ZKSCAN3 (zinc finger with KRAB and SCAN domains 3)

2008-09-01  

Identity

HGNC
ZKSCAN3
LOCATION
6p22.1
LOCUSID
80317
ALIAS
ZF47,ZFP306,ZNF306,ZNF309,ZSCAN13,ZSCAN35,Zfp47,dJ874C20.1,dJ874C20.1.,zfp-47
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80317
MIM: 612791
HGNC: 13853
Ensembl: ENSG00000189298

Variants:

dbSNP: 80317
ClinVar: 80317
TCGA: ENSG00000189298
COSMIC: ZKSCAN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189298ENST00000252211Q9BRR0
ENSG00000189298ENST00000341464Q9BRR0
ENSG00000189298ENST00000377255Q9BRR0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
234343742013ZKSCAN3 is a master transcriptional repressor of autophagy.84
185196922008The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression.26
189408032008Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.20
210575422011Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma.18
274475532016ZKSCAN3 promotes bladder cancer cell proliferation, migration, and invasion.9
271271492016ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor.6
300494382018ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.3
318925552020Prognostic Significance of ZKSCAN3 (ZNF306) Expression in Gastric Carcinoma.1

Citation

Dessen P

ZKSCAN3 (zinc finger with KRAB and SCAN domains 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50355/zkscan3