ZNF268 (zinc finger protein 268)

2013-03-01  

Identity

HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
HZF3
FUSION GENES

Other Information

Locus ID:

NCBI: 10795
MIM: 604753
HGNC: 13061
Ensembl: ENSG00000090612

Variants:

dbSNP: 10795
ClinVar: 10795
TCGA: ENSG00000090612
COSMIC: ZNF268

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090612ENST00000228289Q14587
ENSG00000090612ENST00000416488E7EV44
ENSG00000090612ENST00000500625K7EMS6
ENSG00000090612ENST00000536435Q14587
ENSG00000090612ENST00000536899F5H1T2
ENSG00000090612ENST00000539248Q14587
ENSG00000090612ENST00000541009A0A075B6T9
ENSG00000090612ENST00000541211F5H7L3
ENSG00000090612ENST00000541975F5H467
ENSG00000090612ENST00000542711F5H670
ENSG00000090612ENST00000542986F5H848
ENSG00000090612ENST00000546126F5H6R9
ENSG00000090612ENST00000588312Q14587
ENSG00000090612ENST00000591951K7EIF0
ENSG00000090612ENST00000592241K7EQP6
ENSG00000090612ENST00000611984A0A087WV54

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183753842008Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.12
222353042012Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.12
168652302006KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains.10
230910552012The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.10
236658722013Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.10
155476612004ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development.8
167879222006Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element.8
128228882003The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.6
189494282008Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.6
186770942008A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.5

Citation

Dessen P

ZNF268 (zinc finger protein 268)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53202/znf268