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ZP4 (zona pellucida glycoprotein 4)

Identity

Alias_symbol (synonym)ZPB
Other aliasZBP
ZP1
Zp-4
HGNC (Hugo) ZP4
LocusID (NCBI) 57829
Atlas_Id 56229
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 238045677 and ends at 238054222 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZP4   15770
Cards
Entrez_Gene (NCBI)ZP4  57829  zona pellucida glycoprotein 4
AliasesZBP; ZP1; ZPB; Zp-4
GeneCards (Weizmann)ZP4
Ensembl hg19 (Hinxton)ENSG00000116996 [Gene_View]  chr1:238045677-238054222 [Contig_View]  ZP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116996 [Gene_View]  chr1:238045677-238054222 [Contig_View]  ZP4 [Vega]
ICGC DataPortalENSG00000116996
TCGA cBioPortalZP4
AceView (NCBI)ZP4
Genatlas (Paris)ZP4
WikiGenes57829
SOURCE (Princeton)ZP4
Genetics Home Reference (NIH)ZP4
Genomic and cartography
GoldenPath hg19 (UCSC)ZP4  -     chr1:238045677-238054222 -  1q43   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZP4  -     1q43   [Description]    (hg38-Dec_2013)
EnsemblZP4 - 1q43 [CytoView hg19]  ZP4 - 1q43 [CytoView hg38]
Mapping of homologs : NCBIZP4 [Mapview hg19]  ZP4 [Mapview hg38]
OMIM613514   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_021186
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZP4
Cluster EST : UnigeneHs.136241 [ NCBI ]
CGAP (NCI)Hs.136241
Alternative Splicing GalleryENSG00000116996
Gene ExpressionZP4 [ NCBI-GEO ]   ZP4 [ EBI - ARRAY_EXPRESS ]   ZP4 [ SEEK ]   ZP4 [ MEM ]
Gene Expression Viewer (FireBrowse)ZP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57829
GTEX Portal (Tissue expression)ZP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12836   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12836  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12836
Splice isoforms : SwissVarQ12836
PhosPhoSitePlusQ12836
Domaine pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)    ZP_1 (PS00682)    ZP_2 (PS51034)   
Domains : Interpro (EBI)P_trefoil_CS    P_trefoil_dom    ZP_dom    ZP_dom_CS   
Domain families : Pfam (Sanger)Trefoil (PF00088)    Zona_pellucida (PF00100)   
Domain families : Pfam (NCBI)pfam00088    pfam00100   
Domain families : Smart (EMBL)PD (SM00018)  ZP (SM00241)  
Conserved Domain (NCBI)ZP4
DMDM Disease mutations57829
Blocks (Seattle)ZP4
SuperfamilyQ12836
Human Protein AtlasENSG00000116996
Peptide AtlasQ12836
HPRD18363
IPIIPI00009612   
Protein Interaction databases
DIP (DOE-UCLA)Q12836
IntAct (EBI)Q12836
FunCoupENSG00000116996
BioGRIDZP4
STRING (EMBL)ZP4
ZODIACZP4
Ontologies - Pathways
QuickGOQ12836
Ontology : AmiGOpositive regulation of humoral immune response  signal transducer activity  extracellular region  proteinaceous extracellular matrix  intracellular  plasma membrane  binding of sperm to zona pellucida  protein kinase A signaling  integral component of membrane  acrosin binding  intracellular signal transduction  positive regulation of T cell proliferation  positive regulation of protein kinase activity  acrosomal vesicle exocytosis  protein kinase C signaling  positive regulation of acrosome reaction  negative regulation of binding of sperm to zona pellucida  
Ontology : EGO-EBIpositive regulation of humoral immune response  signal transducer activity  extracellular region  proteinaceous extracellular matrix  intracellular  plasma membrane  binding of sperm to zona pellucida  protein kinase A signaling  integral component of membrane  acrosin binding  intracellular signal transduction  positive regulation of T cell proliferation  positive regulation of protein kinase activity  acrosomal vesicle exocytosis  protein kinase C signaling  positive regulation of acrosome reaction  negative regulation of binding of sperm to zona pellucida  
NDEx NetworkZP4
Atlas of Cancer Signalling NetworkZP4
Wikipedia pathwaysZP4
Orthology - Evolution
OrthoDB57829
GeneTree (enSembl)ENSG00000116996
Phylogenetic Trees/Animal Genes : TreeFamZP4
HOVERGENQ12836
HOGENOMQ12836
Homologs : HomoloGeneZP4
Homology/Alignments : Family Browser (UCSC)ZP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZP4
dbVarZP4
ClinVarZP4
1000_GenomesZP4 
Exome Variant ServerZP4
ExAC (Exome Aggregation Consortium)ZP4 (select the gene name)
Genetic variants : HAPMAP57829
Genomic Variants (DGV)ZP4 [DGVbeta]
DECIPHER (Syndromes)1:238045677-238054222  ENSG00000116996
CONAN: Copy Number AnalysisZP4 
Mutations
ICGC Data PortalZP4 
TCGA Data PortalZP4 
Broad Tumor PortalZP4
OASIS PortalZP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZP4
DgiDB (Drug Gene Interaction Database)ZP4
DoCM (Curated mutations)ZP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZP4 (select a term)
intoGenZP4
Cancer3DZP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613514   
Orphanet
MedgenZP4
Genetic Testing Registry ZP4
NextProtQ12836 [Medical]
TSGene57829
GENETestsZP4
Huge Navigator ZP4 [HugePedia]
snp3D : Map Gene to Disease57829
BioCentury BCIQZP4
ClinGenZP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57829
Chemical/Pharm GKB GenePA38036
Clinical trialZP4
Miscellaneous
canSAR (ICR)ZP4 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZP4
EVEXZP4
GoPubMedZP4
iHOPZP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:35:18 CET 2017

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