Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ZNFX1 (zinc finger NFX1-type containing 1)

Identity

Alias_nameszinc finger
Alias_symbol (synonym)KIAA1404
FLJ11277
Other alias-
HGNC (Hugo) ZNFX1
LocusID (NCBI) 57169
Atlas_Id 46397
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49245901 and ends at 49278219 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHNAK (11q12.3) / ZNFX1 (20q13.13)CSDE1 (1p13.2) / ZNFX1 (20q13.13)CTNND1 (11q12.1) / ZNFX1 (20q13.13)
EIF4G2 (11p15.3) / ZNFX1 (20q13.13)FXYD3 (19q13.12) / ZNFX1 (20q13.13)MYL6 (12q13.2) / ZNFX1 (20q13.13)
P4HB (17q25.3) / ZNFX1 (20q13.13)PSMA3 (14q23.1) / ZNFX1 (20q13.13)SERINC2 (1p35.2) / ZNFX1 (20q13.13)
TALDO1 (11p15.5) / ZNFX1 (20q13.13)TIMP3 (22q12.3) / ZNFX1 (20q13.13)ZNFX1 (20q13.13) / CCDC181 (1q24.2)
ZNFX1 (20q13.13) / CNBD2 (20q11.23)ZNFX1 (20q13.13) / MPO (17q22)ZNFX1 (20q13.13) / ZNFX1 (20q13.13)
AHNAK 11q12.3 / ZNFX1 20q13.13CTNND1 11q12.1 / ZNFX1 20q13.13EIF4G2 11p15.3 / ZNFX1 20q13.13
FXYD3 19q13.12 / ZNFX1 20q13.13MYL6 12q13.2 / ZNFX1 20q13.13P4HB 17q25.3 / ZNFX1 20q13.13
PSMA3 14q23.1 / ZNFX1 20q13.13SERINC2 1p35.2 / ZNFX1 20q13.13TALDO1 11p15.5 / ZNFX1 20q13.13
TIMP3 22q12.3 / ZNFX1 20q13.13ZNFX1 20q13.13 C20orf152

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ]
  t(1;20)(p35;q13) SERINC2/ZNFX1
t(11;20)(p15;q13) EIF4G2/ZNFX1
t(11;20)(p15;q13) TALDO1/ZNFX1
t(11;20)(q12;q13) AHNAK/ZNFX1
t(11;20)(q12;q13) CTNND1/ZNFX1
t(12;20)(q13;q13) MYL6/ZNFX1
t(14;20)(q23;q13) PSMA3/ZNFX1
t(17;20)(q25;q13) P4HB/ZNFX1
t(19;20)(q13;q13) FXYD3/ZNFX1
t(20;20)(p11;q13) RALGAPA2/ZNFX1
t(20;20)(q11;q13) ZNFX1/CNBD2
t(20;22)(q13;q12) TIMP3/ZNFX1

External links

Nomenclature
HGNC (Hugo)ZNFX1   29271
Cards
Entrez_Gene (NCBI)ZNFX1  57169  zinc finger NFX1-type containing 1
Aliases
GeneCards (Weizmann)ZNFX1
Ensembl hg19 (Hinxton)ENSG00000124201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124201 [Gene_View]  ENSG00000124201 [Sequence]  chr20:49245901-49278219 [Contig_View]  ZNFX1 [Vega]
ICGC DataPortalENSG00000124201
TCGA cBioPortalZNFX1
AceView (NCBI)ZNFX1
Genatlas (Paris)ZNFX1
WikiGenes57169
SOURCE (Princeton)ZNFX1
Genetics Home Reference (NIH)ZNFX1
Genomic and cartography
GoldenPath hg38 (UCSC)ZNFX1  -     chr20:49245901-49278219 -  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNFX1  -     20q13.13   [Description]    (hg19-Feb_2009)
GoldenPathZNFX1 - 20q13.13 [CytoView hg19]  ZNFX1 - 20q13.13 [CytoView hg38]
ImmunoBaseENSG00000124201
Mapping of homologs : NCBIZNFX1 [Mapview hg19]  ZNFX1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB037825 AK000573 AK002139 AK022641 AK023836
RefSeq transcript (Entrez)NM_021035
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNFX1
Cluster EST : UnigeneHs.371794 [ NCBI ]
CGAP (NCI)Hs.371794
Alternative Splicing GalleryENSG00000124201
Gene ExpressionZNFX1 [ NCBI-GEO ]   ZNFX1 [ EBI - ARRAY_EXPRESS ]   ZNFX1 [ SEEK ]   ZNFX1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNFX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57169
GTEX Portal (Tissue expression)ZNFX1
Human Protein AtlasENSG00000124201-ZNFX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2E3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2E3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2E3
Splice isoforms : SwissVarQ9P2E3
PhosPhoSitePlusQ9P2E3
Domains : Interpro (EBI)ARM-type_fold    P-loop_NTPase    Znf_NFX1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_NFX (SM00438)  
Conserved Domain (NCBI)ZNFX1
DMDM Disease mutations57169
Blocks (Seattle)ZNFX1
SuperfamilyQ9P2E3
Human Protein Atlas [tissue]ENSG00000124201-ZNFX1 [tissue]
Peptide AtlasQ9P2E3
HPRD11142
IPIIPI00165981   IPI00979116   IPI00645098   IPI00645570   IPI00220462   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2E3
IntAct (EBI)Q9P2E3
FunCoupENSG00000124201
BioGRIDZNFX1
STRING (EMBL)ZNFX1
ZODIACZNFX1
Ontologies - Pathways
QuickGOQ9P2E3
Ontology : AmiGOchromosome, centromeric region  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA binding  RNA binding  nucleus  regulation of transcription by RNA polymerase II  zinc ion binding  chromatin silencing at centromere  chromatin silencing by small RNA  nuclear RNA-directed RNA polymerase complex  
Ontology : EGO-EBIchromosome, centromeric region  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA binding  RNA binding  nucleus  regulation of transcription by RNA polymerase II  zinc ion binding  chromatin silencing at centromere  chromatin silencing by small RNA  nuclear RNA-directed RNA polymerase complex  
NDEx NetworkZNFX1
Atlas of Cancer Signalling NetworkZNFX1
Wikipedia pathwaysZNFX1
Orthology - Evolution
OrthoDB57169
GeneTree (enSembl)ENSG00000124201
Phylogenetic Trees/Animal Genes : TreeFamZNFX1
HOGENOMQ9P2E3
Homologs : HomoloGeneZNFX1
Homology/Alignments : Family Browser (UCSC)ZNFX1
Gene fusions - Rearrangements
Fusion : MitelmanAHNAK/ZNFX1 [11q12.3/20q13.13]  [t(11;20)(q12;q13)]  
Fusion : MitelmanCTNND1/ZNFX1 [11q12.1/20q13.13]  [t(11;20)(q12;q13)]  
Fusion : MitelmanEIF4G2/ZNFX1 [11p15.3/20q13.13]  [t(11;20)(p15;q13)]  
Fusion : MitelmanFXYD3/ZNFX1 [19q13.12/20q13.13]  [t(19;20)(q13;q13)]  
Fusion : MitelmanMYL6/ZNFX1 [12q13.2/20q13.13]  [t(12;20)(q13;q13)]  
Fusion : MitelmanP4HB/ZNFX1 [17q25.3/20q13.13]  [t(17;20)(q25;q13)]  
Fusion : MitelmanPSMA3/ZNFX1 [14q23.1/20q13.13]  [t(14;20)(q23;q13)]  
Fusion : MitelmanSERINC2/ZNFX1 [1p35.2/20q13.13]  [t(1;20)(p35;q13)]  
Fusion : MitelmanTALDO1/ZNFX1 [11p15.5/20q13.13]  [t(11;20)(p15;q13)]  
Fusion : MitelmanTIMP3/ZNFX1 [22q12.3/20q13.13]  [t(20;22)(q13;q12)]  
Fusion : MitelmanZNFX1/CNBD2 [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion PortalAHNAK 11q12.3 ZNFX1 20q13.13 PRAD
Fusion PortalCTNND1 11q12.1 ZNFX1 20q13.13 BLCA
Fusion PortalEIF4G2 11p15.3 ZNFX1 20q13.13 LUAD
Fusion PortalFXYD3 19q13.12 ZNFX1 20q13.13 BLCA
Fusion PortalMYL6 12q13.2 ZNFX1 20q13.13 BLCA HNSC
Fusion PortalP4HB 17q25.3 ZNFX1 20q13.13 BLCA
Fusion PortalPSMA3 14q23.1 ZNFX1 20q13.13 BRCA
Fusion PortalSERINC2 1p35.2 ZNFX1 20q13.13 LUAD
Fusion PortalTALDO1 11p15.5 ZNFX1 20q13.13 LUAD
Fusion PortalTIMP3 22q12.3 ZNFX1 20q13.13 SKCM
Fusion PortalZNFX1 20q13.13 C20orf152 BRCA
Fusion : QuiverZNFX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNFX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNFX1
dbVarZNFX1
ClinVarZNFX1
1000_GenomesZNFX1 
Exome Variant ServerZNFX1
ExAC (Exome Aggregation Consortium)ENSG00000124201
GNOMAD BrowserENSG00000124201
Varsome BrowserZNFX1
Genetic variants : HAPMAP57169
Genomic Variants (DGV)ZNFX1 [DGVbeta]
DECIPHERZNFX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNFX1 
Mutations
ICGC Data PortalZNFX1 
TCGA Data PortalZNFX1 
Broad Tumor PortalZNFX1
OASIS PortalZNFX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNFX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNFX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNFX1
DgiDB (Drug Gene Interaction Database)ZNFX1
DoCM (Curated mutations)ZNFX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNFX1 (select a term)
intoGenZNFX1
Cancer3DZNFX1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETZNFX1
MedgenZNFX1
Genetic Testing Registry ZNFX1
NextProtQ9P2E3 [Medical]
TSGene57169
GENETestsZNFX1
Target ValidationZNFX1
Huge Navigator ZNFX1 [HugePedia]
snp3D : Map Gene to Disease57169
BioCentury BCIQZNFX1
ClinGenZNFX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57169
Chemical/Pharm GKB GenePA143485687
Clinical trialZNFX1
Miscellaneous
canSAR (ICR)ZNFX1 (select the gene name)
DataMed IndexZNFX1
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNFX1
EVEXZNFX1
GoPubMedZNFX1
iHOPZNFX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 8 11:48:55 CEST 2019
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.