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ZNF146 (zinc finger protein 146)

Written2000-10Gérard.Goubin
Laboratoire d'Oncogenöse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)OZF
Other alias
HGNC (Hugo) ZNF146
LocusID (NCBI) 7705
Atlas_Id 267
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 36214602 and ends at 36238773 bp from pter ( according to hg19-Feb_2009)  [Mapping ZNF146.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF146 (19q13.12) / NCAM2 (21q21.1)ZNF146 (19q13.12) / UTP11 (1p34.3)

Protein

Description 33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression in most proliferating tissues
Localisation nucleus
Function represse gene expression through a consensus motive

Implicated in

Note
Disease tumors of the exocrine pancreas
Cytogenetics amplification of the 19q13.1 region in a subset of pancreatic tumors
  

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.
Le Chalony C, Prospéri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G
Journal of molecular biology. 1994 ; 236 (2) : 399-404.
PMID 8107129
 

Citation

This paper should be referenced as such :
Goubin, G
ZNF146 (zinc finger protein 146)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):197-197.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;21)(q13;q21) ZNF146/NCAM2

External links

Nomenclature
HGNC (Hugo)ZNF146   12931
Cards
AtlasOZFID267
Entrez_Gene (NCBI)ZNF146  7705  zinc finger protein 146
AliasesOZF
GeneCards (Weizmann)ZNF146
Ensembl hg19 (Hinxton)ENSG00000167635 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167635 [Gene_View]  ENSG00000167635 [Sequence]  chr19:36214602-36238773 [Contig_View]  ZNF146 [Vega]
ICGC DataPortalENSG00000167635
TCGA cBioPortalZNF146
AceView (NCBI)ZNF146
Genatlas (Paris)ZNF146
WikiGenes7705
SOURCE (Princeton)ZNF146
Genetics Home Reference (NIH)ZNF146
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF146  -     chr19:36214602-36238773 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF146  -     19q13.12   [Description]    (hg19-Feb_2009)
GoldenPathZNF146 - 19q13.12 [CytoView hg19]  ZNF146 - 19q13.12 [CytoView hg38]
ImmunoBaseENSG00000167635
Mapping of homologs : NCBIZNF146 [Mapview hg19]  ZNF146 [Mapview hg38]
OMIM601505   
Gene and transcription
Genbank (Entrez)AI039686 AK311486 AK313460 BC005154 BC065568
RefSeq transcript (Entrez)NM_001099638 NM_001099639 NM_007145
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF146
Cluster EST : UnigeneHs.643436 [ NCBI ]
CGAP (NCI)Hs.643436
Alternative Splicing GalleryENSG00000167635
Gene ExpressionZNF146 [ NCBI-GEO ]   ZNF146 [ EBI - ARRAY_EXPRESS ]   ZNF146 [ SEEK ]   ZNF146 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF146 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7705
GTEX Portal (Tissue expression)ZNF146
Human Protein AtlasENSG00000167635-ZNF146 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15072   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15072  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15072
Splice isoforms : SwissVarQ15072
PhosPhoSitePlusQ15072
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF146
DMDM Disease mutations7705
Blocks (Seattle)ZNF146
SuperfamilyQ15072
Human Protein Atlas [tissue]ENSG00000167635-ZNF146 [tissue]
Peptide AtlasQ15072
HPRD03296
IPIIPI00014305   
Protein Interaction databases
DIP (DOE-UCLA)Q15072
IntAct (EBI)Q15072
FunCoupENSG00000167635
BioGRIDZNF146
STRING (EMBL)ZNF146
ZODIACZNF146
Ontologies - Pathways
QuickGOQ15072
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  nucleus  nucleolus  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  heparin binding  zinc ion binding  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  nucleus  nucleolus  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  heparin binding  zinc ion binding  
NDEx NetworkZNF146
Atlas of Cancer Signalling NetworkZNF146
Wikipedia pathwaysZNF146
Orthology - Evolution
OrthoDB7705
GeneTree (enSembl)ENSG00000167635
Phylogenetic Trees/Animal Genes : TreeFamZNF146
HOGENOMQ15072
Homologs : HomoloGeneZNF146
Homology/Alignments : Family Browser (UCSC)ZNF146
Gene fusions - Rearrangements
Fusion : MitelmanZNF146/NCAM2 [19q13.12/21q21.1]  
Fusion PortalZNF146 19q13.12 AD000671.1 LGG
Fusion PortalZNF146 19q13.12 NCAM2 21q21.1 LUAD
Fusion : FusionGDB40310    43022    43023    43024    43025    7197   
Fusion : Fusion_HubATP5A1--ZNF146    CHD9--ZNF146    CHST8--ZNF146    HACD3--ZNF146    SEL1L3--ZNF146    ZNF146--ABCA9    ZNF146--AD000671.1    ZNF146--ARL8A    ZNF146--C4ORF32    ZNF146--CRISPLD2    ZNF146--EEF1D    ZNF146--EIF1AX    ZNF146--EIF3K    ZNF146--LDHB    ZNF146--NCAM2   
ZNF146--PGPEP1    ZNF146--USP45   
Fusion : QuiverZNF146
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF146 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF146
dbVarZNF146
ClinVarZNF146
1000_GenomesZNF146 
Exome Variant ServerZNF146
ExAC (Exome Aggregation Consortium)ENSG00000167635
GNOMAD BrowserENSG00000167635
Varsome BrowserZNF146
Genetic variants : HAPMAP7705
Genomic Variants (DGV)ZNF146 [DGVbeta]
DECIPHERZNF146 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF146 
Mutations
ICGC Data PortalZNF146 
TCGA Data PortalZNF146 
Broad Tumor PortalZNF146
OASIS PortalZNF146 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF146  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF146
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF146
DgiDB (Drug Gene Interaction Database)ZNF146
DoCM (Curated mutations)ZNF146 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF146 (select a term)
intoGenZNF146
NCG5 (London)ZNF146
Cancer3DZNF146(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601505   
Orphanet
DisGeNETZNF146
MedgenZNF146
Genetic Testing Registry ZNF146
NextProtQ15072 [Medical]
TSGene7705
GENETestsZNF146
Target ValidationZNF146
Huge Navigator ZNF146 [HugePedia]
snp3D : Map Gene to Disease7705
BioCentury BCIQZNF146
ClinGenZNF146
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7705
Chemical/Pharm GKB GenePA37518
Clinical trialZNF146
Miscellaneous
canSAR (ICR)ZNF146 (select the gene name)
DataMed IndexZNF146
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF146
EVEXZNF146
GoPubMedZNF146
iHOPZNF146
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 7 18:36:18 CEST 2019
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