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ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1)

Identity

Alias_nameszinc finger, ZZ-type with EF hand domain 1
Alias_symbol (synonym)KIAA0399
ZZZ4
FLJ10821
Other alias
HGNC (Hugo) ZZEF1
LocusID (NCBI) 23140
Atlas_Id 76519
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 4004445 and ends at 4142959 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERGIC1 (5q35.1) / ZZEF1 (17p13.2)HACL1 (3p25.1) / ZZEF1 (17p13.2)PGS1 (17q25.3) / ZZEF1 (17p13.2)
UBE2G1 (17p13.2) / ZZEF1 (17p13.2)UTS2 (1p36.23) / ZZEF1 (17p13.2)VPS53 (17p13.3) / ZZEF1 (17p13.2)
ZZEF1 (17p13.2) / ANKFY1 (17p13.2)ZZEF1 (17p13.2) / CCDC144A (17p11.2)ZZEF1 (17p13.2) / ZZEF1 (17p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(17;17)(p11;p13) ZZEF1/CCDC144A
t(17;17)(p13;p13) ZZEF1/ANKFY1
t(17;17)(p13;p13) VPS53/ZZEF1

External links

Nomenclature
HGNC (Hugo)ZZEF1   29027
Cards
Entrez_Gene (NCBI)ZZEF1  23140  zinc finger ZZ-type and EF-hand domain containing 1
AliasesZZZ4
GeneCards (Weizmann)ZZEF1
Ensembl hg19 (Hinxton)ENSG00000074755 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074755 [Gene_View]  ENSG00000074755 [Sequence]  chr17:4004445-4142959 [Contig_View]  ZZEF1 [Vega]
ICGC DataPortalENSG00000074755
TCGA cBioPortalZZEF1
AceView (NCBI)ZZEF1
Genatlas (Paris)ZZEF1
WikiGenes23140
SOURCE (Princeton)ZZEF1
Genetics Home Reference (NIH)ZZEF1
Genomic and cartography
GoldenPath hg38 (UCSC)ZZEF1  -     chr17:4004445-4142959 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZZEF1  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblZZEF1 - 17p13.2 [CytoView hg19]  ZZEF1 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIZZEF1 [Mapview hg19]  ZZEF1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB007859 AI205543 AK001683 AK122719 AK124719
RefSeq transcript (Entrez)NM_015113
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZZEF1
Cluster EST : UnigeneHs.277624 [ NCBI ]
CGAP (NCI)Hs.277624
Alternative Splicing GalleryENSG00000074755
Gene ExpressionZZEF1 [ NCBI-GEO ]   ZZEF1 [ EBI - ARRAY_EXPRESS ]   ZZEF1 [ SEEK ]   ZZEF1 [ MEM ]
Gene Expression Viewer (FireBrowse)ZZEF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23140
GTEX Portal (Tissue expression)ZZEF1
Human Protein AtlasENSG00000074755-ZZEF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43149   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43149  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43149
Splice isoforms : SwissVarO43149
PhosPhoSitePlusO43149
Domaine pattern : Prosite (Expaxy)DOC (PS51284)    EF_HAND_2 (PS50222)    ZF_ZZ_1 (PS01357)    ZF_ZZ_2 (PS50135)   
Domains : Interpro (EBI)APC_su10/DOC_dom    CUB_dom    EF-hand-dom_pair    EF_hand_dom    Galactose-bd-like    Znf_ZZ   
Domain families : Pfam (Sanger)ANAPC10 (PF03256)    ZZ (PF00569)   
Domain families : Pfam (NCBI)pfam03256    pfam00569   
Domain families : Smart (EMBL)APC10 (SM01337)  EFh (SM00054)  ZnF_ZZ (SM00291)  
Conserved Domain (NCBI)ZZEF1
DMDM Disease mutations23140
Blocks (Seattle)ZZEF1
SuperfamilyO43149
Human Protein Atlas [tissue]ENSG00000074755-ZZEF1 [tissue]
Peptide AtlasO43149
HPRD15906
IPIIPI00385631   IPI00790964   IPI00847913   IPI00166589   IPI00152672   
Protein Interaction databases
DIP (DOE-UCLA)O43149
IntAct (EBI)O43149
FunCoupENSG00000074755
BioGRIDZZEF1
STRING (EMBL)ZZEF1
ZODIACZZEF1
Ontologies - Pathways
QuickGOO43149
Ontology : AmiGOcalcium ion binding  zinc ion binding  
Ontology : EGO-EBIcalcium ion binding  zinc ion binding  
NDEx NetworkZZEF1
Atlas of Cancer Signalling NetworkZZEF1
Wikipedia pathwaysZZEF1
Orthology - Evolution
OrthoDB23140
GeneTree (enSembl)ENSG00000074755
Phylogenetic Trees/Animal Genes : TreeFamZZEF1
HOVERGENO43149
HOGENOMO43149
Homologs : HomoloGeneZZEF1
Homology/Alignments : Family Browser (UCSC)ZZEF1
Gene fusions - Rearrangements
Fusion : QuiverZZEF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZZEF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZZEF1
dbVarZZEF1
ClinVarZZEF1
1000_GenomesZZEF1 
Exome Variant ServerZZEF1
ExAC (Exome Aggregation Consortium)ENSG00000074755
GNOMAD BrowserENSG00000074755
Varsome BrowserZZEF1
Genetic variants : HAPMAP23140
Genomic Variants (DGV)ZZEF1 [DGVbeta]
DECIPHERZZEF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZZEF1 
Mutations
ICGC Data PortalZZEF1 
TCGA Data PortalZZEF1 
Broad Tumor PortalZZEF1
OASIS PortalZZEF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZZEF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZZEF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZZEF1
DgiDB (Drug Gene Interaction Database)ZZEF1
DoCM (Curated mutations)ZZEF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZZEF1 (select a term)
intoGenZZEF1
Cancer3DZZEF1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETZZEF1
MedgenZZEF1
Genetic Testing Registry ZZEF1
NextProtO43149 [Medical]
TSGene23140
GENETestsZZEF1
Target ValidationZZEF1
Huge Navigator ZZEF1 [HugePedia]
snp3D : Map Gene to Disease23140
BioCentury BCIQZZEF1
ClinGenZZEF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23140
Chemical/Pharm GKB GenePA134938508
Clinical trialZZEF1
Miscellaneous
canSAR (ICR)ZZEF1 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZZEF1
EVEXZZEF1
GoPubMedZZEF1
iHOPZZEF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:41:05 CEST 2018
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