Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2)

Identity

Alias (NCBI)U2AF1-RS2
U2AF1L2
U2AF1RS2
URP
ZC3H22
HGNC (Hugo) ZRSR2
HGNC Alias symbU2AF1-RS2
URP
ZC3H22
HGNC Previous nameU2AF1L2
HGNC Previous nameU2(RNU2) small nuclear RNA auxiliary factor 1-like 2
 U2 small nuclear RNA auxiliary factor 1-like 2
LocusID (NCBI) 8233
Atlas_Id 52759
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 15790451 and ends at 15823259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZRSR2 (Xp22.2) / CNTNAP2 (7q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Classification of myelodysplastic syndromes 2015

External links

Nomenclature
HGNC (Hugo)ZRSR2   23019
LRG (Locus Reference Genomic)LRG_618
Cards
Entrez_Gene (NCBI)ZRSR2    zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
AliasesU2AF1-RS2; U2AF1L2; U2AF1RS2; URP; 
ZC3H22
GeneCards (Weizmann)ZRSR2
Ensembl hg19 (Hinxton)ENSG00000169249 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169249 [Gene_View]  ENSG00000169249 [Sequence]  chrX:15790451-15823259 [Contig_View]  ZRSR2 [Vega]
ICGC DataPortalENSG00000169249
TCGA cBioPortalZRSR2
AceView (NCBI)ZRSR2
Genatlas (Paris)ZRSR2
SOURCE (Princeton)ZRSR2
Genetics Home Reference (NIH)ZRSR2
Genomic and cartography
GoldenPath hg38 (UCSC)ZRSR2  -     chrX:15790451-15823259 +  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZRSR2  -     Xp22.2   [Description]    (hg19-Feb_2009)
GoldenPathZRSR2 - Xp22.2 [CytoView hg19]  ZRSR2 - Xp22.2 [CytoView hg38]
ImmunoBaseENSG00000169249
genome Data Viewer NCBIZRSR2 [Mapview hg19]  
OMIM300028   
Gene and transcription
Genbank (Entrez)AK090845 AK309673 BC050451 BC065719 BC113454
RefSeq transcript (Entrez)NM_005089
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZRSR2
Alternative Splicing GalleryENSG00000169249
Gene ExpressionZRSR2 [ NCBI-GEO ]   ZRSR2 [ EBI - ARRAY_EXPRESS ]   ZRSR2 [ SEEK ]   ZRSR2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZRSR2 [ Firebrowse - Broad ]
GenevisibleExpression of ZRSR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8233
GTEX Portal (Tissue expression)ZRSR2
Human Protein AtlasENSG00000169249-ZRSR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15696   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15696  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15696
Splice isoforms : SwissVarQ15696
PhosPhoSitePlusQ15696
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    RRM_dom_euk    U2AF_small    Znf_CCCH   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00076    pfam00642   
Domain families : Smart (EMBL)RRM_1 (SM00361)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)ZRSR2
Blocks (Seattle)ZRSR2
SuperfamilyQ15696
Human Protein Atlas [tissue]ENSG00000169249-ZRSR2 [tissue]
Peptide AtlasQ15696
HPRD02068
IPIIPI00018954   IPI00639872   
Protein Interaction databases
DIP (DOE-UCLA)Q15696
IntAct (EBI)Q15696
BioGRIDZRSR2
STRING (EMBL)ZRSR2
ZODIACZRSR2
Ontologies - Pathways
QuickGOQ15696
Ontology : AmiGOspliceosomal complex assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein binding  nucleoplasm  spliceosomal complex  U12-type spliceosomal complex  RNA splicing  pre-mRNA 3'-splice site binding  pre-mRNA 3'-splice site binding  metal ion binding  U2AF  
Ontology : EGO-EBIspliceosomal complex assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein binding  nucleoplasm  spliceosomal complex  U12-type spliceosomal complex  RNA splicing  pre-mRNA 3'-splice site binding  pre-mRNA 3'-splice site binding  metal ion binding  U2AF  
NDEx NetworkZRSR2
Atlas of Cancer Signalling NetworkZRSR2
Wikipedia pathwaysZRSR2
Orthology - Evolution
OrthoDB8233
GeneTree (enSembl)ENSG00000169249
Phylogenetic Trees/Animal Genes : TreeFamZRSR2
HOGENOMQ15696
Homologs : HomoloGeneZRSR2
Homology/Alignments : Family Browser (UCSC)ZRSR2
Gene fusions - Rearrangements
Fusion : QuiverZRSR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZRSR2 [hg38]
dbVarZRSR2
ClinVarZRSR2
MonarchZRSR2
1000_GenomesZRSR2 
Exome Variant ServerZRSR2
GNOMAD BrowserENSG00000169249
Varsome BrowserZRSR2
Genomic Variants (DGV)ZRSR2 [DGVbeta]
DECIPHERZRSR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZRSR2 
Mutations
ICGC Data PortalZRSR2 
TCGA Data PortalZRSR2 
Broad Tumor PortalZRSR2
OASIS PortalZRSR2 [ Somatic mutations - Copy number]
Cancer Gene: CensusZRSR2 
Somatic Mutations in Cancer : COSMICZRSR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZRSR2
Mutations and Diseases : HGMDZRSR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ZRSR2
DgiDB (Drug Gene Interaction Database)ZRSR2
DoCM (Curated mutations)ZRSR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZRSR2 (select a term)
intoGenZRSR2
Cancer3DZRSR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300028   
Orphanet
DisGeNETZRSR2
MedgenZRSR2
Genetic Testing Registry ZRSR2
NextProtQ15696 [Medical]
GENETestsZRSR2
Target ValidationZRSR2
Huge Navigator ZRSR2 [HugePedia]
ClinGenZRSR2
Clinical trials, drugs, therapy
MyCancerGenomeZRSR2
Protein Interactions : CTD
Pharm GKB GenePA162410930
PharosQ15696
Clinical trialZRSR2
Miscellaneous
canSAR (ICR)ZRSR2 (select the gene name)
HarmonizomeZRSR2
DataMed IndexZRSR2
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZRSR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:45:35 CET 2021
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