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| | GSDMA is involved in TGF-beta signaling which regulates apoptosis induction in pit cells of the gastric epithelium. Signaling from TGF-beta receptor up-regulates LMO1, a transcription factor. LMO1 binds to the promoter of GSDMA gene and enhances its expression, that results in the apoptosis induction in the pit cells. |
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| Description | The GSDMA gene encodes a 445 amino acid protein with estimated molecular weight of 49377.95 Da. The Gasdermin family proteins have 9 conserved motifs but no known functional motif. |
| Expression | GSDMA protein is expressed in pit cells of the gastric epithelium, where it is involved in maintenance of homeostasis by its apoptosis induction ability under TGF-beta signaling. Its expression was also observed in epithelial cells of the esophagus, skin and mammary gland. |
| Localisation | Cytoplasm. |
| Function | Apoptosis induction, but detail is unknown. |
| Homology | Human genome possesses its three paralogues, GSDMB, GSDMC and GSDMD. Both N- and C-terminal amino acids are conserved among them. |
| Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. |
| Lunny DP, Weed E, Nolan PM, Marquardt A, Augustin M, Porter RM. |
| J Invest Dermatol. 2005 Mar;124(3):615-21. |
| PMID 15737203 |
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| GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. |
| Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. |
| Oncogene. 2007 Oct 4;26(45):6488-98. Epub 2007 Apr 30. |
| PMID 17471240 |
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| Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. |
| Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. |
| Mamm Genome. 2000 Sep;11(9):718-24. |
| PMID 10967128 |
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| Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. |
| Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H. |
| Genes Chromosomes Cancer. 2009 Mar;48(3):261-71. |
| PMID 19051310 |
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| Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. |
| Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, Sumiyama K, Sagai T, Shiroishi T. |
| Genomics. 2007 May;89(5):618-29. Epub 2007 Mar 12. |
| PMID 17350798 |
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