ZNF420 (zinc finger protein 420)

2010-10-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
APAK
FUSION GENES

Other Information

Locus ID:

NCBI: 147923
MIM: 617216
HGNC: 20649
Ensembl: ENSG00000197050

Variants:

dbSNP: 147923
ClinVar: 147923
TCGA: ENSG00000197050
COSMIC: ZNF420

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197050ENST00000304239Q8TAQ5
ENSG00000197050ENST00000337995Q8TAQ5
ENSG00000197050ENST00000585862K7ESJ1
ENSG00000197050ENST00000587029K7ELF6
ENSG00000197050ENST00000587082K7EPG0
ENSG00000197050ENST00000589245K7EQC9
ENSG00000197050ENST00000589461K7EJW2
ENSG00000197050ENST00000590332K7ERS3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193774692009KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.46
259619322016H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.18
223340682012Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.8
207130542010ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.5
196296432010Differential regulation of Apak by various DNA damage signals.1
256914622015ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.0

Citation

Dessen P

ZNF420 (zinc finger protein 420)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51718/znf420