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ZMYND11 (zinc finger MYND-type containing 11)

Identity

Alias_symbol (synonym)BS69
Other aliasBRAM1
MRD30
HGNC (Hugo) ZMYND11
LocusID (NCBI) 10771
Atlas_Id 53916
Location 10p15.3  [Link to chromosome band 10p15]
Location_base_pair Starts at 135484 and ends at 254637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DIP2C (10p15.3) / ZMYND11 (10p15.3)HLA-H (6p22.1) / ZMYND11 (10p15.3)NUDT5 (10p13) / ZMYND11 (10p15.3)
ZMYND11 (10p15.3) / ZFAND4 (10q11.22)ZMYND11 (10p15.3) / ZMYND11 (10p15.3)DIP2C 10p15.3 / ZMYND11 10p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;17)(p15;q21) ZMYND11/MBTD1


External links

Nomenclature
HGNC (Hugo)ZMYND11   16966
Cards
Entrez_Gene (NCBI)ZMYND11  10771  zinc finger MYND-type containing 11
AliasesBRAM1; BS69; MRD30
GeneCards (Weizmann)ZMYND11
Ensembl hg19 (Hinxton)ENSG00000015171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000015171 [Gene_View]  chr10:135484-254637 [Contig_View]  ZMYND11 [Vega]
ICGC DataPortalENSG00000015171
TCGA cBioPortalZMYND11
AceView (NCBI)ZMYND11
Genatlas (Paris)ZMYND11
WikiGenes10771
SOURCE (Princeton)ZMYND11
Genetics Home Reference (NIH)ZMYND11
Genomic and cartography
GoldenPath hg38 (UCSC)ZMYND11  -     chr10:135484-254637 +  10p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZMYND11  -     10p15.3   [Description]    (hg19-Feb_2009)
EnsemblZMYND11 - 10p15.3 [CytoView hg19]  ZMYND11 - 10p15.3 [CytoView hg38]
Mapping of homologs : NCBIZMYND11 [Mapview hg19]  ZMYND11 [Mapview hg38]
OMIM608668   616083   
Gene and transcription
Genbank (Entrez)AI031881 AI244299 AK294469 AK294781 AK296427
RefSeq transcript (Entrez)NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_001330057 NM_006624 NM_212479
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZMYND11
Cluster EST : UnigeneHs.740145 [ NCBI ]
CGAP (NCI)Hs.740145
Alternative Splicing GalleryENSG00000015171
Gene ExpressionZMYND11 [ NCBI-GEO ]   ZMYND11 [ EBI - ARRAY_EXPRESS ]   ZMYND11 [ SEEK ]   ZMYND11 [ MEM ]
Gene Expression Viewer (FireBrowse)ZMYND11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10771
GTEX Portal (Tissue expression)ZMYND11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15326   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15326  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15326
Splice isoforms : SwissVarQ15326
PhosPhoSitePlusQ15326
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_2 (PS50014)    PWWP (PS50812)    ZF_MYND_1 (PS01360)    ZF_MYND_2 (PS50865)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)Bromodomain    PWWP_dom    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_MYND    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    PWWP (PF00855)   
Domain families : Pfam (NCBI)pfam00439    pfam00855   
Domain families : Smart (EMBL)BROMO (SM00297)  PHD (SM00249)  PWWP (SM00293)  
Conserved Domain (NCBI)ZMYND11
DMDM Disease mutations10771
Blocks (Seattle)ZMYND11
PDB (SRS)4NS5    5HDA   
PDB (PDBSum)4NS5    5HDA   
PDB (IMB)4NS5    5HDA   
PDB (RSDB)4NS5    5HDA   
Structural Biology KnowledgeBase4NS5    5HDA   
SCOP (Structural Classification of Proteins)4NS5    5HDA   
CATH (Classification of proteins structures)4NS5    5HDA   
SuperfamilyQ15326
Human Protein AtlasENSG00000015171
Peptide AtlasQ15326
HPRD09830
IPIIPI00922874   IPI00556262   IPI00982748   IPI00480004   IPI00796117   IPI00873394   IPI00967676   IPI00930718   IPI00878480   IPI00879389   
Protein Interaction databases
DIP (DOE-UCLA)Q15326
IntAct (EBI)Q15326
FunCoupENSG00000015171
BioGRIDZMYND11
STRING (EMBL)ZMYND11
ZODIACZMYND11
Ontologies - Pathways
QuickGOQ15326
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  chromosome  transcription, DNA-templated  cell cycle  zinc ion binding  cell proliferation  viral process  covalent chromatin modification  regulation of transcription elongation from RNA polymerase II promoter  methylated histone binding  histone binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of JNK cascade  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  chromosome  transcription, DNA-templated  cell cycle  zinc ion binding  cell proliferation  viral process  covalent chromatin modification  regulation of transcription elongation from RNA polymerase II promoter  methylated histone binding  histone binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of JNK cascade  negative regulation of extrinsic apoptotic signaling pathway  
NDEx NetworkZMYND11
Atlas of Cancer Signalling NetworkZMYND11
Wikipedia pathwaysZMYND11
Orthology - Evolution
OrthoDB10771
GeneTree (enSembl)ENSG00000015171
Phylogenetic Trees/Animal Genes : TreeFamZMYND11
HOVERGENQ15326
HOGENOMQ15326
Homologs : HomoloGeneZMYND11
Homology/Alignments : Family Browser (UCSC)ZMYND11
Gene fusions - Rearrangements
Fusion : MitelmanDIP2C/ZMYND11 [10p15.3/10p15.3]  [t(10;10)(p15;p15)]  
Fusion: TCGADIP2C 10p15.3 ZMYND11 10p15.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZMYND11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZMYND11
dbVarZMYND11
ClinVarZMYND11
1000_GenomesZMYND11 
Exome Variant ServerZMYND11
ExAC (Exome Aggregation Consortium)ZMYND11 (select the gene name)
Genetic variants : HAPMAP10771
Genomic Variants (DGV)ZMYND11 [DGVbeta]
DECIPHERZMYND11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZMYND11 
Mutations
ICGC Data PortalZMYND11 
TCGA Data PortalZMYND11 
Broad Tumor PortalZMYND11
OASIS PortalZMYND11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZMYND11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZMYND11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZMYND11
DgiDB (Drug Gene Interaction Database)ZMYND11
DoCM (Curated mutations)ZMYND11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZMYND11 (select a term)
intoGenZMYND11
Cancer3DZMYND11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608668    616083   
Orphanet23328   
MedgenZMYND11
Genetic Testing Registry ZMYND11
NextProtQ15326 [Medical]
TSGene10771
GENETestsZMYND11
Target ValidationZMYND11
Huge Navigator ZMYND11 [HugePedia]
snp3D : Map Gene to Disease10771
BioCentury BCIQZMYND11
ClinGenZMYND11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10771
Chemical/Pharm GKB GenePA128394578
Clinical trialZMYND11
Miscellaneous
canSAR (ICR)ZMYND11 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZMYND11
EVEXZMYND11
GoPubMedZMYND11
iHOPZMYND11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:03:37 CEST 2017

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