ZNF382 (zinc finger protein 382)

2010-11-01  

Identity

HGNC
ZNF382
LOCATION
19q13.12
LOCUSID
84911
ALIAS
KS1

Other Information

Locus ID:

NCBI: 84911
MIM: 609516
HGNC: 17409
Ensembl: ENSG00000161298

Variants:

dbSNP: 84911
ClinVar: 84911
TCGA: ENSG00000161298
COSMIC: ZNF382

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161298ENST00000292928Q96SR6
ENSG00000161298ENST00000423582C9JME7
ENSG00000161298ENST00000435416Q96SR6
ENSG00000161298ENST00000439428Q96SR6
ENSG00000161298ENST00000460670K7EQ52
ENSG00000161298ENST00000590785K7EK67
ENSG00000161298ENST00000639288A0A1W2PRV3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206827942010KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas.56
250092982014Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis.35
218767672011MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression.17
297603762018The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/β-catenin signalling.6
299567352018KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer.5
308044582019Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis.4
124591822002Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart.2
253190492014Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients.2
316782732020ZNF382: A transcription inhibitor down-regulated in multiple tumors due to promoter methylation.0

Citation

Dessen P

ZNF382 (zinc finger protein 382)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51753/znf382