HOXA9 (homeobox A9)

1998-01-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
ABD-B,HOX1,HOX1.7,HOX1G
FUSION GENES

Proteins

Description

129 amino acids; DNA binding domain (homeobox) in C-term

Localisation

nuclear

Function

sequence specific transcription factor; role during embryonic development (patterning); HOX genes are also expressed in adult tissues, including blood cells; probable role in blood cell differenciation

Homology

with class 1 homeodomain proteins

Implicated in

Entity name
Disease
M2-M4 AML mostly; occasionally: CML-like cases
Prognosis
mean survival: 15 mths
Cytogenetics
sole anomaly most often
Hybrid gene
5 NUP98 - 3 HOXA9
Fusion protein
fuses the GLFG repeat domains of NUP98 to the HOXA9 homeobox

Breakpoints

Atlas Image

Bibliography

Pubmed IDLast YearTitleAuthors
85637541996The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.Borrow J et al
90587121997Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.Lawrence HJ et al
85637531996Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.Nakamura T et al

Other Information

Locus ID:

NCBI: 3205
MIM: 142956
HGNC: 5109
Ensembl: ENSG00000078399

Variants:

dbSNP: 3205
ClinVar: 3205
TCGA: ENSG00000078399
COSMIC: HOXA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078399ENST00000343483P31269
ENSG00000078399ENST00000396345A8MVF3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159609752005Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.276
147017352004Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.133
190566932009HOXA9 is required for survival in human MLL-rearranged acute leukemias.122
237166602013HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.108
240819452013A prognostic DNA methylation signature for stage I non-small-cell lung cancer.100
90587121997Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.96
129230562003Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.78
222514802012Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.75
223537102012miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.70
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Jean-Loup Huret

HOXA9 (homeobox A9)

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/gene/61/hoxa9