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ZNF638 (zinc finger protein 638)

Identity

Alias_namesZFML
zinc finger
Alias_symbol (synonym)NP220
MGC26130
Zfp638
Other alias
HGNC (Hugo) ZNF638
LocusID (NCBI) 27332
Atlas_Id 54812
Location 2p13.2  [Link to chromosome band 2p13]
Location_base_pair Starts at 71331755 and ends at 71435061 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC5L (6p21.1) / ZNF638 (2p13.2)DYSF (2p13.2) / ZNF638 (2p13.2)E2F8 (11p15.1) / ZNF638 (2p13.2)
MAPK1 (22q11.21) / ZNF638 (2p13.2)USP34 (2p15) / ZNF638 (2p13.2)ZNF638 (2p13.2) / C2orf74 (2p15)
ZNF638 (2p13.2) / C2orf78 (2p13.1)ZNF638 (2p13.2) / COL9A1 (6q13)ZNF638 (2p13.2) / EXOC6B (2p13.2)
ZNF638 (2p13.2) / GAPDH (12p13.31)ZNF638 (2p13.2) / KAZN (1p36.21)ZNF638 (2p13.2) / PHACTR1 (6p24.1)
ZNF638 (2p13.2) / RAX (18q21.32)ZNF638 (2p13.2) / ZNF638 (2p13.2)USP34 2p15 / ZNF638 2p13.2
ZNF638 2p13.2 / C2orf74 2p15ZNF638 2p13.2 / C2orf78 2p13.1ZNF638 2p13.2 / EXOC6B 2p13.2
ZNF638 2p13.2 / PHACTR1 6p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  ZNF638/C2orf78 (2p13)
ZNF638/EXOC6B (2p13)
t(2;2)(p13;p15) USP34/ZNF638
t(2;2)(p13;p15) ZNF638/C2orf74
t(2;6)(p13;p24) ZNF638/PHACTR1

External links

Nomenclature
HGNC (Hugo)ZNF638   17894
Cards
Entrez_Gene (NCBI)ZNF638  27332  zinc finger protein 638
AliasesNP220; ZFML; Zfp638
GeneCards (Weizmann)ZNF638
Ensembl hg19 (Hinxton)ENSG00000075292 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075292 [Gene_View]  ENSG00000075292 [Sequence]  chr2:71331755-71435061 [Contig_View]  ZNF638 [Vega]
ICGC DataPortalENSG00000075292
TCGA cBioPortalZNF638
AceView (NCBI)ZNF638
Genatlas (Paris)ZNF638
WikiGenes27332
SOURCE (Princeton)ZNF638
Genetics Home Reference (NIH)ZNF638
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF638  -     chr2:71331755-71435061 +  2p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF638  -     2p13.2   [Description]    (hg19-Feb_2009)
EnsemblZNF638 - 2p13.2 [CytoView hg19]  ZNF638 - 2p13.2 [CytoView hg38]
Mapping of homologs : NCBIZNF638 [Mapview hg19]  ZNF638 [Mapview hg38]
OMIM614349   
Gene and transcription
Genbank (Entrez)AF273049 AF534078 AI357871 AK093578 AK098006
RefSeq transcript (Entrez)NM_001014972 NM_001252612 NM_001252613 NM_014497
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF638
Cluster EST : UnigeneHs.732823 [ NCBI ]
CGAP (NCI)Hs.732823
Alternative Splicing GalleryENSG00000075292
Gene ExpressionZNF638 [ NCBI-GEO ]   ZNF638 [ EBI - ARRAY_EXPRESS ]   ZNF638 [ SEEK ]   ZNF638 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF638 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27332
GTEX Portal (Tissue expression)ZNF638
Human Protein AtlasENSG00000075292-ZNF638 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14966   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14966  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14966
Splice isoforms : SwissVarQ14966
PhosPhoSitePlusQ14966
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_MATRIN (PS50171)   
Domains : Interpro (EBI)Matrin/U1-C_Znf_C2H2    Matrin/U1-like-C_Znf_C2H2    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    ZNF638    Znf_C2H2_jaz    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-C2H2_jaz (PF12171)   
Domain families : Pfam (NCBI)pfam00076    pfam12171   
Domain families : Smart (EMBL)RRM (SM00360)  ZnF_C2H2 (SM00355)  ZnF_U1 (SM00451)  
Conserved Domain (NCBI)ZNF638
DMDM Disease mutations27332
Blocks (Seattle)ZNF638
SuperfamilyQ14966
Human Protein Atlas [tissue]ENSG00000075292-ZNF638 [tissue]
Peptide AtlasQ14966
HPRD11736
IPIIPI00470596   IPI00916798   IPI00607784   IPI00178953   IPI00607679   IPI00607883   IPI01011544   IPI00982459   IPI00917009   IPI00917159   IPI00917289   
Protein Interaction databases
DIP (DOE-UCLA)Q14966
IntAct (EBI)Q14966
FunCoupENSG00000075292
BioGRIDZNF638
STRING (EMBL)ZNF638
ZODIACZNF638
Ontologies - Pathways
QuickGOQ14966
Ontology : AmiGOdouble-stranded DNA binding  RNA binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  RNA splicing  nuclear speck  intracellular membrane-bounded organelle  
Ontology : EGO-EBIdouble-stranded DNA binding  RNA binding  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  RNA splicing  nuclear speck  intracellular membrane-bounded organelle  
NDEx NetworkZNF638
Atlas of Cancer Signalling NetworkZNF638
Wikipedia pathwaysZNF638
Orthology - Evolution
OrthoDB27332
GeneTree (enSembl)ENSG00000075292
Phylogenetic Trees/Animal Genes : TreeFamZNF638
HOVERGENQ14966
HOGENOMQ14966
Homologs : HomoloGeneZNF638
Homology/Alignments : Family Browser (UCSC)ZNF638
Gene fusions - Rearrangements
Fusion : MitelmanUSP34/ZNF638 [2p15/2p13.2]  [t(2;2)(p13;p15)]  
Fusion : MitelmanZNF638/C2orf74 [2p13.2/2p15]  [t(2;2)(p13;p15)]  
Fusion : MitelmanZNF638/C2orf78 [2p13.2/2p13.1]  [t(2;2)(p13;p13)]  
Fusion : MitelmanZNF638/EXOC6B [2p13.2/2p13.2]  [t(2;2)(p13;p13)]  
Fusion : MitelmanZNF638/PHACTR1 [2p13.2/6p24.1]  [t(2;6)(p13;p24)]  
Fusion PortalUSP34 2p15 ZNF638 2p13.2 BRCA
Fusion PortalZNF638 2p13.2 C2orf74 2p15 LUAD
Fusion PortalZNF638 2p13.2 C2orf78 2p13.1 BLCA
Fusion PortalZNF638 2p13.2 EXOC6B 2p13.2 LGG
Fusion PortalZNF638 2p13.2 PHACTR1 6p24.1 LUAD
Fusion : QuiverZNF638
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF638 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF638
dbVarZNF638
ClinVarZNF638
1000_GenomesZNF638 
Exome Variant ServerZNF638
ExAC (Exome Aggregation Consortium)ENSG00000075292
GNOMAD BrowserENSG00000075292
Varsome BrowserZNF638
Genetic variants : HAPMAP27332
Genomic Variants (DGV)ZNF638 [DGVbeta]
DECIPHERZNF638 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF638 
Mutations
ICGC Data PortalZNF638 
TCGA Data PortalZNF638 
Broad Tumor PortalZNF638
OASIS PortalZNF638 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF638  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF638
intOGen PortalZNF638
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF638
DgiDB (Drug Gene Interaction Database)ZNF638
DoCM (Curated mutations)ZNF638 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF638 (select a term)
intoGenZNF638
Cancer3DZNF638(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614349   
Orphanet
DisGeNETZNF638
MedgenZNF638
Genetic Testing Registry ZNF638
NextProtQ14966 [Medical]
TSGene27332
GENETestsZNF638
Target ValidationZNF638
Huge Navigator ZNF638 [HugePedia]
snp3D : Map Gene to Disease27332
BioCentury BCIQZNF638
ClinGenZNF638
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27332
Chemical/Pharm GKB GenePA134983478
Clinical trialZNF638
Miscellaneous
canSAR (ICR)ZNF638 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF638
EVEXZNF638
GoPubMedZNF638
iHOPZNF638
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 12:03:12 CEST 2018
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