Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ZNF521 (zinc finger protein 521)

Identity

Alias_symbol (synonym)EHZF
Evi3
Other alias
HGNC (Hugo) ZNF521
LocusID (NCBI) 25925
Atlas_Id 44033
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 25061924 and ends at 25352250 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DTNA (18q12.1) / ZNF521 (18q11.2)LAMA3 (18q11.2) / ZNF521 (18q11.2)PARD3 (10p11.22) / ZNF521 (18q11.2)
PAX5 (9p13.2) / ZNF521 (18q11.2)ZNF160 (19q13.41) / ZNF521 (18q11.2)ZNF521 (18q11.2) / PAX5 (9p13.2)
ZNF521 (18q11.2) / RGS5 (1q23.3)ZNF521 (18q11.2) / RPL6 (12q24.13)DTNA 18q12.1 / ZNF521 18q11.2
LAMA3 18q11.2 / ZNF521 18q11.2PARD3 10p11.22 / ZNF521 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;18)(p13;q11) PAX5/ZNF521


External links

Nomenclature
HGNC (Hugo)ZNF521   24605
Cards
Entrez_Gene (NCBI)ZNF521  25925  zinc finger protein 521
AliasesEHZF; Evi3
GeneCards (Weizmann)ZNF521
Ensembl hg19 (Hinxton)ENSG00000198795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198795 [Gene_View]  chr18:25061924-25352250 [Contig_View]  ZNF521 [Vega]
ICGC DataPortalENSG00000198795
TCGA cBioPortalZNF521
AceView (NCBI)ZNF521
Genatlas (Paris)ZNF521
WikiGenes25925
SOURCE (Princeton)ZNF521
Genetics Home Reference (NIH)ZNF521
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF521  -     chr18:25061924-25352250 -  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF521  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblZNF521 - 18q11.2 [CytoView hg19]  ZNF521 - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBIZNF521 [Mapview hg19]  ZNF521 [Mapview hg38]
OMIM610974   
Gene and transcription
Genbank (Entrez)AF141339 AJ518106 AK021452 AK027354 AK074046
RefSeq transcript (Entrez)NM_001308225 NM_015461
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF521
Cluster EST : UnigeneHs.116935 [ NCBI ]
CGAP (NCI)Hs.116935
Alternative Splicing GalleryENSG00000198795
Gene ExpressionZNF521 [ NCBI-GEO ]   ZNF521 [ EBI - ARRAY_EXPRESS ]   ZNF521 [ SEEK ]   ZNF521 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF521 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25925
GTEX Portal (Tissue expression)ZNF521
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96K83   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96K83  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96K83
Splice isoforms : SwissVarQ96K83
PhosPhoSitePlusQ96K83
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-C2H2_6 (PF13912)   
Domain families : Pfam (NCBI)pfam13912   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF521
DMDM Disease mutations25925
Blocks (Seattle)ZNF521
SuperfamilyQ96K83
Human Protein AtlasENSG00000198795
Peptide AtlasQ96K83
HPRD18350
IPIIPI00478090   IPI01009570   IPI00217934   
Protein Interaction databases
DIP (DOE-UCLA)Q96K83
IntAct (EBI)Q96K83
FunCoupENSG00000198795
BioGRIDZNF521
STRING (EMBL)ZNF521
ZODIACZNF521
Ontologies - Pathways
QuickGOQ96K83
Ontology : AmiGODNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  protein domain specific binding  metal ion binding  neuron fate commitment  
Ontology : EGO-EBIDNA binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  protein domain specific binding  metal ion binding  neuron fate commitment  
NDEx NetworkZNF521
Atlas of Cancer Signalling NetworkZNF521
Wikipedia pathwaysZNF521
Orthology - Evolution
OrthoDB25925
GeneTree (enSembl)ENSG00000198795
Phylogenetic Trees/Animal Genes : TreeFamZNF521
HOVERGENQ96K83
HOGENOMQ96K83
Homologs : HomoloGeneZNF521
Homology/Alignments : Family Browser (UCSC)ZNF521
Gene fusions - Rearrangements
Fusion : MitelmanDTNA/ZNF521 [18q12.1/18q11.2]  [t(18;18)(q11;q12)]  
Fusion : MitelmanLAMA3/ZNF521 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanPARD3/ZNF521 [10p11.22/18q11.2]  [t(10;18)(p11;q11)]  
Fusion : MitelmanPAX5/ZNF521 [9p13.2/18q11.2]  [t(9;18)(p13;q11)]  
Fusion: TCGADTNA 18q12.1 ZNF521 18q11.2 BRCA
Fusion: TCGALAMA3 18q11.2 ZNF521 18q11.2 LUAD
Fusion: TCGAPARD3 10p11.22 ZNF521 18q11.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF521 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF521
dbVarZNF521
ClinVarZNF521
1000_GenomesZNF521 
Exome Variant ServerZNF521
ExAC (Exome Aggregation Consortium)ZNF521 (select the gene name)
Genetic variants : HAPMAP25925
Genomic Variants (DGV)ZNF521 [DGVbeta]
DECIPHERZNF521 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF521 
Mutations
ICGC Data PortalZNF521 
TCGA Data PortalZNF521 
Broad Tumor PortalZNF521
OASIS PortalZNF521 [ Somatic mutations - Copy number]
Cancer Gene: CensusZNF521 
Somatic Mutations in Cancer : COSMICZNF521  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF521
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF521
DgiDB (Drug Gene Interaction Database)ZNF521
DoCM (Curated mutations)ZNF521 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF521 (select a term)
intoGenZNF521
Cancer3DZNF521(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610974   
Orphanet
MedgenZNF521
Genetic Testing Registry ZNF521
NextProtQ96K83 [Medical]
TSGene25925
GENETestsZNF521
Target ValidationZNF521
Huge Navigator ZNF521 [HugePedia]
snp3D : Map Gene to Disease25925
BioCentury BCIQZNF521
ClinGenZNF521
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25925
Chemical/Pharm GKB GenePA134956321
Clinical trialZNF521
Miscellaneous
canSAR (ICR)ZNF521 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF521
EVEXZNF521
GoPubMedZNF521
iHOPZNF521
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:03:50 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.