Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ZP3 (zona pellucida glycoprotein 3)

Identity

Alias_namesZP3A
ZP3B
zona pellucida glycoprotein 3A (sperm receptor)
Alias_symbol (synonym)ZP3-424
ZP3-372
ZPC
Other aliasOOMD3
Zp-3
HGNC (Hugo) ZP3
LocusID (NCBI) 7784
Atlas_Id 56382
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 76397524 and ends at 76442071 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAZ1B (7q11.23) / ZP3 (7q11.23)DEF6 (6p21.31) / ZP3 (7q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  BAZ1B/ZP3 (7q11)


External links

Nomenclature
HGNC (Hugo)ZP3   13189
Cards
Entrez_Gene (NCBI)ZP3  7784  zona pellucida glycoprotein 3
AliasesOOMD3; ZP3A; ZP3B; ZPC; 
Zp-3
GeneCards (Weizmann)ZP3
Ensembl hg19 (Hinxton)ENSG00000188372 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188372 [Gene_View]  ENSG00000188372 [Sequence]  chr7:76397524-76442071 [Contig_View]  ZP3 [Vega]
ICGC DataPortalENSG00000188372
TCGA cBioPortalZP3
AceView (NCBI)ZP3
Genatlas (Paris)ZP3
WikiGenes7784
SOURCE (Princeton)ZP3
Genetics Home Reference (NIH)ZP3
Genomic and cartography
GoldenPath hg38 (UCSC)ZP3  -     chr7:76397524-76442071 +  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZP3  -     7q11.23   [Description]    (hg19-Feb_2009)
EnsemblZP3 - 7q11.23 [CytoView hg19]  ZP3 - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBIZP3 [Mapview hg19]  ZP3 [Mapview hg38]
OMIM182889   617712   
Gene and transcription
Genbank (Entrez)AK056788 AK292763 BC113949 BI828655 CA421411
RefSeq transcript (Entrez)NM_001110354 NM_007155
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZP3
Cluster EST : UnigeneHs.656137 [ NCBI ]
CGAP (NCI)Hs.656137
Alternative Splicing GalleryENSG00000188372
Gene ExpressionZP3 [ NCBI-GEO ]   ZP3 [ EBI - ARRAY_EXPRESS ]   ZP3 [ SEEK ]   ZP3 [ MEM ]
Gene Expression Viewer (FireBrowse)ZP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7784
GTEX Portal (Tissue expression)ZP3
Human Protein AtlasENSG00000188372-ZP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21754   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21754  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21754
Splice isoforms : SwissVarP21754
PhosPhoSitePlusP21754
Domaine pattern : Prosite (Expaxy)ZP_1 (PS00682)    ZP_2 (PS51034)   
Domains : Interpro (EBI)ZP_dom    ZP_dom_CS   
Domain families : Pfam (Sanger)Zona_pellucida (PF00100)   
Domain families : Pfam (NCBI)pfam00100   
Domain families : Smart (EMBL)ZP (SM00241)  
Conserved Domain (NCBI)ZP3
DMDM Disease mutations7784
Blocks (Seattle)ZP3
SuperfamilyP21754
Human Protein Atlas [tissue]ENSG00000188372-ZP3 [tissue]
Peptide AtlasP21754
HPRD01690
IPIIPI00010350   IPI00218458   IPI00736368   IPI01018785   IPI00924521   IPI00927610   
Protein Interaction databases
DIP (DOE-UCLA)P21754
IntAct (EBI)P21754
FunCoupENSG00000188372
BioGRIDZP3
STRING (EMBL)ZP3
ZODIACZP3
Ontologies - Pathways
QuickGOP21754
Ontology : AmiGOpositive regulation of type IV hypersensitivity  blastocyst formation  humoral immune response mediated by circulating immunoglobulin  positive regulation of leukocyte migration  positive regulation of humoral immune response  extracellular matrix structural constituent  protein binding  extracellular region  extracellular space  intracellular  plasma membrane  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  regulation of signaling receptor activity  positive regulation of phosphatidylinositol biosynthetic process  integral component of membrane  carbohydrate binding  extracellular matrix  extracellular matrix  acrosin binding  acrosin binding  positive regulation of interferon-gamma production  positive regulation of interleukin-4 production  egg coat formation  egg coat formation  positive regulation of T cell proliferation  identical protein binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  phosphatidylinositol-mediated signaling  receptor ligand activity  oocyte development  positive regulation of inflammatory response  collagen-containing extracellular matrix  positive regulation of acrosome reaction  positive regulation of acrosome reaction  negative regulation of binding of sperm to zona pellucida  positive regulation of acrosomal vesicle exocytosis  positive regulation of acrosomal vesicle exocytosis  positive regulation of ovarian follicle development  positive regulation of antral ovarian follicle growth  
Ontology : EGO-EBIpositive regulation of type IV hypersensitivity  blastocyst formation  humoral immune response mediated by circulating immunoglobulin  positive regulation of leukocyte migration  positive regulation of humoral immune response  extracellular matrix structural constituent  protein binding  extracellular region  extracellular space  intracellular  plasma membrane  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  binding of sperm to zona pellucida  regulation of signaling receptor activity  positive regulation of phosphatidylinositol biosynthetic process  integral component of membrane  carbohydrate binding  extracellular matrix  extracellular matrix  acrosin binding  acrosin binding  positive regulation of interferon-gamma production  positive regulation of interleukin-4 production  egg coat formation  egg coat formation  positive regulation of T cell proliferation  identical protein binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  phosphatidylinositol-mediated signaling  receptor ligand activity  oocyte development  positive regulation of inflammatory response  collagen-containing extracellular matrix  positive regulation of acrosome reaction  positive regulation of acrosome reaction  negative regulation of binding of sperm to zona pellucida  positive regulation of acrosomal vesicle exocytosis  positive regulation of acrosomal vesicle exocytosis  positive regulation of ovarian follicle development  positive regulation of antral ovarian follicle growth  
NDEx NetworkZP3
Atlas of Cancer Signalling NetworkZP3
Wikipedia pathwaysZP3
Orthology - Evolution
OrthoDB7784
GeneTree (enSembl)ENSG00000188372
Phylogenetic Trees/Animal Genes : TreeFamZP3
HOVERGENP21754
HOGENOMP21754
Homologs : HomoloGeneZP3
Homology/Alignments : Family Browser (UCSC)ZP3
Gene fusions - Rearrangements
Fusion : QuiverZP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZP3
dbVarZP3
ClinVarZP3
1000_GenomesZP3 
Exome Variant ServerZP3
ExAC (Exome Aggregation Consortium)ENSG00000188372
GNOMAD BrowserENSG00000188372
Varsome BrowserZP3
Genetic variants : HAPMAP7784
Genomic Variants (DGV)ZP3 [DGVbeta]
DECIPHERZP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZP3 
Mutations
ICGC Data PortalZP3 
TCGA Data PortalZP3 
Broad Tumor PortalZP3
OASIS PortalZP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZP3
DgiDB (Drug Gene Interaction Database)ZP3
DoCM (Curated mutations)ZP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZP3 (select a term)
intoGenZP3
Cancer3DZP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182889    617712   
Orphanet
DisGeNETZP3
MedgenZP3
Genetic Testing Registry ZP3
NextProtP21754 [Medical]
TSGene7784
GENETestsZP3
Target ValidationZP3
Huge Navigator ZP3 [HugePedia]
snp3D : Map Gene to Disease7784
BioCentury BCIQZP3
ClinGenZP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7784
Chemical/Pharm GKB GenePA37757
Clinical trialZP3
Miscellaneous
canSAR (ICR)ZP3 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZP3
EVEXZP3
GoPubMedZP3
iHOPZP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:51:52 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.