ZP3 (zona pellucida glycoprotein 3)

2016-10-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
OOMD3,ZP3A,ZP3B,ZPC,Zp-3
FUSION GENES

Other Information

Locus ID:

NCBI: 7784
MIM: 182889
HGNC: 13189
Ensembl: ENSG00000188372

Variants:

dbSNP: 7784
ClinVar: 7784
TCGA: ENSG00000188372
COSMIC: ZP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188372ENST00000336517P21754
ENSG00000188372ENST00000394857P21754
ENSG00000188372ENST00000394860H0Y3M4
ENSG00000188372ENST00000416245E9PFI9

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Interaction With The Zona PellucidaREACTOMER-HSA-1300644

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
186677502008Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa.17
146730922003Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans.15
164075012006Biological effects of recombinant human zona pellucida proteins on sperm function.12
180338062008Detection of zona pellucida proteins during human folliculogenesis.9
286464522017Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.9
243342452014Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3.7
153795482004Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.6
192463202009Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus.6
228894932012Genetic and physiological study of morphologically abnormal human zona pellucida.6

Citation

Dessen P

ZP3 (zona pellucida glycoprotein 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56382/zp3