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ZNRF2 (zinc and ring finger 2, E3 ubiquitin protein ligase)

Identity

Alias_nameszinc and ring finger 2, E3 ubiquitin protein ligase
Alias_symbol (synonym)RNF202
Other alias
HGNC (Hugo) ZNRF2
LocusID (NCBI) 223082
Atlas_Id 76471
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 30323923 and ends at 30407308 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MIR550A1 (7p14.3) / ZNRF2 (7p14.3)TNS3 (7p12.3) / ZNRF2 (7p14.3)TRPS1 (8q23.3) / ZNRF2 (7p14.3)
ZNRF2 (7p14.3) / MTURN (7p14.3)TRPS1 ZNRF2TNS3 ZNRF2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZNRF2   22316
Cards
Entrez_Gene (NCBI)ZNRF2  223082  zinc and ring finger 2, E3 ubiquitin protein ligase
AliasesRNF202
GeneCards (Weizmann)ZNRF2
Ensembl hg19 (Hinxton)ENSG00000180233 [Gene_View]  chr7:30323923-30407308 [Contig_View]  ZNRF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180233 [Gene_View]  chr7:30323923-30407308 [Contig_View]  ZNRF2 [Vega]
ICGC DataPortalENSG00000180233
TCGA cBioPortalZNRF2
AceView (NCBI)ZNRF2
Genatlas (Paris)ZNRF2
WikiGenes223082
SOURCE (Princeton)ZNRF2
Genetics Home Reference (NIH)ZNRF2
Genomic and cartography
GoldenPath hg19 (UCSC)ZNRF2  -     chr7:30323923-30407308 +  7p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZNRF2  -     7p14.3   [Description]    (hg38-Dec_2013)
EnsemblZNRF2 - 7p14.3 [CytoView hg19]  ZNRF2 - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBIZNRF2 [Mapview hg19]  ZNRF2 [Mapview hg38]
OMIM612061   
Gene and transcription
Genbank (Entrez)AF513707 AF527533 AK025240 AY054122 BC172400
RefSeq transcript (Entrez)NM_147128
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)ZNRF2
Cluster EST : UnigeneHs.263912 [ NCBI ]
CGAP (NCI)Hs.263912
Alternative Splicing GalleryENSG00000180233
Gene ExpressionZNRF2 [ NCBI-GEO ]   ZNRF2 [ EBI - ARRAY_EXPRESS ]   ZNRF2 [ SEEK ]   ZNRF2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNRF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)223082
GTEX Portal (Tissue expression)ZNRF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NHG8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NHG8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NHG8
Splice isoforms : SwissVarQ8NHG8
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ8NHG8
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)ZNRF2
DMDM Disease mutations223082
Blocks (Seattle)ZNRF2
SuperfamilyQ8NHG8
Human Protein AtlasENSG00000180233
Peptide AtlasQ8NHG8
HPRD15894
IPIIPI00293427   IPI00386194   
Protein Interaction databases
DIP (DOE-UCLA)Q8NHG8
IntAct (EBI)Q8NHG8
FunCoupENSG00000180233
BioGRIDZNRF2
STRING (EMBL)ZNRF2
ZODIACZNRF2
Ontologies - Pathways
QuickGOQ8NHG8
Ontology : AmiGOcytoplasm  lysosomal membrane  plasma membrane  zinc ion binding  endosome membrane  protein ubiquitination  ligase activity  cell junction  cytoplasmic vesicle membrane  presynaptic membrane  protein complex  ubiquitin protein ligase activity  
Ontology : EGO-EBIcytoplasm  lysosomal membrane  plasma membrane  zinc ion binding  endosome membrane  protein ubiquitination  ligase activity  cell junction  cytoplasmic vesicle membrane  presynaptic membrane  protein complex  ubiquitin protein ligase activity  
NDEx NetworkZNRF2
Atlas of Cancer Signalling NetworkZNRF2
Wikipedia pathwaysZNRF2
Orthology - Evolution
OrthoDB223082
GeneTree (enSembl)ENSG00000180233
Phylogenetic Trees/Animal Genes : TreeFamZNRF2
HOVERGENQ8NHG8
HOGENOMQ8NHG8
Homologs : HomoloGeneZNRF2
Homology/Alignments : Family Browser (UCSC)ZNRF2
Gene fusions - Rearrangements
Fusion: TCGATRPS1 ZNRF2
Fusion: TCGATNS3 ZNRF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNRF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNRF2
dbVarZNRF2
ClinVarZNRF2
1000_GenomesZNRF2 
Exome Variant ServerZNRF2
ExAC (Exome Aggregation Consortium)ZNRF2 (select the gene name)
Genetic variants : HAPMAP223082
Genomic Variants (DGV)ZNRF2 [DGVbeta]
DECIPHER (Syndromes)7:30323923-30407308  ENSG00000180233
CONAN: Copy Number AnalysisZNRF2 
Mutations
ICGC Data PortalZNRF2 
TCGA Data PortalZNRF2 
Broad Tumor PortalZNRF2
OASIS PortalZNRF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNRF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNRF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNRF2
DgiDB (Drug Gene Interaction Database)ZNRF2
DoCM (Curated mutations)ZNRF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNRF2 (select a term)
intoGenZNRF2
Cancer3DZNRF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612061   
Orphanet
MedgenZNRF2
Genetic Testing Registry ZNRF2
NextProtQ8NHG8 [Medical]
TSGene223082
GENETestsZNRF2
Huge Navigator ZNRF2 [HugePedia]
snp3D : Map Gene to Disease223082
BioCentury BCIQZNRF2
ClinGenZNRF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD223082
Chemical/Pharm GKB GenePA134961488
Clinical trialZNRF2
Miscellaneous
canSAR (ICR)ZNRF2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNRF2
EVEXZNRF2
GoPubMedZNRF2
iHOPZNRF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:54:09 CET 2017

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