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ZNF451 (zinc finger protein 451)

Identity

Alias_symbol (synonym)KIAA0576
COASTER
dJ417I1.1
KIAA1702
Other alias
HGNC (Hugo) ZNF451
LocusID (NCBI) 26036
Atlas_Id 50448
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 57090030 and ends at 57170300 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG2 (6p11.2) / ZNF451 (6p12.1)TMEM33 (4p13) / ZNF451 (6p12.1)ZNF451 (6p12.1) / DLGAP1 (18p11.31)
ZNF451 (6p12.1) / NADSYN1 (11q13.4)ZNF451 (6p12.1) / ZNF451 (6p12.1)BAG2 6p11.2 / ZNF451 6p12.1
ZNF451 6p12.1 / NADSYN1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p11;p12) BAG2/ZNF451
t(6;11)(p12;q13) ZNF451/NADSYN1


External links

Nomenclature
HGNC (Hugo)ZNF451   21091
Cards
Entrez_Gene (NCBI)ZNF451  26036  zinc finger protein 451
AliasesCOASTER; dJ417I1.1
GeneCards (Weizmann)ZNF451
Ensembl hg19 (Hinxton)ENSG00000112200 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112200 [Gene_View]  ENSG00000112200 [Sequence]  chr6:57090030-57170300 [Contig_View]  ZNF451 [Vega]
ICGC DataPortalENSG00000112200
TCGA cBioPortalZNF451
AceView (NCBI)ZNF451
Genatlas (Paris)ZNF451
WikiGenes26036
SOURCE (Princeton)ZNF451
Genetics Home Reference (NIH)ZNF451
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF451  -     chr6:57090030-57170300 +  6p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF451  -     6p12.1   [Description]    (hg19-Feb_2009)
EnsemblZNF451 - 6p12.1 [CytoView hg19]  ZNF451 - 6p12.1 [CytoView hg38]
Mapping of homologs : NCBIZNF451 [Mapview hg19]  ZNF451 [Mapview hg38]
OMIM615708   
Gene and transcription
Genbank (Entrez)AA336048 AB011148 AB051489 AK000983 AK027074
RefSeq transcript (Entrez)NM_001031623 NM_001257273 NM_015555
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF451
Cluster EST : UnigeneHs.705485 [ NCBI ]
CGAP (NCI)Hs.705485
Alternative Splicing GalleryENSG00000112200
Gene ExpressionZNF451 [ NCBI-GEO ]   ZNF451 [ EBI - ARRAY_EXPRESS ]   ZNF451 [ SEEK ]   ZNF451 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF451 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26036
GTEX Portal (Tissue expression)ZNF451
Human Protein AtlasENSG00000112200-ZNF451 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4E5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4E5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4E5
Splice isoforms : SwissVarQ9Y4E5
PhosPhoSitePlusQ9Y4E5
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF451
DMDM Disease mutations26036
Blocks (Seattle)ZNF451
PDB (SRS)5D2M   
PDB (PDBSum)5D2M   
PDB (IMB)5D2M   
PDB (RSDB)5D2M   
Structural Biology KnowledgeBase5D2M   
SCOP (Structural Classification of Proteins)5D2M   
CATH (Classification of proteins structures)5D2M   
SuperfamilyQ9Y4E5
Human Protein Atlas [tissue]ENSG00000112200-ZNF451 [tissue]
Peptide AtlasQ9Y4E5
HPRD10332
IPIIPI00000725   IPI00375612   IPI00384690   IPI00479456   IPI00478349   IPI00967277   IPI00965588   IPI00965094   IPI00963886   IPI00966792   IPI00965356   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4E5
IntAct (EBI)Q9Y4E5
FunCoupENSG00000112200
BioGRIDZNF451
STRING (EMBL)ZNF451
ZODIACZNF451
Ontologies - Pathways
QuickGOQ9Y4E5
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleic acid binding  transcription corepressor activity  protein binding  nucleus  nucleus  regulation of gene expression  PML body  protein sumoylation  protein sumoylation  negative regulation of transforming growth factor beta receptor signaling pathway  histone methyltransferase complex  metal ion binding  negative regulation of transcription initiation from RNA polymerase II promoter  SUMO ligase activity  negative regulation of histone H3-K9 acetylation  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleic acid binding  transcription corepressor activity  protein binding  nucleus  nucleus  regulation of gene expression  PML body  protein sumoylation  protein sumoylation  negative regulation of transforming growth factor beta receptor signaling pathway  histone methyltransferase complex  metal ion binding  negative regulation of transcription initiation from RNA polymerase II promoter  SUMO ligase activity  negative regulation of histone H3-K9 acetylation  
NDEx NetworkZNF451
Atlas of Cancer Signalling NetworkZNF451
Wikipedia pathwaysZNF451
Orthology - Evolution
OrthoDB26036
GeneTree (enSembl)ENSG00000112200
Phylogenetic Trees/Animal Genes : TreeFamZNF451
HOVERGENQ9Y4E5
HOGENOMQ9Y4E5
Homologs : HomoloGeneZNF451
Homology/Alignments : Family Browser (UCSC)ZNF451
Gene fusions - Rearrangements
Fusion : MitelmanBAG2/ZNF451 [6p11.2/6p12.1]  [t(6;6)(p11;p12)]  
Fusion : MitelmanZNF451/NADSYN1 [6p12.1/11q13.4]  [t(6;11)(p12;q13)]  
Fusion PortalBAG2 6p11.2 ZNF451 6p12.1 BRCA
Fusion PortalZNF451 6p12.1 NADSYN1 11q13.4 BRCA
Fusion : QuiverZNF451
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF451 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF451
dbVarZNF451
ClinVarZNF451
1000_GenomesZNF451 
Exome Variant ServerZNF451
ExAC (Exome Aggregation Consortium)ENSG00000112200
GNOMAD BrowserENSG00000112200
Varsome BrowserZNF451
Genetic variants : HAPMAP26036
Genomic Variants (DGV)ZNF451 [DGVbeta]
DECIPHERZNF451 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF451 
Mutations
ICGC Data PortalZNF451 
TCGA Data PortalZNF451 
Broad Tumor PortalZNF451
OASIS PortalZNF451 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF451  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF451
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF451
DgiDB (Drug Gene Interaction Database)ZNF451
DoCM (Curated mutations)ZNF451 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF451 (select a term)
intoGenZNF451
Cancer3DZNF451(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615708   
Orphanet
DisGeNETZNF451
MedgenZNF451
Genetic Testing Registry ZNF451
NextProtQ9Y4E5 [Medical]
TSGene26036
GENETestsZNF451
Target ValidationZNF451
Huge Navigator ZNF451 [HugePedia]
snp3D : Map Gene to Disease26036
BioCentury BCIQZNF451
ClinGenZNF451
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26036
Chemical/Pharm GKB GenePA134967635
Clinical trialZNF451
Miscellaneous
canSAR (ICR)ZNF451 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF451
EVEXZNF451
GoPubMedZNF451
iHOPZNF451
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:51:33 CET 2018

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