ZNF703 (zinc finger protein 703)

2011-03-01  

Identity

HGNC
LOCATION
8p11.23
LOCUSID
ALIAS
NLZ1,ZEPPO1,ZNF503L,ZPO1
FUSION GENES

Other Information

Locus ID:

NCBI: 80139
MIM: 617045
HGNC: 25883
Ensembl: ENSG00000183779

Variants:

dbSNP: 80139
ClinVar: 80139
TCGA: ENSG00000183779
COSMIC: ZNF703

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183779ENST00000331569Q9H7S9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
257429522015The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.57
213375212011ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.56
213285422011ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.48
193300262009Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.44
241560162013High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.15
244814602014ZNF703 acts as an oncogene that promotes progression in gastric cancer.15
239910382013Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.13
250176102014ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer.11
291763142017Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma.9
228868852013Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression.6

Citation

Dessen P

ZNF703 (zinc finger protein 703)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52134/znf703