Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZNF395 (zinc finger protein 395)

Identity

Alias_symbol (synonym)PRF-1
HDBP2
PBF
DKFZp434K1210
Other aliasHDBP-2
HDRF-2
PRF1
Si-1-8-14
HGNC (Hugo) ZNF395
LocusID (NCBI) 55893
Atlas_Id 50674
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 28345585 and ends at 28386460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDCA8 (1p34.3) / ZNF395 (8p21.1)RRP7A (22q13.2) / ZNF395 (8p21.1)ZNF395 (8p21.1) / SLC25A44 (1q22)
ZNF395 (8p21.1) / ZNF395 (8p21.1)ZNF395 8p21.1 / SLC25A44 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;8)(q22;p21) ZNF395/SLC25A44

External links

Nomenclature
HGNC (Hugo)ZNF395   18737
Cards
Entrez_Gene (NCBI)ZNF395  55893  zinc finger protein 395
AliasesHDBP-2; HDBP2; HDRF-2; PBF; 
PRF-1; PRF1; Si-1-8-14
GeneCards (Weizmann)ZNF395
Ensembl hg19 (Hinxton)ENSG00000186918 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186918 [Gene_View]  ENSG00000186918 [Sequence]  chr8:28345585-28386460 [Contig_View]  ZNF395 [Vega]
ICGC DataPortalENSG00000186918
TCGA cBioPortalZNF395
AceView (NCBI)ZNF395
Genatlas (Paris)ZNF395
WikiGenes55893
SOURCE (Princeton)ZNF395
Genetics Home Reference (NIH)ZNF395
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF395  -     chr8:28345585-28386460 -  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF395  -     8p21.1   [Description]    (hg19-Feb_2009)
EnsemblZNF395 - 8p21.1 [CytoView hg19]  ZNF395 - 8p21.1 [CytoView hg38]
Mapping of homologs : NCBIZNF395 [Mapview hg19]  ZNF395 [Mapview hg38]
OMIM609494   
Gene and transcription
Genbank (Entrez)AB044750 AB044751 AB044752 AB057659 AB073627
RefSeq transcript (Entrez)NM_018660
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF395
Cluster EST : UnigeneHs.695998 [ NCBI ]
CGAP (NCI)Hs.695998
Alternative Splicing GalleryENSG00000186918
Gene ExpressionZNF395 [ NCBI-GEO ]   ZNF395 [ EBI - ARRAY_EXPRESS ]   ZNF395 [ SEEK ]   ZNF395 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF395 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55893
GTEX Portal (Tissue expression)ZNF395
Human Protein AtlasENSG00000186918-ZNF395 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H8N7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H8N7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H8N7
Splice isoforms : SwissVarQ9H8N7
PhosPhoSitePlusQ9H8N7
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)DUF4772    Znf_C2H2_type   
Domain families : Pfam (Sanger)DUF4772 (PF15997)   
Domain families : Pfam (NCBI)pfam15997   
Conserved Domain (NCBI)ZNF395
DMDM Disease mutations55893
Blocks (Seattle)ZNF395
SuperfamilyQ9H8N7
Human Protein Atlas [tissue]ENSG00000186918-ZNF395 [tissue]
Peptide AtlasQ9H8N7
HPRD11711
IPIIPI00386410   IPI00014339   IPI00979606   IPI00980800   IPI00984906   IPI00980198   IPI00983136   IPI00982549   
Protein Interaction databases
DIP (DOE-UCLA)Q9H8N7
IntAct (EBI)Q9H8N7
FunCoupENSG00000186918
BioGRIDZNF395
STRING (EMBL)ZNF395
ZODIACZNF395
Ontologies - Pathways
QuickGOQ9H8N7
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  enhancer sequence-specific DNA binding  DNA binding  nucleus  cytoplasm  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  metal ion binding  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  enhancer sequence-specific DNA binding  DNA binding  nucleus  cytoplasm  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  metal ion binding  
NDEx NetworkZNF395
Atlas of Cancer Signalling NetworkZNF395
Wikipedia pathwaysZNF395
Orthology - Evolution
OrthoDB55893
GeneTree (enSembl)ENSG00000186918
Phylogenetic Trees/Animal Genes : TreeFamZNF395
HOGENOMQ9H8N7
Homologs : HomoloGeneZNF395
Homology/Alignments : Family Browser (UCSC)ZNF395
Gene fusions - Rearrangements
Fusion : MitelmanZNF395/SLC25A44 [8p21.1/1q22]  
Fusion PortalZNF395 8p21.1 SLC25A44 1q22 PRAD
Fusion : QuiverZNF395
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF395 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF395
dbVarZNF395
ClinVarZNF395
1000_GenomesZNF395 
Exome Variant ServerZNF395
ExAC (Exome Aggregation Consortium)ENSG00000186918
GNOMAD BrowserENSG00000186918
Varsome BrowserZNF395
Genetic variants : HAPMAP55893
Genomic Variants (DGV)ZNF395 [DGVbeta]
DECIPHERZNF395 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF395 
Mutations
ICGC Data PortalZNF395 
TCGA Data PortalZNF395 
Broad Tumor PortalZNF395
OASIS PortalZNF395 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF395  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF395
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF395
DgiDB (Drug Gene Interaction Database)ZNF395
DoCM (Curated mutations)ZNF395 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF395 (select a term)
intoGenZNF395
Cancer3DZNF395(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609494   
Orphanet
DisGeNETZNF395
MedgenZNF395
Genetic Testing Registry ZNF395
NextProtQ9H8N7 [Medical]
TSGene55893
GENETestsZNF395
Target ValidationZNF395
Huge Navigator ZNF395 [HugePedia]
snp3D : Map Gene to Disease55893
BioCentury BCIQZNF395
ClinGenZNF395
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55893
Chemical/Pharm GKB GenePA134978145
Clinical trialZNF395
Miscellaneous
canSAR (ICR)ZNF395 (select the gene name)
DataMed IndexZNF395
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF395
EVEXZNF395
GoPubMedZNF395
iHOPZNF395
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 17:07:01 CET 2019
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