ZYX (zyxin)

2003-11-01  

Identity

HGNC
LOCATION
7q34
LOCUSID
ALIAS
ESP-2,HED-2
FUSION GENES

Other Information

Locus ID:

NCBI: 7791
MIM: 602002
HGNC: 13200
Ensembl: ENSG00000159840

Variants:

dbSNP: 7791
ClinVar: 7791
TCGA: ENSG00000159840
COSMIC: ZYX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159840ENST00000322764Q15942
ENSG00000159840ENST00000354434H0Y2Y8
ENSG00000159840ENST00000392910Q15942
ENSG00000159840ENST00000436448H7C3D3
ENSG00000159840ENST00000446634C9JJK5
ENSG00000159840ENST00000449630H7C3R3
ENSG00000159840ENST00000457235C9IZ41

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
214869522011Actomyosin-generated tension controls the molecular kinetics of focal adhesions.76
186824962008Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.73
223956102012Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.45
150040282004Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1.38
150846012004Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain.37
218894432011The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration.24
227782672012Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.24
157488902005The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells.19
266111252015VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.19

Citation

Dessen P

ZYX (zyxin)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/45507/zyx