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ZMYND8 (zinc finger MYND-type containing 8)

Identity

Alias_namesPRKCBP1
protein kinase C binding protein 1
Alias_symbol (synonym)RACK7
Other aliasPRO2893
HGNC (Hugo) ZMYND8
LocusID (NCBI) 23613
Atlas_Id 41853
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 47209214 and ends at 47356889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS4 (20q13.13) / ZMYND8 (20q13.12)NCOA3 (20q13.12) / ZMYND8 (20q13.12)SLC2A10 (20q13.12) / ZMYND8 (20q13.12)
SYCP2 (20q13.33) / ZMYND8 (20q13.12)TAF8 (6p21.1) / ZMYND8 (20q13.12)ZMYND8 (20q13.12) / CELF5 (19p13.3)
ZMYND8 (20q13.12) / CEP250 (20q11.22)ZMYND8 (20q13.12) / EYA2 (20q13.12)ZMYND8 (20q13.12) / GTPBP1 (22q13.1)
ZMYND8 (20q13.12) / IARS (9q22.31)ZMYND8 (20q13.12) / MN1 (22q12.1)ZMYND8 (20q13.12) / PITPNB (22q12.1)
ZMYND8 (20q13.12) / RELA (11q13.1)ZMYND8 (20q13.12) / SLC39A14 (8p21.3)ZMYND8 (20q13.12) / SULF2 (20q13.12)
ZMYND8 (20q13.12) / TYRP1 (9p23)ZMYND8 (20q13.12) / ZC4H2 (Xq11.2)ZMYND8 (20q13.12) / ZMYND8 (20q13.12)
SYCP2 20q13.33 / ZMYND8 20q13.12ZMYND8 20q13.12 / CELF5 19p13.3ZMYND8 20q13.12 / EYA2 20q13.12
ZMYND8 20q13.12 / GTPBP1 22q13.1ZMYND8 20q13.12 / MN1 22q12.1ZMYND8 20q13.12 / PITPNB 22q12.1
ZMYND8 20q13.12 / SULF2 20q13.12ZMYND8 20q13.12 / ZC4H2 Xq11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;20)(q32;q13) ZMYND8/PDGFRB
t(11;20)(q13;q13) ZMYND8/RELA


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 10 ]
  t(X;20)(q11;q13) ZMYND8/ZC4H2
t(19;20)(p13;q13) ZMYND8/CELF5
t(20;20)(q11;q13) ZMYND8/CEP250
BCAS4/ZMYND8 (20q13)
SYCP2/ZMYND8 (20q13)
ZMYND8/EYA2 (20q13)
ZMYND8/SULF2 (20q13)
t(20;22)(q13;q12) ZMYND8/MN1
t(20;22)(q13;q12) ZMYND8/PITPNB
t(20;22)(q13;q13) ZMYND8/GTPBP1


External links

Nomenclature
HGNC (Hugo)ZMYND8   9397
Cards
Entrez_Gene (NCBI)ZMYND8  23613  zinc finger MYND-type containing 8
AliasesPRKCBP1; PRO2893; RACK7
GeneCards (Weizmann)ZMYND8
Ensembl hg19 (Hinxton)ENSG00000101040 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101040 [Gene_View]  ENSG00000101040 [Sequence]  chr20:47209214-47356889 [Contig_View]  ZMYND8 [Vega]
ICGC DataPortalENSG00000101040
TCGA cBioPortalZMYND8
AceView (NCBI)ZMYND8
Genatlas (Paris)ZMYND8
WikiGenes23613
SOURCE (Princeton)ZMYND8
Genetics Home Reference (NIH)ZMYND8
Genomic and cartography
GoldenPath hg38 (UCSC)ZMYND8  -     chr20:47209214-47356889 -  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZMYND8  -     20q13.12   [Description]    (hg19-Feb_2009)
EnsemblZMYND8 - 20q13.12 [CytoView hg19]  ZMYND8 - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBIZMYND8 [Mapview hg19]  ZMYND8 [Mapview hg38]
OMIM615713   
Gene and transcription
Genbank (Entrez)AB032951 AF144233 AF233453 AF273045 AF454056
RefSeq transcript (Entrez)NM_001281769 NM_001281771 NM_001281772 NM_001281773 NM_001281774 NM_001281775 NM_001281776 NM_001281777 NM_001281778 NM_001281779 NM_001281780 NM_001281781 NM_001281782 NM_001281783 NM_001281784 NM_001363714 NM_001363741 NM_012408 NM_183047 NM_183048
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZMYND8
Cluster EST : UnigeneHs.668465 [ NCBI ]
CGAP (NCI)Hs.668465
Alternative Splicing GalleryENSG00000101040
Gene ExpressionZMYND8 [ NCBI-GEO ]   ZMYND8 [ EBI - ARRAY_EXPRESS ]   ZMYND8 [ SEEK ]   ZMYND8 [ MEM ]
Gene Expression Viewer (FireBrowse)ZMYND8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23613
GTEX Portal (Tissue expression)ZMYND8
Human Protein AtlasENSG00000101040-ZMYND8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULU4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULU4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULU4
Splice isoforms : SwissVarQ9ULU4
PhosPhoSitePlusQ9ULU4
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_2 (PS50014)    PWWP (PS50812)    ZF_MYND_1 (PS01360)    ZF_MYND_2 (PS50865)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)Bromodomain    Bromodomain-like_sf    PWWP_dom    RACK7_Bromo_dom    Zinc_finger_PHD-type_CS    ZMYND8    ZMYND8/11_PWWP    Znf_FYVE_PHD    Znf_MYND    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    DUF3544 (PF12064)    PWWP (PF00855)   
Domain families : Pfam (NCBI)pfam00439    pfam12064    pfam00855   
Domain families : Smart (EMBL)BROMO (SM00297)  PHD (SM00249)  PWWP (SM00293)  
Conserved Domain (NCBI)ZMYND8
DMDM Disease mutations23613
Blocks (Seattle)ZMYND8
PDB (SRS)4COS    5B73    5MQ4    5Y1Z   
PDB (PDBSum)4COS    5B73    5MQ4    5Y1Z   
PDB (IMB)4COS    5B73    5MQ4    5Y1Z   
PDB (RSDB)4COS    5B73    5MQ4    5Y1Z   
Structural Biology KnowledgeBase4COS    5B73    5MQ4    5Y1Z   
SCOP (Structural Classification of Proteins)4COS    5B73    5MQ4    5Y1Z   
CATH (Classification of proteins structures)4COS    5B73    5MQ4    5Y1Z   
SuperfamilyQ9ULU4
Human Protein Atlas [tissue]ENSG00000101040-ZMYND8 [tissue]
Peptide AtlasQ9ULU4
HPRD10166
IPIIPI00946867   IPI01008945   IPI01008959   IPI00789719   IPI01008745   IPI01014325   IPI00385321   IPI01008942   IPI00941061   IPI00718938   IPI00719508   IPI00640598   IPI00872983   IPI00741204   IPI00418316   IPI01009867   IPI00941004   IPI00748579   IPI00552796   IPI00032822   IPI00718850   IPI00645483   IPI00942122   IPI00922821   IPI00946226   IPI00946748   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULU4
IntAct (EBI)Q9ULU4
FunCoupENSG00000101040
BioGRIDZMYND8
STRING (EMBL)ZMYND8
ZODIACZMYND8
Ontologies - Pathways
QuickGOQ9ULU4
Ontology : AmiGOtranscription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  negative regulation of cell migration  methylated histone binding  dendritic spine  dendritic shaft  metal ion binding  protein N-terminus binding  positive regulation of filopodium assembly  positive regulation of dendritic spine development  repressing transcription factor binding  lysine-acetylated histone binding  modulation of excitatory postsynaptic potential  regulation of postsynaptic density protein 95 clustering  positive regulation of dendritic spine maintenance  negative regulation of transcription from RNA polymerase II promoter by histone modification  
Ontology : EGO-EBItranscription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  negative regulation of cell migration  methylated histone binding  dendritic spine  dendritic shaft  metal ion binding  protein N-terminus binding  positive regulation of filopodium assembly  positive regulation of dendritic spine development  repressing transcription factor binding  lysine-acetylated histone binding  modulation of excitatory postsynaptic potential  regulation of postsynaptic density protein 95 clustering  positive regulation of dendritic spine maintenance  negative regulation of transcription from RNA polymerase II promoter by histone modification  
NDEx NetworkZMYND8
Atlas of Cancer Signalling NetworkZMYND8
Wikipedia pathwaysZMYND8
Orthology - Evolution
OrthoDB23613
GeneTree (enSembl)ENSG00000101040
Phylogenetic Trees/Animal Genes : TreeFamZMYND8
HOVERGENQ9ULU4
HOGENOMQ9ULU4
Homologs : HomoloGeneZMYND8
Homology/Alignments : Family Browser (UCSC)ZMYND8
Gene fusions - Rearrangements
Fusion : MitelmanBCAS4/ZMYND8 [20q13.13/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanSYCP2/ZMYND8 [20q13.33/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanZMYND8/CELF5 [20q13.12/19p13.3]  [t(19;20)(p13;q13)]  
Fusion : MitelmanZMYND8/CEP250 [20q13.12/20q11.22]  [t(20;20)(q11;q13)]  
Fusion : MitelmanZMYND8/EYA2 [20q13.12/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanZMYND8/GTPBP1 [20q13.12/22q13.1]  [t(20;22)(q13;q13)]  
Fusion : MitelmanZMYND8/MN1 [20q13.12/22q12.1]  [t(20;22)(q13;q12)]  
Fusion : MitelmanZMYND8/PITPNB [20q13.12/22q12.1]  [t(20;22)(q13;q12)]  
Fusion : MitelmanZMYND8/RELA [20q13.12/11q13.1]  [t(11;20)(q13;q13)]  
Fusion : MitelmanZMYND8/SULF2 [20q13.12/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanZMYND8/ZC4H2 [20q13.12/Xq11.2]  [t(X;20)(q11;q13)]  
Fusion PortalSYCP2 20q13.33 ZMYND8 20q13.12 BRCA
Fusion PortalZMYND8 20q13.12 CELF5 19p13.3 BRCA
Fusion PortalZMYND8 20q13.12 EYA2 20q13.12 OV
Fusion PortalZMYND8 20q13.12 GTPBP1 22q13.1 BRCA
Fusion PortalZMYND8 20q13.12 MN1 22q12.1 BRCA
Fusion PortalZMYND8 20q13.12 PITPNB 22q12.1 BRCA
Fusion PortalZMYND8 20q13.12 SULF2 20q13.12 OV
Fusion PortalZMYND8 20q13.12 ZC4H2 Xq11.2 BRCA
Fusion Cancer (Beijing)ZMYND8 [20q13.12]  -  TYRP1 [9p23]  [FUSC003807]
Fusion : QuiverZMYND8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZMYND8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZMYND8
dbVarZMYND8
ClinVarZMYND8
1000_GenomesZMYND8 
Exome Variant ServerZMYND8
ExAC (Exome Aggregation Consortium)ENSG00000101040
GNOMAD BrowserENSG00000101040
Varsome BrowserZMYND8
Genetic variants : HAPMAP23613
Genomic Variants (DGV)ZMYND8 [DGVbeta]
DECIPHERZMYND8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZMYND8 
Mutations
ICGC Data PortalZMYND8 
TCGA Data PortalZMYND8 
Broad Tumor PortalZMYND8
OASIS PortalZMYND8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZMYND8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZMYND8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZMYND8
DgiDB (Drug Gene Interaction Database)ZMYND8
DoCM (Curated mutations)ZMYND8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZMYND8 (select a term)
intoGenZMYND8
Cancer3DZMYND8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615713   
Orphanet
DisGeNETZMYND8
MedgenZMYND8
Genetic Testing Registry ZMYND8
NextProtQ9ULU4 [Medical]
TSGene23613
GENETestsZMYND8
Target ValidationZMYND8
Huge Navigator ZMYND8 [HugePedia]
snp3D : Map Gene to Disease23613
BioCentury BCIQZMYND8
ClinGenZMYND8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23613
Chemical/Pharm GKB GenePA162409890
Clinical trialZMYND8
Miscellaneous
canSAR (ICR)ZMYND8 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZMYND8
EVEXZMYND8
GoPubMedZMYND8
iHOPZMYND8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:51:12 CET 2018

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