Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZNRF3 (zinc and ring finger 3)

Identity

Alias_symbol (synonym)KIAA1133
BK747E2.3
FLJ22057
RNF203
Other alias
HGNC (Hugo) ZNRF3
LocusID (NCBI) 84133
Atlas_Id 53896
Location 22q12.1  [Link to chromosome band 22q12]
Location_base_pair Starts at 29279755 and ends at 29453476 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASH1L (1q22) / ZNRF3 (22q12.1)DNAAF5 (7p22.3) / ZNRF3 (22q12.1)ERG (21q22.2) / ZNRF3 (22q12.1)
ZNRF3 (22q12.1) / ASCC2 (22q12.2)ZNRF3 (22q12.1) / MED15 (22q11.21)ZNRF3 (22q12.1) / XBP1 (22q12.1)
ZNRF3 (22q12.1) / ZNRF3 (22q12.1)ERG 21q22.2 / ZNRF3 22q12.1HEATR2 ZNRF3 22q12.1
ZNRF3 22q12.1 / ASCC2 22q12.2ZNRF3 22q12.1 / MED15 22q11.21ZNRF3 22q12.1 / XBP1 22q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZNRF3   18126
Cards
Entrez_Gene (NCBI)ZNRF3  84133  zinc and ring finger 3
AliasesBK747E2.3; RNF203
GeneCards (Weizmann)ZNRF3
Ensembl hg19 (Hinxton)ENSG00000183579 [Gene_View]  chr22:29279755-29453476 [Contig_View]  ZNRF3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000183579 [Gene_View]  chr22:29279755-29453476 [Contig_View]  ZNRF3 [Vega]
ICGC DataPortalENSG00000183579
TCGA cBioPortalZNRF3
AceView (NCBI)ZNRF3
Genatlas (Paris)ZNRF3
WikiGenes84133
SOURCE (Princeton)ZNRF3
Genetics Home Reference (NIH)ZNRF3
Genomic and cartography
GoldenPath hg19 (UCSC)ZNRF3  -     chr22:29279755-29453476 +  22q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZNRF3  -     22q12.1   [Description]    (hg38-Dec_2013)
EnsemblZNRF3 - 22q12.1 [CytoView hg19]  ZNRF3 - 22q12.1 [CytoView hg38]
Mapping of homologs : NCBIZNRF3 [Mapview hg19]  ZNRF3 [Mapview hg38]
OMIM612062   
Gene and transcription
Genbank (Entrez)AB051436 AI244417 AK022809 AK025710 AK096397
RefSeq transcript (Entrez)NM_001206998 NM_032173
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)ZNRF3
Cluster EST : UnigeneHs.732114 [ NCBI ]
CGAP (NCI)Hs.732114
Alternative Splicing GalleryENSG00000183579
Gene ExpressionZNRF3 [ NCBI-GEO ]   ZNRF3 [ EBI - ARRAY_EXPRESS ]   ZNRF3 [ SEEK ]   ZNRF3 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNRF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84133
GTEX Portal (Tissue expression)ZNRF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULT6
Splice isoforms : SwissVarQ9ULT6
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9ULT6
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)ZNRF3
DMDM Disease mutations84133
Blocks (Seattle)ZNRF3
SuperfamilyQ9ULT6
Human Protein AtlasENSG00000183579
Peptide AtlasQ9ULT6
IPIIPI00853368   IPI01014235   IPI01011789   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULT6
IntAct (EBI)Q9ULT6
FunCoupENSG00000183579
BioGRIDZNRF3
STRING (EMBL)ZNRF3
ZODIACZNRF3
Ontologies - Pathways
QuickGOQ9ULT6
Ontology : AmiGOubiquitin-protein transferase activity  frizzled binding  protein binding  plasma membrane  integral component of plasma membrane  ubiquitin-dependent protein catabolic process  zinc ion binding  protein ubiquitination  protein ubiquitination  ligase activity  Wnt receptor catabolic process  Wnt receptor catabolic process  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  ubiquitin protein ligase activity  stem cell proliferation  negative regulation of canonical Wnt signaling pathway  negative regulation of non-canonical Wnt signaling pathway  
Ontology : EGO-EBIubiquitin-protein transferase activity  frizzled binding  protein binding  plasma membrane  integral component of plasma membrane  ubiquitin-dependent protein catabolic process  zinc ion binding  protein ubiquitination  protein ubiquitination  ligase activity  Wnt receptor catabolic process  Wnt receptor catabolic process  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  ubiquitin protein ligase activity  stem cell proliferation  negative regulation of canonical Wnt signaling pathway  negative regulation of non-canonical Wnt signaling pathway  
NDEx NetworkZNRF3
Atlas of Cancer Signalling NetworkZNRF3
Wikipedia pathwaysZNRF3
Orthology - Evolution
OrthoDB84133
GeneTree (enSembl)ENSG00000183579
Phylogenetic Trees/Animal Genes : TreeFamZNRF3
HOVERGENQ9ULT6
HOGENOMQ9ULT6
Homologs : HomoloGeneZNRF3
Homology/Alignments : Family Browser (UCSC)ZNRF3
Gene fusions - Rearrangements
Fusion : MitelmanDNAAF5/ZNRF3 [7p22.3/22q12.1]  [t(7;22)(p22;q12)]  
Fusion : MitelmanERG/ZNRF3 [21q22.2/22q12.1]  [t(21;22)(q22;q12)]  
Fusion : MitelmanZNRF3/ASCC2 [22q12.1/22q12.2]  [t(22;22)(q12;q12)]  
Fusion : MitelmanZNRF3/MED15 [22q12.1/22q11.21]  [t(22;22)(q11;q12)]  
Fusion : MitelmanZNRF3/XBP1 [22q12.1/22q12.1]  [t(22;22)(q12;q12)]  
Fusion: TCGAERG 21q22.2 ZNRF3 22q12.1 PRAD
Fusion: TCGAHEATR2 ZNRF3 22q12.1 BLCA
Fusion: TCGAZNRF3 22q12.1 ASCC2 22q12.2 BRCA
Fusion: TCGAZNRF3 22q12.1 MED15 22q11.21 LUSC
Fusion: TCGAZNRF3 22q12.1 XBP1 22q12.1 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNRF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNRF3
dbVarZNRF3
ClinVarZNRF3
1000_GenomesZNRF3 
Exome Variant ServerZNRF3
ExAC (Exome Aggregation Consortium)ZNRF3 (select the gene name)
Genetic variants : HAPMAP84133
Genomic Variants (DGV)ZNRF3 [DGVbeta]
DECIPHER (Syndromes)22:29279755-29453476  ENSG00000183579
CONAN: Copy Number AnalysisZNRF3 
Mutations
ICGC Data PortalZNRF3 
TCGA Data PortalZNRF3 
Broad Tumor PortalZNRF3
OASIS PortalZNRF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNRF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZNRF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNRF3
DgiDB (Drug Gene Interaction Database)ZNRF3
DoCM (Curated mutations)ZNRF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNRF3 (select a term)
intoGenZNRF3
Cancer3DZNRF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612062   
Orphanet
MedgenZNRF3
Genetic Testing Registry ZNRF3
NextProtQ9ULT6 [Medical]
TSGene84133
GENETestsZNRF3
Huge Navigator ZNRF3 [HugePedia]
snp3D : Map Gene to Disease84133
BioCentury BCIQZNRF3
ClinGenZNRF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84133
Chemical/Pharm GKB GenePA134983897
Clinical trialZNRF3
Miscellaneous
canSAR (ICR)ZNRF3 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNRF3
EVEXZNRF3
GoPubMedZNRF3
iHOPZNRF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:35:17 CET 2017

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