Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)

Identity

Alias_namesZNF139
ZNF36
zinc finger protein 36 (KOX 18)
Alias_symbol (synonym)KOX18
PHZ-37
ZSCAN33
Other alias
HGNC (Hugo) ZKSCAN1
LocusID (NCBI) 7586
Atlas_Id 54840
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100015552 and ends at 100041689 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BSG (19p13.3) / ZKSCAN1 (7q22.1)SH3KBP1 (Xp22.12) / ZKSCAN1 (7q22.1)ZKSCAN1 (7q22.1) / ABCG2 (4q22.1)
ZKSCAN1 (7q22.1) / CCDC136 (7q32.1)ZKSCAN1 (7q22.1) / LOC100505876 ()ZKSCAN1 (7q22.1) / NF1 (17q11.2)
ZKSCAN1 (7q22.1) / SNAPC5 (15q22.31)ZKSCAN1 (7q22.1) / SVEP1 (9q31.3)ZKSCAN1 (7q22.1) / ZKSCAN1 (7q22.1)
ZKSCAN1 7q22.1 / CCDC136 7q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(7;7)(q22;q32) ZKSCAN1/CCDC136
t(7;7)(q22;q34) ZKSCAN1/BRAF


External links

Nomenclature
HGNC (Hugo)ZKSCAN1   13101
Cards
Entrez_Gene (NCBI)ZKSCAN1  7586  zinc finger with KRAB and SCAN domains 1
AliasesKOX18; PHZ-37; ZNF139; ZNF36; 
ZSCAN33
GeneCards (Weizmann)ZKSCAN1
Ensembl hg19 (Hinxton)ENSG00000106261 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106261 [Gene_View]  ENSG00000106261 [Sequence]  chr7:100015552-100041689 [Contig_View]  ZKSCAN1 [Vega]
ICGC DataPortalENSG00000106261
TCGA cBioPortalZKSCAN1
AceView (NCBI)ZKSCAN1
Genatlas (Paris)ZKSCAN1
WikiGenes7586
SOURCE (Princeton)ZKSCAN1
Genetics Home Reference (NIH)ZKSCAN1
Genomic and cartography
GoldenPath hg38 (UCSC)ZKSCAN1  -     chr7:100015552-100041689 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZKSCAN1  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblZKSCAN1 - 7q22.1 [CytoView hg19]  ZKSCAN1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIZKSCAN1 [Mapview hg19]  ZKSCAN1 [Mapview hg38]
OMIM601260   
Gene and transcription
Genbank (Entrez)AA873735 AF454940 AK054676 AK056630 AK074116
RefSeq transcript (Entrez)NM_001287054 NM_001287055 NM_001346579 NM_001346580 NM_001346581 NM_003439
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZKSCAN1
Cluster EST : UnigeneHs.743424 [ NCBI ]
CGAP (NCI)Hs.743424
Alternative Splicing GalleryENSG00000106261
Gene ExpressionZKSCAN1 [ NCBI-GEO ]   ZKSCAN1 [ EBI - ARRAY_EXPRESS ]   ZKSCAN1 [ SEEK ]   ZKSCAN1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZKSCAN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7586
GTEX Portal (Tissue expression)ZKSCAN1
Human Protein AtlasENSG00000106261-ZKSCAN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17029   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17029  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17029
Splice isoforms : SwissVarP17029
PhosPhoSitePlusP17029
Domaine pattern : Prosite (Expaxy)KRAB (PS50805)    SCAN_BOX (PS50804)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)KRAB    KRAB_dom_sf    SCAN_dom    SCAN_sf    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)KRAB (PF01352)    SCAN (PF02023)   
Domain families : Pfam (NCBI)pfam01352    pfam02023   
Domain families : Smart (EMBL)KRAB (SM00349)  SCAN (SM00431)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZKSCAN1
DMDM Disease mutations7586
Blocks (Seattle)ZKSCAN1
SuperfamilyP17029
Human Protein Atlas [tissue]ENSG00000106261-ZKSCAN1 [tissue]
Peptide AtlasP17029
HPRD03161
IPIIPI00657757   IPI01012008   IPI00385145   IPI00815876   IPI00926645   IPI00926343   
Protein Interaction databases
DIP (DOE-UCLA)P17029
IntAct (EBI)P17029
FunCoupENSG00000106261
BioGRIDZKSCAN1
STRING (EMBL)ZKSCAN1
ZODIACZKSCAN1
Ontologies - Pathways
QuickGOP17029
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  metal ion binding  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  metal ion binding  
NDEx NetworkZKSCAN1
Atlas of Cancer Signalling NetworkZKSCAN1
Wikipedia pathwaysZKSCAN1
Orthology - Evolution
OrthoDB7586
GeneTree (enSembl)ENSG00000106261
Phylogenetic Trees/Animal Genes : TreeFamZKSCAN1
HOVERGENP17029
HOGENOMP17029
Homologs : HomoloGeneZKSCAN1
Homology/Alignments : Family Browser (UCSC)ZKSCAN1
Gene fusions - Rearrangements
Fusion : MitelmanZKSCAN1/CCDC136 [7q22.1/7q32.1]  
Fusion PortalZKSCAN1 7q22.1 CCDC136 7q32.1 BRCA
Fusion : QuiverZKSCAN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZKSCAN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZKSCAN1
dbVarZKSCAN1
ClinVarZKSCAN1
1000_GenomesZKSCAN1 
Exome Variant ServerZKSCAN1
ExAC (Exome Aggregation Consortium)ENSG00000106261
GNOMAD BrowserENSG00000106261
Varsome BrowserZKSCAN1
Genetic variants : HAPMAP7586
Genomic Variants (DGV)ZKSCAN1 [DGVbeta]
DECIPHERZKSCAN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZKSCAN1 
Mutations
ICGC Data PortalZKSCAN1 
TCGA Data PortalZKSCAN1 
Broad Tumor PortalZKSCAN1
OASIS PortalZKSCAN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZKSCAN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZKSCAN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZKSCAN1
DgiDB (Drug Gene Interaction Database)ZKSCAN1
DoCM (Curated mutations)ZKSCAN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZKSCAN1 (select a term)
intoGenZKSCAN1
Cancer3DZKSCAN1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601260   
Orphanet
DisGeNETZKSCAN1
MedgenZKSCAN1
Genetic Testing Registry ZKSCAN1
NextProtP17029 [Medical]
TSGene7586
GENETestsZKSCAN1
Target ValidationZKSCAN1
Huge Navigator ZKSCAN1 [HugePedia]
snp3D : Map Gene to Disease7586
BioCentury BCIQZKSCAN1
ClinGenZKSCAN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7586
Chemical/Pharm GKB GenePA37676
Clinical trialZKSCAN1
Miscellaneous
canSAR (ICR)ZKSCAN1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZKSCAN1
EVEXZKSCAN1
GoPubMedZKSCAN1
iHOPZKSCAN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:51:09 CET 2018

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