC3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:136648346-136654259
CONAN: Copy Number AnalysisZIC3 
Mutations and Diseases : HGMDZIC3
OMIM300265    306955    314390   
MedgenZIC3
NextProtO60481 [Medical]
GENETestsZIC3
Disease Genetic AssociationZIC3
Huge Navigator ZIC3 [HugePedia]  ZIC3 [HugeCancerGEM]
snp3D : Map Gene to Disease7547
DGIdb (Drug Gene Interaction db)ZIC3
General knowledge
Homologs : HomoloGeneZIC3
Homology/Alignments : Family Browser (UCSC)ZIC3
Phylogenetic Trees/Animal Genes : TreeFamZIC3
Chemical/Protein Interactions : CTD7547
Chemical/Pharm GKB GenePA37463
Clinical trialZIC3
Cancer Resource (Charite)ENSG00000156925
Other databases
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
CoreMineZIC3
GoPubMedZIC3
iHOPZIC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 20:22:22 CEST 2015

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