ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)

2014-08-01  

Identity

HGNC
ZKSCAN1
LOCATION
7q22.1
LOCUSID
7586
ALIAS
KOX18,PHZ-37,ZNF139,ZNF36,ZSCAN33
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7586
MIM: 601260
HGNC: 13101
Ensembl: ENSG00000106261

Variants:

dbSNP: 7586
ClinVar: 7586
TCGA: ENSG00000106261
COSMIC: ZKSCAN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106261ENST00000324306P17029
ENSG00000106261ENST00000426572E9PC66
ENSG00000106261ENST00000432317C9JRM9
ENSG00000106261ENST00000535170B3KRF7
ENSG00000106261ENST00000620510E9PC66

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
282112152017ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways.102
312814952019Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.22
248249302014ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells.14
245153892014Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells.9
267224292015Silencing of ZNF139-siRNA induces apoptosis in human gastric cancer cell line BGC823.7
255618012014Zinc finger protein 139 expression in gastric cancer and its clinical significance.6
299568112018miR‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139.6
301268482018ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting miR-185.6
314810662019Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence.5
254363862014Comparative proteomics in gastric cancer cell line BGC823 after ZNF139 gene inhibited with RNA interference.2

Citation

Dessen P

ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54840/zkscan1