ZNF143 (zinc finger protein 143)

2003-05-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
SBF,STAF,pHZ-1
FUSION GENES

Other Information

Locus ID:

NCBI: 7702
MIM: 603433
HGNC: 12928
Ensembl: ENSG00000166478

Variants:

dbSNP: 7702
ClinVar: 7702
TCGA: ENSG00000166478
COSMIC: ZNF143

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166478ENST00000299606E7EN86
ENSG00000166478ENST00000396597P52747
ENSG00000166478ENST00000396602P52747
ENSG00000166478ENST00000396604P52747
ENSG00000166478ENST00000412390C9JRS3
ENSG00000166478ENST00000414370C9JCG1
ENSG00000166478ENST00000417726C9J2G7
ENSG00000166478ENST00000438144C9JTC5
ENSG00000166478ENST00000447186H7C1P6
ENSG00000166478ENST00000496276E9PLS7
ENSG00000166478ENST00000526657E9PS81
ENSG00000166478ENST00000530463P52747
ENSG00000166478ENST00000531943E9PPB0
ENSG00000166478ENST00000532577E9PLN4
ENSG00000166478ENST00000533542E9PMY8
ENSG00000166478ENST00000534265E9PJF2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
256450532015ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters.60
179382082007CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription.34
235391392013HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.28
172974372007ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes.25
174785122007Transcription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143.25
208607702010Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes.22
274490342016ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway.19
240090652014A role of zinc-finger protein 143 for cancer cell migration and invasion through ZEB1 and E-cadherin in colon cancer cells.17
211776542011Genome-wide evidence for an essential role of the human Staf/ZNF143 transcription factor in bidirectional transcription.15
147023492004ZNF143 mediates basal and tissue-specific expression of human transaldolase.13

Citation

Dessen P

ZNF143 (zinc finger protein 143)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42871/znf143