Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZNRF1 (zinc and ring finger 1)

Identity

Alias_nameszinc and ring finger 1, E3 ubiquitin protein ligase
Alias_symbol (synonym)nin283
FLJ14846
DKFZp434E229
Other aliasNIN283
HGNC (Hugo) ZNRF1
LocusID (NCBI) 84937
Atlas_Id 76470
Location 16q23.1  [Link to chromosome band 16q23]
Location_base_pair Starts at 74999017 and ends at 75110994 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZNRF1 (16q23.1) / BCAS4 (20q13.13)ZNRF1 (16q23.1) / ELMO1 (7p14.2)ZNRF1 (16q23.1) / SPATS2L (2q33.1)
ZNRF1 (16q23.1) / ZNRF1 (16q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZNRF1   18452
Cards
Entrez_Gene (NCBI)ZNRF1  84937  zinc and ring finger 1
AliasesNIN283
GeneCards (Weizmann)ZNRF1
Ensembl hg19 (Hinxton)ENSG00000186187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186187 [Gene_View]  chr16:74999017-75110994 [Contig_View]  ZNRF1 [Vega]
ICGC DataPortalENSG00000186187
TCGA cBioPortalZNRF1
AceView (NCBI)ZNRF1
Genatlas (Paris)ZNRF1
WikiGenes84937
SOURCE (Princeton)ZNRF1
Genetics Home Reference (NIH)ZNRF1
Genomic and cartography
GoldenPath hg38 (UCSC)ZNRF1  -     chr16:74999017-75110994 +  16q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNRF1  -     16q23.1   [Description]    (hg19-Feb_2009)
EnsemblZNRF1 - 16q23.1 [CytoView hg19]  ZNRF1 - 16q23.1 [CytoView hg38]
Mapping of homologs : NCBIZNRF1 [Mapview hg19]  ZNRF1 [Mapview hg38]
OMIM612060   
Gene and transcription
Genbank (Entrez)AF378524 AK027752 AK094870 AK128349 AK294434
RefSeq transcript (Entrez)NM_032268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNRF1
Cluster EST : UnigeneHs.427284 [ NCBI ]
CGAP (NCI)Hs.427284
Alternative Splicing GalleryENSG00000186187
Gene ExpressionZNRF1 [ NCBI-GEO ]   ZNRF1 [ EBI - ARRAY_EXPRESS ]   ZNRF1 [ SEEK ]   ZNRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNRF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84937
GTEX Portal (Tissue expression)ZNRF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8ND25   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8ND25  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8ND25
Splice isoforms : SwissVarQ8ND25
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8ND25
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)ZNRF1
DMDM Disease mutations84937
Blocks (Seattle)ZNRF1
SuperfamilyQ8ND25
Human Protein AtlasENSG00000186187
Peptide AtlasQ8ND25
HPRD15893
IPIIPI00031059   IPI00168439   
Protein Interaction databases
DIP (DOE-UCLA)Q8ND25
IntAct (EBI)Q8ND25
FunCoupENSG00000186187
BioGRIDZNRF1
STRING (EMBL)ZNRF1
ZODIACZNRF1
Ontologies - Pathways
QuickGOQ8ND25
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  lysosome  endosome  cytosol  cytosol  zinc ion binding  membrane  cell junction  synaptic vesicle membrane  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  protein K48-linked ubiquitination  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  lysosome  endosome  cytosol  cytosol  zinc ion binding  membrane  cell junction  synaptic vesicle membrane  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  protein K48-linked ubiquitination  
NDEx NetworkZNRF1
Atlas of Cancer Signalling NetworkZNRF1
Wikipedia pathwaysZNRF1
Orthology - Evolution
OrthoDB84937
GeneTree (enSembl)ENSG00000186187
Phylogenetic Trees/Animal Genes : TreeFamZNRF1
HOVERGENQ8ND25
HOGENOMQ8ND25
Homologs : HomoloGeneZNRF1
Homology/Alignments : Family Browser (UCSC)ZNRF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNRF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNRF1
dbVarZNRF1
ClinVarZNRF1
1000_GenomesZNRF1 
Exome Variant ServerZNRF1
ExAC (Exome Aggregation Consortium)ZNRF1 (select the gene name)
Genetic variants : HAPMAP84937
Genomic Variants (DGV)ZNRF1 [DGVbeta]
DECIPHERZNRF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNRF1 
Mutations
ICGC Data PortalZNRF1 
TCGA Data PortalZNRF1 
Broad Tumor PortalZNRF1
OASIS PortalZNRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNRF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNRF1
DgiDB (Drug Gene Interaction Database)ZNRF1
DoCM (Curated mutations)ZNRF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNRF1 (select a term)
intoGenZNRF1
Cancer3DZNRF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612060   
Orphanet
MedgenZNRF1
Genetic Testing Registry ZNRF1
NextProtQ8ND25 [Medical]
TSGene84937
GENETestsZNRF1
Target ValidationZNRF1
Huge Navigator ZNRF1 [HugePedia]
snp3D : Map Gene to Disease84937
BioCentury BCIQZNRF1
ClinGenZNRF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84937
Chemical/Pharm GKB GenePA134938288
Clinical trialZNRF1
Miscellaneous
canSAR (ICR)ZNRF1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNRF1
EVEXZNRF1
GoPubMedZNRF1
iHOPZNRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:45:30 CEST 2017

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