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HOXA9 (homeobox A9)

Written1998-01Jean-loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasHOX1G (homeobox-1G);
LocusID (NCBI) 3205
Atlas_Id 61
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD5 (12p12.1) / HOXA9 (7p15.2)GATA2 (3q21.3) / HOXA9 (7p15.2)HOXA9 (7p15.2) / MSI2 (17q22)
HOXA9 (7p15.2) / NUP98 (11p15.4)MED12 (Xq13.1) / HOXA9 (7p15.2)MSI2 (17q22) / HOXA9 (7p15.2)
NUP98 (11p15.4) / HOXA9 (7p15.2)

Protein

Description 129 amino acids; DNA binding domain (homeobox) in C-term
Localisation nuclear
Function sequence specific transcription factor; role during embryonic development (patterning); HOX genes are also expressed in adult tissues, including blood cells; probable role in blood cell differenciation
Homology with class 1 homeodomain proteins

Implicated in

Note
  
Entity t(7;11)(p15;p15)/AML --> NUP98- HOXA9
Disease M2-M4 AML mostly; occasionally: CML-like cases
Prognosis mean survival: 15 mths
Cytogenetics sole anomaly most often
Hybrid/Mutated Gene 5' NUP98 - 3' HOXA9
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the HOXA9 homeobox
  

Breakpoints

 

Bibliography

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.
Borrow J, Shearman AM, Stanton VP Jr, Becher R, Collins T, Williams AJ, Dubé I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE
Nature genetics. 1996 ; 12 (2) : 159-167.
PMID 8563754
 
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.
Lawrence HJ, Helgason CD, Sauvageau G, Fong S, Izon DJ, Humphries RK, Largman C
Blood. 1997 ; 89 (6) : 1922-1930.
PMID 9058712
 
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.
Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD Jr
Nature genetics. 1996 ; 12 (2) : 154-158.
PMID 8563753
 

Citation

This paper should be referenced as such :
Jean-Loup Huret
HOXA9 (homeobox A9)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):6-6.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/HOXA9ID61.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 33 ]
  t(7;11)(p15;p15) NUP98/HOXA9
t(7;17)(p15;q23) MSI2/HOXA9
t(3;7)(q21;p15) GATA2/HOXA9
t(5;7)(p13;p15) NIPBL/HOXA9
t(7;7)(p15;q34) TRB/HOXA9
t(7;8)(p15;q23) HOXA9/ANGPT1
t(7;17)(p15;q22) MSI2/HOXA9
t(X;7)(q13;p15) MED12/HOXA9
inv(11)(p15q23) NUP98/KMT2A
Pediatric T-Cell Acute Lymphoblastic Leukemia
r(8)
t(1;11)(q24;p15) NUP98/PRRX1
t(2;11)(p21;q23) KMT2A/?
t(4;11)(q21;q23) KMT2A/AFF1
t(4;11)(q21;p15) NUP98/RAP1GDS1
t(6;11)(q27;q23) KMT2A/AFDN
t(6;11)(q13;q23) KMT2A/SMAP1
t(7;11)(p15;p15) NUP98/HOXA9
t(7;14)(p15;q11) TRD/HOXA10
t(7;17)(p15;q23) MSI2/HOXA9
t(X;11)(q28;p15) NUP98/HMGB3
t(10;11)(q22;q23) KMT2A/TET1
t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM
t(11;16)(q23;p13.3) KMT2A/CREBBP
t(11;17)(q23;q21) KMT2A/ACACA
t(11;19)(q23;p13) KMT2A/MYO1F
T-lineage acute lymphoblastic leukemia (T-ALL)
t(3;7)(q21;p15) GATA2/HOXA9
t(5;7)(p13;p15) NIPBL/HOXA9
t(7;7)(p15;q34) TRB/HOXA9
t(7;8)(p15;q23) HOXA9/ANGPT1
t(7;17)(p15;q22) MSI2/HOXA9
t(X;7)(q13;p15) MED12/HOXA9


External links

Nomenclature
Cards
AtlasHOXA9ID61.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3205
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:38:55 CEST 2018

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