Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZNF74 (zinc finger protein 74)

Identity

Alias_nameszinc finger protein 74 (Cos52)
Alias_symbol (synonym)Cos52
Zfp520
ZNF520
Other aliasCOS52
ZFP520
hZNF7
HGNC (Hugo) ZNF74
LocusID (NCBI) 7625
Atlas_Id 42883
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20394115 and ends at 20408463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KLHL22 (22q11.21) / ZNF74 (22q11.21)KLHL22 22q11.21 / ZNF74 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(22;22)(q11;q11) KLHL22/ZNF74

External links

Nomenclature
HGNC (Hugo)ZNF74   13144
Cards
Entrez_Gene (NCBI)ZNF74  7625  zinc finger protein 74
AliasesCOS52; ZFP520; ZNF520; hZNF7
GeneCards (Weizmann)ZNF74
Ensembl hg19 (Hinxton)ENSG00000185252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185252 [Gene_View]  ENSG00000185252 [Sequence]  chr22:20394115-20408463 [Contig_View]  ZNF74 [Vega]
ICGC DataPortalENSG00000185252
TCGA cBioPortalZNF74
AceView (NCBI)ZNF74
Genatlas (Paris)ZNF74
WikiGenes7625
SOURCE (Princeton)ZNF74
Genetics Home Reference (NIH)ZNF74
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF74  -     chr22:20394115-20408463 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF74  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblZNF74 - 22q11.21 [CytoView hg19]  ZNF74 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIZNF74 [Mapview hg19]  ZNF74 [Mapview hg38]
OMIM194548   
Gene and transcription
Genbank (Entrez)AB209663 AK128267 AK291358 AK299569 BC013395
RefSeq transcript (Entrez)NM_001256523 NM_001256524 NM_001256525 NM_003426
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF74
Cluster EST : UnigeneHs.517418 [ NCBI ]
CGAP (NCI)Hs.517418
Alternative Splicing GalleryENSG00000185252
Gene ExpressionZNF74 [ NCBI-GEO ]   ZNF74 [ EBI - ARRAY_EXPRESS ]   ZNF74 [ SEEK ]   ZNF74 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF74 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7625
GTEX Portal (Tissue expression)ZNF74
Human Protein AtlasENSG00000185252-ZNF74 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16587   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16587  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16587
Splice isoforms : SwissVarQ16587
PhosPhoSitePlusQ16587
Domaine pattern : Prosite (Expaxy)KRAB (PS50805)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)KRAB    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)KRAB (PF01352)    zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam01352    pfam00096   
Domain families : Smart (EMBL)KRAB (SM00349)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF74
DMDM Disease mutations7625
Blocks (Seattle)ZNF74
SuperfamilyQ16587
Human Protein Atlas [tissue]ENSG00000185252-ZNF74 [tissue]
Peptide AtlasQ16587
HPRD01928
IPIIPI00220139   IPI00807386   IPI00220140   IPI00480138   IPI00893344   IPI00892733   IPI00892603   IPI00892864   
Protein Interaction databases
DIP (DOE-UCLA)Q16587
IntAct (EBI)Q16587
FunCoupENSG00000185252
BioGRIDZNF74
STRING (EMBL)ZNF74
ZODIACZNF74
Ontologies - Pathways
QuickGOQ16587
Ontology : AmiGODNA binding  DNA binding transcription factor activity  RNA binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organism development  actin cytoskeleton  metal ion binding  
Ontology : EGO-EBIDNA binding  DNA binding transcription factor activity  RNA binding  nucleoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organism development  actin cytoskeleton  metal ion binding  
NDEx NetworkZNF74
Atlas of Cancer Signalling NetworkZNF74
Wikipedia pathwaysZNF74
Orthology - Evolution
OrthoDB7625
GeneTree (enSembl)ENSG00000185252
Phylogenetic Trees/Animal Genes : TreeFamZNF74
HOVERGENQ16587
HOGENOMQ16587
Homologs : HomoloGeneZNF74
Homology/Alignments : Family Browser (UCSC)ZNF74
Gene fusions - Rearrangements
Fusion : MitelmanKLHL22/ZNF74 [22q11.21/22q11.21]  [t(22;22)(q11;q11)]  
Fusion PortalKLHL22 22q11.21 ZNF74 22q11.21 LUSC
Fusion : QuiverZNF74
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF74
dbVarZNF74
ClinVarZNF74
1000_GenomesZNF74 
Exome Variant ServerZNF74
ExAC (Exome Aggregation Consortium)ENSG00000185252
GNOMAD BrowserENSG00000185252
Genetic variants : HAPMAP7625
Genomic Variants (DGV)ZNF74 [DGVbeta]
DECIPHERZNF74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF74 
Mutations
ICGC Data PortalZNF74 
TCGA Data PortalZNF74 
Broad Tumor PortalZNF74
OASIS PortalZNF74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF74  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNF74
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF74
DgiDB (Drug Gene Interaction Database)ZNF74
DoCM (Curated mutations)ZNF74 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF74 (select a term)
intoGenZNF74
Cancer3DZNF74(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194548   
Orphanet
DisGeNETZNF74
MedgenZNF74
Genetic Testing Registry ZNF74
NextProtQ16587 [Medical]
TSGene7625
GENETestsZNF74
Target ValidationZNF74
Huge Navigator ZNF74 [HugePedia]
snp3D : Map Gene to Disease7625
BioCentury BCIQZNF74
ClinGenZNF74
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7625
Chemical/Pharm GKB GenePA37718
Clinical trialZNF74
Miscellaneous
canSAR (ICR)ZNF74 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF74
EVEXZNF74
GoPubMedZNF74
iHOPZNF74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:58:45 CEST 2018
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