Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SPECC1 (sperm antigen HCMOGT-1)

Written2004-09Claudio Panarello
Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini 5, 16147 Genova, Italy

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)CYTSB
HCMOGT-1 (sperm antigen HCMOGT-1)
HCMOGT-1
HGNC (Hugo) SPECC1
HGNC Alias symbHCMOGT-1
FLJ36955
NSP
HGNC Alias namesperm antigen HCMOGT 1
 cytokinesis and spindle organization B
HGNC Previous nameCYTSB
HGNC Previous namecytospin B
LocusID (NCBI) 92521
Atlas_Id 174
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 20087022 and ends at 20239430 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping SPECC1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PDGFRB (5q32)::SPECC1 (17p11.2)SPECC1 (17p11.2)::CDC27 (17q21.32)SPECC1 (17p11.2)::PDGFRB (5q32)
SPECC1 (17p11.2)::SPECC1 (17p11.2)SPECC1 (17p11.2)::TMEM11 (17p11.2)SPECC1 (17p11.2)::VPS54 (2p14)

DNA/RNA

Description 2,7 Kb; coding sequence: 2,2Kb

Protein

Description 759 ammino acids; 84, 92 KDa; contains coiled-coil domains.
Expression Widely expressed.

Implicated in

Note
  
Entity ---> PDGFRB/SPECC1
Disease Juvenile myelomonocytic leukemia.
Hybrid/Mutated Gene 5' HCMOGT-1/3' PDGFRB
  

Bibliography

Nitrosative stress in rotated three-dimensional colorectal carcinoma cell cultures induces microtubule depolymerization and apoptosis.
Laguinge LM, Lin S, Samara RN, Salesiotis AN, Jessup JM
Cancer research. 2004 ; 64 (8) : 2643-2648.
PMID 15087371
 

Citation

This paper should be referenced as such :
Panarello, C
HCMOGT-1 (sperm antigen HCMOGT-1)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):299-299.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;17)(q33;p11.2) SPECC1::PDGFRB


External links

Nomenclature
HGNC (Hugo)SPECC1   30615
Cards
AtlasHCMOGT1ID174
Entrez_Gene (NCBI)SPECC1    sperm antigen with calponin homology and coiled-coil domains 1
AliasesCYTSB; HCMOGT-1; HCMOGT1; NSP; 
NSP5
GeneCards (Weizmann)SPECC1
Ensembl hg19 (Hinxton)ENSG00000128487 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128487 [Gene_View]  ENSG00000128487 [Sequence]  chr17:20087022-20239430 [Contig_View]  SPECC1 [Vega]
ICGC DataPortalENSG00000128487
TCGA cBioPortalSPECC1
AceView (NCBI)SPECC1
Genatlas (Paris)SPECC1
SOURCE (Princeton)SPECC1
Genetics Home Reference (NIH)SPECC1
Genomic and cartography
GoldenPath hg38 (UCSC)SPECC1  -     chr17:20087022-20239430 +  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SPECC1  -     17p11.2   [Description]    (hg19-Feb_2009)
GoldenPathSPECC1 - 17p11.2 [CytoView hg19]  SPECC1 - 17p11.2 [CytoView hg38]
ImmunoBaseENSG00000128487
Genome Data Viewer NCBISPECC1 [Mapview hg19]  
OMIM608793   
Gene and transcription
Genbank (Entrez)AB041533 AI950511 AK295093 AK295811 AK298601
RefSeq transcript (Entrez)NM_001033553 NM_001033554 NM_001033555 NM_001243438 NM_001243439 NM_001386077 NM_001386078 NM_001386079 NM_001386080 NM_001386081 NM_001386082 NM_001386083 NM_001386084 NM_001386085 NM_152904
Consensus coding sequences : CCDS (NCBI)SPECC1
Gene ExpressionSPECC1 [ NCBI-GEO ]   SPECC1 [ EBI - ARRAY_EXPRESS ]   SPECC1 [ SEEK ]   SPECC1 [ MEM ]
Gene Expression Viewer (FireBrowse)SPECC1 [ Firebrowse - Broad ]
GenevisibleExpression of SPECC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92521
GTEX Portal (Tissue expression)SPECC1
Human Protein AtlasENSG00000128487-SPECC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SPECC1
Human Protein Atlas [tissue]ENSG00000128487-SPECC1 [tissue]
HPRD12301
Protein Interaction databases
BioGRIDSPECC1
STRING (EMBL)SPECC1
ZODIACSPECC1
Ontologies - Pathways
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSPECC1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 21:19:24 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.