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ZNF598 (zinc finger protein 598, E3 ubiquitin ligase)

Identity

Alias (NCBI)HEL2
HGNC (Hugo) ZNF598
HGNC Alias symbFLJ00086
LocusID (NCBI) 90850
Atlas_Id 76272
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1997654 and ends at 2009821 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF598 (16p13.3) / C16orf62 (16p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ZNF598   28079
Cards
Entrez_Gene (NCBI)ZNF598    zinc finger protein 598, E3 ubiquitin ligase
AliasesHEL2
GeneCards (Weizmann)ZNF598
Ensembl hg19 (Hinxton)ENSG00000167962 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167962 [Gene_View]  ENSG00000167962 [Sequence]  chr16:1997654-2009821 [Contig_View]  ZNF598 [Vega]
ICGC DataPortalENSG00000167962
TCGA cBioPortalZNF598
AceView (NCBI)ZNF598
Genatlas (Paris)ZNF598
SOURCE (Princeton)ZNF598
Genetics Home Reference (NIH)ZNF598
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF598  -     chr16:1997654-2009821 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF598  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathZNF598 - 16p13.3 [CytoView hg19]  ZNF598 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000167962
Genome Data Viewer NCBIZNF598 [Mapview hg19]  
OMIM617508   
Gene and transcription
Genbank (Entrez)AK024487 AL834428 BC010990 BC029270 BC041015
RefSeq transcript (Entrez)NM_178167
Consensus coding sequences : CCDS (NCBI)ZNF598
Gene ExpressionZNF598 [ NCBI-GEO ]   ZNF598 [ EBI - ARRAY_EXPRESS ]   ZNF598 [ SEEK ]   ZNF598 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF598 [ Firebrowse - Broad ]
GenevisibleExpression of ZNF598 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90850
GTEX Portal (Tissue expression)ZNF598
Human Protein AtlasENSG00000167962-ZNF598 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UK7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UK7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UK7
PhosPhoSitePlusQ86UK7
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)RING-HC_ZNF598/Hel2    Znf_C2H2_type    Znf_RING   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF598
SuperfamilyQ86UK7
AlphaFold pdb e-kbQ86UK7   
Human Protein Atlas [tissue]ENSG00000167962-ZNF598 [tissue]
HPRD11732
Protein Interaction databases
DIP (DOE-UCLA)Q86UK7
IntAct (EBI)Q86UK7
BioGRIDZNF598
STRING (EMBL)ZNF598
ZODIACZNF598
Ontologies - Pathways
QuickGOQ86UK7
Ontology : AmiGORNA binding  protein binding  protein monoubiquitination  protein ubiquitination  ribosome binding  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  rescue of stalled ribosome  rescue of stalled ribosome  
Ontology : EGO-EBIRNA binding  protein binding  protein monoubiquitination  protein ubiquitination  ribosome binding  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  rescue of stalled ribosome  rescue of stalled ribosome  
NDEx NetworkZNF598
Atlas of Cancer Signalling NetworkZNF598
Wikipedia pathwaysZNF598
Orthology - Evolution
OrthoDB90850
GeneTree (enSembl)ENSG00000167962
Phylogenetic Trees/Animal Genes : TreeFamZNF598
Homologs : HomoloGeneZNF598
Homology/Alignments : Family Browser (UCSC)ZNF598
Gene fusions - Rearrangements
Fusion : QuiverZNF598
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF598 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF598
dbVarZNF598
ClinVarZNF598
MonarchZNF598
1000_GenomesZNF598 
Exome Variant ServerZNF598
GNOMAD BrowserENSG00000167962
Varsome BrowserZNF598
ACMGZNF598 variants
VarityQ86UK7
Genomic Variants (DGV)ZNF598 [DGVbeta]
DECIPHERZNF598 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF598 
Mutations
ICGC Data PortalZNF598 
TCGA Data PortalZNF598 
Broad Tumor PortalZNF598
OASIS PortalZNF598 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF598  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZNF598
Mutations and Diseases : HGMDZNF598
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZNF598
DgiDB (Drug Gene Interaction Database)ZNF598
DoCM (Curated mutations)ZNF598
CIViC (Clinical Interpretations of Variants in Cancer)ZNF598
Cancer3DZNF598
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617508   
Orphanet
DisGeNETZNF598
MedgenZNF598
Genetic Testing Registry ZNF598
NextProtQ86UK7 [Medical]
GENETestsZNF598
Target ValidationZNF598
Huge Navigator ZNF598 [HugePedia]
ClinGenZNF598
Clinical trials, drugs, therapy
MyCancerGenomeZNF598
Protein Interactions : CTDZNF598
Pharm GKB GenePA134944505
PharosQ86UK7
Clinical trialZNF598
Miscellaneous
canSAR (ICR)ZNF598
HarmonizomeZNF598
DataMed IndexZNF598
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZNF598
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:30:04 CEST 2021

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