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GPX1 (Glutathione Peroxidase 1)

Written2013-11Mikhail V Kulak, Ronald J Weigel
Department of Surgery, University of Iowa, 200 Hawkins Drive, 1509 JCP, Iowa City, IA, 52242, United States

(Note : for Links provided by Atlas : click)

Identity

Other aliasGPXD
GSHPX1
HGNC (Hugo) GPX1
LocusID (NCBI) 2876
Atlas_Id 40747
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49357171 and ends at 49358600 bp from pter ( according to hg19-Feb_2009)  [Mapping GPX1.png]
Local_order - C3orf62, chr3:49306030-49314508, chromosome 3 open reading frame 62
- USP4, 3p21.31, chr3:49314577-49377536, ubiquitin specific peptidase 4 (proto-oncogene), transcript variant 2
- USP4, 3p21.31, chr3:49314577-49377536, ubiquitin specific peptidase 4 (proto-oncogene), transcript variant 1
- USP4, 3p21.31, chr3:49349218-49377536, ubiquitin specific peptidase 4 (proto-oncogene), transcript variant 3
- GPX1, 3p21.31, chr3:49394609-49395791, glutathione peroxidase 1, transcript variant 1
- GPX1, 3p21.31, chr3:49394609-49395791, glutathione peroxidase 1, transcript variant 2
- RHOA, 3p21.31, chr3:49396579-49449526, ras homolog family member A
- TCTA, 3p21.31, chr3:49449639-49453909, T-cell leukemia translocation altered
- AMT, 3p21.31, chr3:49454211-49460111, aminomethyltransferase
The colocalization of genes is presented on figure 1.
 
Fusion genes
(updated 2016)
GPX1 (3p21.31) / RPL3 (22q13.1)GPX1 (3p21.31) / SLC35B3 (6p24.3)
Note According to hg19/GRCh37-Feb_2009:
- GPX1 at chr3:49394609-49395791 - (NM_000581) glutathione peroxidase 1 isoform 1
- GPX1 at chr3:49394609-49395791 - (NM_201397) glutathione peroxidase 1 isoform 2
GPX1 is an enzyme that reduces hydrogen and lipid peroxides to water or alcohols by reducing glutathione. Systematic name: glutathione: hydrogen-peroxide oxidoreductase.
Reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O [RN:R00274].

DNA/RNA

 
Description According to hg19/GRCh37-Feb_2009:
- Start: chr3:49394609 bp from pter
- End: chr3:49395791 bp from pter
- Size: 1183 bases
- Orientation: minus strand
Transcription Two alternatively spliced transcript variants encoding distinct isoforms have been shown for this gene Nucleotide.
Isoform 1 represents the shorter transcript (921 bases), RefSeq: NM_000581.2, which is comprised of 2 exons and coding the longer isoform (Figure 2A).
Isoform 2 is 1200 bases, RefSeq: NM_201397.1, also this variant is intronless. Due to the fact that this variant is not spliced the open reading frame is shifted and the protein is shorter from C-terminus compared to isoform 1 (Figure 2B).
Pseudogene Two pseudogenes have been found so far. GPX1P1 glutathione peroxidase pseudogene 1 (other names: GPXL2, GPXP1) is located at the locus Xp22.2 (HGNC:4560). GPX1P2 glutathione peroxidase pseudogene 2 (other names: GPXP2, GPXP2P) is located at the locus 21q21.3 (HGNC:4561).

Protein

Description 203 aa (Accession: NM_000581.2) isoform 1; 98 aa (Accession: NM_201397.1) isoform 2.
GPX1 belongs to the family of glutathione peroxidases (Kryukov et al., 2003). GPX1, GPX2, GPX3, GPX4 and GPX6 utilize a UGA codon that specifies insertion of a selenocysteine residue which is critical to protein function (Arthur, 2000). Both isoforms contain selenocysteine at the position 49 (Mullenbach et al., 1988).
Expression GPX1 is found at high levels in tissues exposed to high oxygen tensions such as in the lungs, at the cellular elements of blood, liver, kidney and pancreas, and also at moderate levels in heart, muscle and brain (Esposito et al., 2000; Moscow et al., 1992).
Regulation: Aberrant promotor methylation and consequence silencing has been shown for GPX1 expression during several pathological conditions in breast (Kulak et al., 2012) and gastric cancer (Min et al., 2012); whereas, induction of GPX1 gene expression was associated with transcription factors such TFAP2C in breast cancer (Kulak et al., 2012) and ZNF143 transcription factor under the mitochondrial respiratory dysfunction (Lu et al., 2012).
Localisation The protein is detected in cytoplasm and mitochondria but the ratio may vary and be dependent on cellular function (Chiu et al., 1976; Timcenko-Youssef et al., 1985; Reeves et al., 2009).
Function GPX1 is an enzyme of mammals and birds which protects against the damaging effects of various endogenously formed hydroperoxides and hydrogen peroxide as follows: H2O2+ 2 GSH - 2 H2O + GSS and RGOH + 2 GSH - GSSG + ROH + H2O where ROOH represents lipid hydroperoxides, membrane associated phospholipid hydroperoxides (Ursini et al., 1985; Reeves et al., 2009).
Homology The GPX1 gene is present in vertebrates and across all mammals demonstrates homology of about 70% at the nucleotide level (Mariotti et al., 2012).

Mutations

Note Single nucleotide and ALA polymorphism have been shown for GPX1.
The 5'-UTR of GPX1 was found to contain a single nucleotide C/T polymorphism rs 1800668 located at the position ch3:49395757. The CC genotype demonstrates relatively high activity of GPX1 compared to CT or TT variant of alleles; however, the polymorphism does not alter the protein structure so differences in activity might be associated with transcriptional regulation since rs 1080668 site is located within promoter of GPX1 (Najafi et al., 2012).
A single nucleotide polymorphism rs 1050450 at the position ch3:49394834 leads to Pro198->Leu (C->T) substitution in GPX1. Many publications suggested an associated increased risk of cancer with the TT (Leu) genotype. However, extended meta-analysis failed to find a significant correlation of the polymorphism (rs 1050450) with cancer risk, although the TT GPX1 genotype examined in erythrocytes demonstrated significantly lower functional activity (Hong et al., 2012).
ALA N-terminal polymorphism has been shown for the GPX1 gene. In this variant, the number of GCG repeats is altered resulting in a protein with a variable number of alanines 5, 6, or 7 (Shen et al., 1994). Some association between 5-ALA genotype and high risk of breast cancer have been shown (Knight et al., 2004). However, associations between specific genotypes and the risk of prostate cancer have not been found (Kote-Jarai et al., 2002).

Implicated in

Note
  
Entity Various cancers
Oncogenesis GPX1 involvment in certain cancers has been shown by several line of evidence.
  
  
Entity Lung cancer
Note The expression of GPX1 may be altered through LOH (loss of heterozygosity) of GPX1 which leads to decrease gene activity and increased risk of lung cancer (Hardie et al., 2000). Up-regulation of GPX1 in erythrocytes may be seen under several conditions such as hypoxia or with treatment with chemicals such as alcohol (Raaschou-Nielsen et al., 2006) but GPX1 activity tended to be significantly lower in smokers compared to non-smokers (Ravn-Haren et al., 2006) and these differences have been hypothesized to account for increased risk of lung cancer in smokers (Ratnasinghe et al., 2000). However high level of GPX1 was shown in lung cancer compared to non-malignant tissue (Blomquist et al., 2009).
  
  
Entity Breast cancer
Note Decrease GPX1 activity due to LOH (Hu et al., 2003; Hu et al., 2005) or aberrant hypermethylation of the GPX1 gene promotor (Kulak et al., 2012) leads to high risk of breast cancer.
  
  
Entity Renal cancer
Note Selenium consumption plays a dramatic role on GPX1 activity. Selenium in the diet altered both the mRNA and protein levels of GPX1 in mice (Sunde et al., 2009) whereas in pigs selenoprotein gene expression and/or protein production is not dependent on prolonged dietary selenium deficiency or excess (Liu et al., 2012). In humans no association was found between the Se status and breast or colorectal cancer risk (Dennert et al., 2011), but poor Se status was indicative of high mortality rate in renal cancer patients (Jean-Claude et al., 2012; Meyer et al., 2012).
  
  
Entity Gastric cancer
Note Aberrant hypermethylation of the GPX1 gene promotor may decrease GPX1 expression and has been described as a mechanism of GPX1 silencing in gastric cancer (Jee et al., 2009).
  
  
Entity Bladder cancer
Note Relatively high level of GPX1 was observed in bladder cancer (Reszka, 2012).
  
  
Entity Anticancer drug resistance
Note One hypothesis proposes that when damaged cells have progressed to a precancerous status, increased GPX1 activity may become procarcinogenic, presumably due to inhibition of hydroperoxide-mediated apoptosis (Chu et al., 2004) and may be responsible for antitumor drug resistance such as doxorubicin (Gouazé et al., 2001) which acts through increasing ROS products in cells (Wang et al., 2004).
  
  
Entity Genetic polymorphisms and cancer
Note As mentioned above, genetic polymorphisms have been reported for GPX1. Investigations have attempted to demonstrate an association with cancer incidence, however, no consistent association has been found to date (Lei et al., 2007; Arsova-Sarafinovska et al., 2009; Erdem er al., 2012; Hong et al., 2012).
  

Bibliography

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Association of GPX1 polymorphism, GPX activity and prostate cancer risk.
Erdem O, Eken A, Akay C, Arsova-Sarafinovska Z, Matevska N, Suturkova L, Erten K, Ozgok Y, Dimovski A, Sayal A, Aydin A.
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Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene.
Esposito LA, Kokoszka JE, Waymire KG, Cottrell B, MacGregor GR, Wallace DC.
Free Radic Biol Med. 2000 Mar 1;28(5):754-66.
PMID 10754271
 
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.
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Mol Pharmacol. 2001 Sep;60(3):488-96.
PMID 11502879
 
The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer.
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GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk.
Hong Z, Tian C, Zhang X.
Mol Biol Rep. 2013 Feb;40(2):1801-12. doi: 10.1007/s11033-012-2234-3. Epub 2012 Oct 17.
PMID 23073788
 
Allelic loss of the gene for the GPX1 selenium-containing protein is a common event in cancer.
Hu Y, Benya RV, Carroll RE, Diamond AM.
J Nutr. 2005 Dec;135(12 Suppl):3021S-3024S. (REVIEW)
PMID 16317164
 
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Hu YJ, Diamond AM.
Cancer Res. 2003 Jun 15;63(12):3347-51.
PMID 12810669
 
Clinical and economic impact of malnutrition per se on the postoperative course of colorectal cancer patients.
Jean-Claude M, Emmanuelle P, Juliette H, Michele B, Gerard D, Eric F, Xavier H, Bertrand L, Jean-Fabien Z, Yves P, Gerard N.
Clin Nutr. 2012 Dec;31(6):896-902. doi: 10.1016/j.clnu.2012.03.011. Epub 2012 May 19.
PMID 22608918
 
Identification of genes epigenetically silenced by CpG methylation in human gastric carcinoma.
Jee CD, Kim MA, Jung EJ, Kim J, Kim WH.
Eur J Cancer. 2009 May;45(7):1282-93. doi: 10.1016/j.ejca.2008.12.027. Epub 2009 Feb 3.
PMID 19195878
 
Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry.
Knight JA, Onay UV, Wells S, Li H, Shi EJ, Andrulis IL, Ozcelik H.
Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):146-9.
PMID 14744747
 
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.
Kote-Jarai Z, Durocher F, Edwards SM, Hamoudi R, Jackson RA, Ardern-Jones A, Murkin A, Dearnaley DP, Kirby R, Houlston R, Easton DF, Eeles R; CRC/BPG UK Familial Prostrate Cancer Collaborators.
Prostate Cancer Prostatic Dis. 2002;5(3):189-92.
PMID 12496980
 
Characterization of mammalian selenoproteomes.
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PMID 12775843
 
Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer.
Kulak MV, Cyr AR, Woodfield GW, Bogachek M, Spanheimer PM, Li T, Price DH, Domann FE, Weigel RJ.
Oncogene. 2013 Aug 22;32(34):4043-51. doi: 10.1038/onc.2012.400. Epub 2012 Sep 10.
PMID 22964634
 
Metabolic regulation and function of glutathione peroxidase-1.
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Annu Rev Nutr. 2007;27:41-61. (REVIEW)
PMID 17465855
 
Prolonged dietary selenium deficiency or excess does not globally affect selenoprotein gene expression and/or protein production in various tissues of pigs.
Liu Y, Zhao H, Zhang Q, Tang J, Li K, Xia XJ, Wang KN, Li K, Lei XG.
J Nutr. 2012 Aug;142(8):1410-6. doi: 10.3945/jn.112.159020. Epub 2012 Jun 27.
PMID 22739382
 
ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction.
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PMID 23152058
 
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Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
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Citation

This paper should be referenced as such :
Kulak, MV ; Weigel, RJ
GPX1 (Glutathione Peroxidase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(7):465-469.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/GPX1ID40747ch3p21.html


External links

Nomenclature
HGNC (Hugo)GPX1   4553
Cards
AtlasGPX1ID40747ch3p21
Entrez_Gene (NCBI)GPX1  2876  glutathione peroxidase 1
AliasesGPXD; GSHPX1
GeneCards (Weizmann)GPX1
Ensembl hg19 (Hinxton)ENSG00000233276 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000233276 [Gene_View]  chr3:49357171-49358600 [Contig_View]  GPX1 [Vega]
ICGC DataPortalENSG00000233276
TCGA cBioPortalGPX1
AceView (NCBI)GPX1
Genatlas (Paris)GPX1
WikiGenes2876
SOURCE (Princeton)GPX1
Genetics Home Reference (NIH)GPX1
Genomic and cartography
GoldenPath hg38 (UCSC)GPX1  -     chr3:49357171-49358600 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPX1  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblGPX1 - 3p21.31 [CytoView hg19]  GPX1 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIGPX1 [Mapview hg19]  GPX1 [Mapview hg38]
OMIM138320   614164   
Gene and transcription
Genbank (Entrez)AK130160 AK225835 AW079514 BC000742 BC007865
RefSeq transcript (Entrez)NM_000581 NM_001329455 NM_001329502 NM_001329503 NM_201397
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPX1
Cluster EST : UnigeneHs.76686 [ NCBI ]
CGAP (NCI)Hs.76686
Alternative Splicing GalleryENSG00000233276
Gene ExpressionGPX1 [ NCBI-GEO ]   GPX1 [ EBI - ARRAY_EXPRESS ]   GPX1 [ SEEK ]   GPX1 [ MEM ]
Gene Expression Viewer (FireBrowse)GPX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2876
GTEX Portal (Tissue expression)GPX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07203   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07203  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07203
Splice isoforms : SwissVarP07203
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
PhosPhoSitePlusP07203
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
Conserved Domain (NCBI)GPX1
DMDM Disease mutations2876
Blocks (Seattle)GPX1
PDB (SRS)2F8A   
PDB (PDBSum)2F8A   
PDB (IMB)2F8A   
PDB (RSDB)2F8A   
Structural Biology KnowledgeBase2F8A   
SCOP (Structural Classification of Proteins)2F8A   
CATH (Classification of proteins structures)2F8A   
SuperfamilyP07203
Human Protein AtlasENSG00000233276
Peptide AtlasP07203
HPRD11749
IPIIPI00927606   IPI00929743   IPI00398780   
Protein Interaction databases
DIP (DOE-UCLA)P07203
IntAct (EBI)P07203
FunCoupENSG00000233276
BioGRIDGPX1
STRING (EMBL)GPX1
ZODIACGPX1
Ontologies - Pathways
QuickGOP07203
Ontology : AmiGOresponse to reactive oxygen species  temperature homeostasis  endothelial cell development  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  glutathione peroxidase activity  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  cytosol  purine nucleotide catabolic process  triglyceride metabolic process  glutathione metabolic process  sensory perception of sound  intrinsic apoptotic signaling pathway in response to oxidative stress  response to xenobiotic stimulus  response to symbiotic bacterium  UV protection  response to selenium ion  response to gamma radiation  SH3 domain binding  protein oxidation  lipoxygenase pathway  response to hydroperoxide  regulation of mammary gland epithelial cell proliferation  cellular response to oxidative stress  regulation of gene expression, epigenetic  vasodilation  response to hydrogen peroxide  hydrogen peroxide catabolic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  skeletal muscle tissue regeneration  regulation of neuron apoptotic process  blood vessel endothelial cell migration  fat cell differentiation  cell redox homeostasis  skeletal muscle fiber development  myoblast proliferation  interaction with symbiont  positive regulation of protein kinase B signaling  heart contraction  angiogenesis involved in wound healing  regulation of proteasomal protein catabolic process  extracellular exosome  negative regulation of release of cytochrome c from mitochondria  Lewy body  cellular oxidant detoxification  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  positive regulation of supramolecular fiber organization  
Ontology : EGO-EBIresponse to reactive oxygen species  temperature homeostasis  endothelial cell development  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  glutathione peroxidase activity  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  cytosol  purine nucleotide catabolic process  triglyceride metabolic process  glutathione metabolic process  sensory perception of sound  intrinsic apoptotic signaling pathway in response to oxidative stress  response to xenobiotic stimulus  response to symbiotic bacterium  UV protection  response to selenium ion  response to gamma radiation  SH3 domain binding  protein oxidation  lipoxygenase pathway  response to hydroperoxide  regulation of mammary gland epithelial cell proliferation  cellular response to oxidative stress  regulation of gene expression, epigenetic  vasodilation  response to hydrogen peroxide  hydrogen peroxide catabolic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  skeletal muscle tissue regeneration  regulation of neuron apoptotic process  blood vessel endothelial cell migration  fat cell differentiation  cell redox homeostasis  skeletal muscle fiber development  myoblast proliferation  interaction with symbiont  positive regulation of protein kinase B signaling  heart contraction  angiogenesis involved in wound healing  regulation of proteasomal protein catabolic process  extracellular exosome  negative regulation of release of cytochrome c from mitochondria  Lewy body  cellular oxidant detoxification  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  positive regulation of supramolecular fiber organization  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]    Cardiac Protection Against ROS [Genes]   
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis    Amyotrophic lateral sclerosis (ALS)    Huntington's disease   
REACTOMEP07203 [protein]
REACTOME PathwaysR-HSA-74259 [pathway]   
NDEx NetworkGPX1
Atlas of Cancer Signalling NetworkGPX1
Wikipedia pathwaysGPX1
Orthology - Evolution
OrthoDB2876
GeneTree (enSembl)ENSG00000233276
Phylogenetic Trees/Animal Genes : TreeFamGPX1
HOVERGENP07203
HOGENOMP07203
Homologs : HomoloGeneGPX1
Homology/Alignments : Family Browser (UCSC)GPX1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX1
dbVarGPX1
ClinVarGPX1
1000_GenomesGPX1 
Exome Variant ServerGPX1
ExAC (Exome Aggregation Consortium)GPX1 (select the gene name)
Genetic variants : HAPMAP2876
Genomic Variants (DGV)GPX1 [DGVbeta]
DECIPHERGPX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPX1 
Mutations
ICGC Data PortalGPX1 
TCGA Data PortalGPX1 
Broad Tumor PortalGPX1
OASIS PortalGPX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GPX1
DgiDB (Drug Gene Interaction Database)GPX1
DoCM (Curated mutations)GPX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPX1 (select a term)
intoGenGPX1
NCG5 (London)GPX1
Cancer3DGPX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138320    614164   
Orphanet
MedgenGPX1
Genetic Testing Registry GPX1
NextProtP07203 [Medical]
TSGene2876
GENETestsGPX1
Target ValidationGPX1
Huge Navigator GPX1 [HugePedia]
snp3D : Map Gene to Disease2876
BioCentury BCIQGPX1
ClinGenGPX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2876
Chemical/Pharm GKB GenePA28949
Clinical trialGPX1
Miscellaneous
canSAR (ICR)GPX1 (select the gene name)
Probes
Litterature
PubMed305 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPX1
EVEXGPX1
GoPubMedGPX1
iHOPGPX1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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