ZP2 (zona pellucida glycoprotein 2)

2014-11-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
OOMD6,ZPA,Zp-2

Other Information

Locus ID:

NCBI: 7783
MIM: 182888
HGNC: 13188
Ensembl: ENSG00000103310

Variants:

dbSNP: 7783
ClinVar: 7783
TCGA: ENSG00000103310
COSMIC: ZP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103310ENST00000574002Q05996
ENSG00000103310ENST00000574091Q05996

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Interaction With The Zona PellucidaREACTOMER-HSA-1300644

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249341542014A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans.29
164075012006Biological effects of recombinant human zona pellucida proteins on sperm function.12
234174052012Influence of the zona pellucida of the mouse egg on folliculogenesis and fertility.12
180338062008Detection of zona pellucida proteins during human folliculogenesis.9
286464522017Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.9
228894932012Genetic and physiological study of morphologically abnormal human zona pellucida.6
308108692019Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation.6
159506512005Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC.5
298958522019ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.5

Citation

Dessen P

ZP2 (zona pellucida glycoprotein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/76476/zp2